Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
NCT06473779 · View on ClinicalTrials.gov ↗
Study Summary
The objective of this study is to assess the potential for tezepelumab-treated patients (subcutaneous administration) to reduce maintenance therapy without loss of asthma control in adolescent and adults with severe asthma.. Study details include: 1. The study duration will be up to 72 weeks. 2. The treatment duration will be up to 68 weeks. 3. The visit frequency will be once every 4 weeks (Q4W).
Conditions Studied
Interventions
- COMBINATION_PRODUCT Tezepelumab
- COMBINATION_PRODUCT Budesonide/formoterol
- COMBINATION_PRODUCT Albuterol/budesonide (AIRSUPRA®)
- COMBINATION_PRODUCT Mannitol
- COMBINATION_PRODUCT Salbutamol
Study Locations (20)
Other
- Research Site — Berazategui
- Research Site — CABA
- Research Site — Concepción del Uruguay
- Research Site — Mendoza
- Research Site — Mendoza
- Research Site — Quilmes
- Research Site — Rosario
- Research Site — Rosario
- Research Site — San Miguel de Tucumán
- Research Site — Santa Fe
- Research Site — Anderlecht
- Research Site — Edegem
California
- Research Site — Palmdale
Colorado
- Research Site — Colorado Springs
Florida
- Research Site — Miami
Massachusetts
- Research Site — Boston
Missouri
- Research Site — St Louis
New Jersey
- Research Site — New Brunswick
Oklahoma
- Research Site — Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 326 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2027-06-25 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06473779
The ClinicalTrials.gov registry entry for NCT06473779 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 326 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Severe Asthma appearing as the primary indexed condition, and to 5 interventions — of which Tezepelumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06473779 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06473779 about?
NCT06473779 is a clinical study titled "Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.". The objective of this study is to assess the potential for tezepelumab-treated patients (subcutaneous administration) to reduce maintenance therapy without loss of asthma control in adolescent and adults with severe asthma.. Study details include: 1. The study duration will be up to 72 weeks. 2. T...
What is the current status of trial NCT06473779?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 326 participants. The study started on 2024-09-30. Estimated completion is 2027-06-25.
What conditions does trial NCT06473779 study?
This clinical trial studies the following conditions: Severe Asthma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06473779?
The interventions under investigation include: Tezepelumab (COMBINATION_PRODUCT), Budesonide/formoterol (COMBINATION_PRODUCT), Albuterol/budesonide (AIRSUPRA®) (COMBINATION_PRODUCT), Mannitol (COMBINATION_PRODUCT), Salbutamol (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06473779?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06473779 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Massachusetts, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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