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NCT06985225 · ClinicalTrials.gov registry record
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
A clinical trial of Severe Asthma, sponsored by University of Kansas Medical Center.
- Recruiting
- Registry status
- 5
- Enrollment target
- 1
- Study location
NCT06985225: Recruiting study of Severe Asthma, sponsored by University of Kansas Medical Center.
NCT06985225 is a study of Severe Asthma that is actively recruiting participants, run by University of Kansas Medical Center. The registered enrollment target is 5 participants, below the 3,854-participant average among 9 other Severe Asthma trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06985225, a study of Severe Asthma, is actively recruiting participants, sponsored by University of Kansas Medical Center.
- RECRUITING
- Registry status
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Primary Outcome
The primary endpoint of this study is the ventilation defect percent (VDP; measured by Xe-MRI) in regions of the lungs that are downstream of mucus plugs (identified on CT imaging).
Conditions Studied
Interventions
- COMBINATION_PRODUCT Hyperpolarized 129 Xenon
Study Locations (1)
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2025-06 |
| Est. Completion | 2026-12 |
What NCT06985225 shows while recruiting
NCT06985225 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 3,854-participant average among 9 other Severe Asthma trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Severe Asthma appearing as the primary indexed condition, and to 1 intervention - of which Hyperpolarized 129 Xenon is the first listed.
NCT06985225 reports a single indexed study location in Kansas.
Frequently Asked Questions
What is clinical trial NCT06985225 about?
NCT06985225 is a clinical study titled "Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma". In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corr...
What is the current status of trial NCT06985225?
This trial is currently recruiting. The enrollment target is 5 participants. The study started on 2025-06. Estimated completion is 2026-12.
What conditions does trial NCT06985225 study?
This clinical trial studies the following conditions: Severe Asthma.
What interventions are being tested in trial NCT06985225?
The interventions under investigation include: Hyperpolarized 129 Xenon (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06985225?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06985225 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Severe Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06985225's enrollment target sits among peer trials
5 9th of 9 the lowest of 9 other Severe Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Severe Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
RECRUITING
-
A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)
RECRUITING · Phase 2
-
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
RECRUITING · Phase 3
-
Phenotyping Asthma for Bronchial Thermoplasty
RECRUITING
-
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
RECRUITING · Phase 3
-
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
ACTIVE NOT RECRUITING · Phase 3
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