Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05588934 · ClinicalTrials.gov registry record · NA
Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)
A NA study of Sleep Deprivation and Caffeine, sponsored by University of Arizona.
- Recruiting
- Registry status
- NA
- Development phase
- 180
- Enrollment target
- 2
- Study locations
NCT05588934: Recruiting NA study of Sleep Deprivation and Caffeine, sponsored by University of Arizona.
NCT05588934 is a NA study of Sleep Deprivation and Caffeine that is actively recruiting participants, run by University of Arizona. The registered enrollment target is 180 participants, above the 86-participant average among 34 other Sleep Deprivation trials with a reported enrollment target (109% higher). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05588934, a NA study of Sleep Deprivation and Caffeine, is actively recruiting participants, sponsored by University of Arizona.
- RECRUITING
- Registry status
- NA
- Development phase
- 180 participants
- Enrollment target
- 2
- Study locations
Study Summary
This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side effects and subsequent sleep disruption. The questions this study aims to answer are: Whether the personalized caffeine recommendations improve vigilance, sleepiness, and cognition after total sleep deprivation, compared to standard recommendations; Whether the personalized caffeine recommendation better addresses the physical and emotional side effects of total sleep deprivation, compared to standard recommendations; And whether personalized caffeine recommendations aids in better recovery sleep after total sleep deprivation, compared to standard recommendations. Participants will be asked to: 1. Complete a 13-day at-home portion, wearing an actigraph watch to measure activity and sleep, and complete motor vigilance tests up to six times a day. 2. Complete a 4-day in-lab portion, where participants will have to complete one night of baseline sleep, undergo 62-hours of total sleep deprivation, and then complete one night of recovery sleep. 3. During the in-lab portion of the study, participants will be asked to complete more motor vigilance tests. Researchers will be comparing the personalized caffeine recommendation group against the standard caffeine recommendation to see if it is better at addressing each of the main questions.
Primary Outcome
The mean response time to psychomotor vigilance tests during the Peak Alertness Window.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Caffeine Gum
- OTHER Placebo Gum
Study Locations (2)
Arizona
- University of Arizona - Tucson
- University of Arizona Psychiatry Department - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2023-06-09 |
| Est. Completion | 2026-03 |
| Phase | NA |
What NCT05588934 shows while recruiting
NCT05588934 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, above the 86-participant average among 34 other Sleep Deprivation trials with a reported enrollment target (109% higher).
The record links to 2 conditions, with Sleep Deprivation appearing as the primary indexed condition, and to 2 interventions - of which Caffeine Gum is the first listed.
NCT05588934 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT05588934 about?
NCT05588934 is a clinical study titled "Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)". This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side effects and subsequent sleep disruption. The questions this study aims to ...
What is the current status of trial NCT05588934?
This trial is currently recruiting. It is a NA study. The enrollment target is 180 participants. The study started on 2023-06-09. Estimated completion is 2026-03.
What conditions does trial NCT05588934 study?
This clinical trial studies the following conditions: Sleep Deprivation, Caffeine.
What interventions are being tested in trial NCT05588934?
The interventions under investigation include: Caffeine Gum (DIETARY_SUPPLEMENT), Placebo Gum (OTHER).
Who is sponsoring clinical trial NCT05588934?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05588934 being conducted?
This trial has 2 study locations across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sleep Deprivation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05588934's enrollment target sits among peer trials
180 2nd of 34 higher than 32 of 34 other Sleep Deprivation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sleep Deprivation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Biomarkers of Increased Free Living Sleep Time
RECRUITING · NA
-
The Function of Biphasic Sleep in Infants
RECRUITING · NA
-
Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep
RECRUITING · NA
-
Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
RECRUITING · NA
-
Menstrual-phase-dependent Differences in Response to Sleep Loss
RECRUITING · NA
-
Acoustic Stimulation During Restricted Sleep After Sleep Deprivation
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01558804 · 180 participants
GRoup A StrePtococcus
- NCT02932176 · 180 participants
Machine Learning for Handheld Vascular Studies
- NCT03384563 · 180 participants · Phase 4
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
- NCT03423628 · 180 participants · Phase 1
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI