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NCT07139899 · ClinicalTrials.gov registry record
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
A clinical trial of Severe Asthma, sponsored by Bastiaan Driehuys.
- Recruiting
- Registry status
- 5
- Enrollment target
- 1
- Study location
NCT07139899: Recruiting study of Severe Asthma, sponsored by Bastiaan Driehuys.
NCT07139899 is a study of Severe Asthma that is actively recruiting participants, run by Bastiaan Driehuys. The registered enrollment target is 5 participants, below the 3,854-participant average among 9 other Severe Asthma trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07139899, a study of Severe Asthma, is actively recruiting participants, sponsored by Bastiaan Driehuys.
- RECRUITING
- Registry status
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Primary Outcome
The primary endpoint of this study is the ventilation defect percent (VDP; measured by Xe-MRI) in regions of the lungs that are downstream of mucus plugs (identified on CT imaging).
Conditions Studied
Interventions
- COMBINATION_PRODUCT Hyperpolarized Xenon 129
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2025-11-17 |
| Est. Completion | 2027-09 |
What NCT07139899 shows while recruiting
NCT07139899 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 3,854-participant average among 9 other Severe Asthma trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Severe Asthma appearing as the primary indexed condition, and to 1 intervention - of which Hyperpolarized Xenon 129 is the first listed.
NCT07139899 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07139899 about?
NCT07139899 is a clinical study titled "Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma". In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corr...
What is the current status of trial NCT07139899?
This trial is currently recruiting. The enrollment target is 5 participants. The study started on 2025-11-17. Estimated completion is 2027-09.
What conditions does trial NCT07139899 study?
This clinical trial studies the following conditions: Severe Asthma.
What interventions are being tested in trial NCT07139899?
The interventions under investigation include: Hyperpolarized Xenon 129 (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT07139899?
This trial is sponsored by Bastiaan Driehuys, which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07139899 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Severe Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07139899's enrollment target sits among peer trials
5 9th of 9 the lowest of 9 other Severe Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Severe Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)
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Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma
RECRUITING
-
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
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-
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
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