Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Severe Asthma: later-stage trial registry
6 of 10 indexed Severe Asthma trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · 6 currently recruiting · #1,724 of 28,707 conditions by registered trial count
Severe Asthma: 10 US clinical trials tracked, 6 recruiting.
Severe Asthma is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Generate Biomedicines, running 2 of these trials.
Enrollment posture brief
Registry condition severe-asthma
OPEN 6 | RECR 60% | LATE 4 | EARLY 2 | RANK #1724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Abuse, Drug (60% recruiting · 5 trials)
Severe Asthma lists 6 open slots (60% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Severe Asthma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Severe Asthma is recruiting above its size-band peers.
6 of 10 indexed trials (60%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Severe Asthma research.
Generate Biomedicines accounts for 2 of 10 trials (20%). 8 distinct sponsors appear on at least one study for this condition label.
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Typical Severe Asthma enrolment sits around 436 participants.
Median target enrolment is 436 among the 10 trials that report a genuine target (sentinel values excluded). 4 of those (40%) plan for fewer than 100 participants.
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Severe Asthma splits between interventional and observational designs.
6 interventional and 4 observational studies make up this index (60% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
10 total, page 1 of 1
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
Generate Biomedicines
NCT07359846
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
Generate Biomedicines
NCT07276724
A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)
Upstream Bio
NCT06966479
Phenotyping Asthma for Bronchial Thermoplasty
Massachusetts General Hospital
NCT03435237
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
Bastiaan Driehuys
NCT07139899
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
University of Kansas Medical Center
NCT06985225
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System
San Diego State University
NCT06389058
A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)
Upstream Bio
NCT06196879
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
AstraZeneca
NCT06473779
Treatment of Outpatients With Severe Asthma and Moderate or Severe Major Depressive Disorder
University of Texas Southwestern Medical Center
NCT00621946
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 3 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Severe Asthma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Severe Asthma trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Severe Asthma page
10 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 6 Severe Asthma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Generate Biomedicines sponsors the most Severe Asthma trials on record, review their full trial history before evaluating a specific study. See Generate Biomedicines's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Severe Asthma condition card totals 10 registered trials; most-linked intervention Placebo; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.