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ClinicalTrials.gov 6 recruiting now official registry

Severe Asthma clinical trials

6 of 10 indexed Severe Asthma trials are currently recruiting.

10 US clinical trials · 6 currently recruiting

Severe Asthma is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Generate Biomedicines, running 2 of these trials.

The research picture

Severe Asthma has 10 registered US clinical trials, 6 of them open to new participants right now, about 60% of the total.

6
recruiting participants now
60%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: Generate Biomedicines
Phase 22Phase 33Phase 41

Active & Recent Trials

10 total, page 1 of 1

RECRUITING Phase 3 786 participants

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)

Generate Biomedicines

NCT07359846

RECRUITING Phase 3 786 participants

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

Generate Biomedicines

NCT07276724

RECRUITING Phase 2 436 participants

A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

Upstream Bio

NCT06966479

RECRUITING 50 participants

Phenotyping Asthma for Bronchial Thermoplasty

Massachusetts General Hospital

NCT03435237

RECRUITING 5 participants

Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

Bastiaan Driehuys

NCT07139899

RECRUITING 5 participants

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma

University of Kansas Medical Center

NCT06985225

ACTIVE NOT RECRUITING 31,795 participants

Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System

San Diego State University

NCT06389058

ACTIVE NOT RECRUITING Phase 2 479 participants

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

Upstream Bio

NCT06196879

ACTIVE NOT RECRUITING Phase 3 326 participants

Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.

AstraZeneca

NCT06473779

COMPLETED Phase 4 26 participants

Treatment of Outpatients With Severe Asthma and Moderate or Severe Major Depressive Disorder

University of Texas Southwestern Medical Center

NCT00621946

Phase Distribution

PhaseTrial count
Phase 2 2
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Severe Asthma Trial Landscape

10 indexed Severe Asthma studies · 6 recruiting (60%).

Phase mix: 4 late (III/IV) vs 2 early (I/II).

Top sponsor: Generate Biomedicines (2 trials), 7 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Severe Asthma?

PlainTrial tracks 10 US clinical trials for Severe Asthma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Severe Asthma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.