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Retinopathy of Prematurity clinical trials
Every US clinical trial registered for Retinopathy of Prematurity — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
10 US clinical trials · 3 currently recruiting
The research picture
Retinopathy of Prematurity has 10 registered US clinical trials, 3 of them open to new participants right now — about 30% of the total.
- 3
- recruiting participants now
- 30%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: National Eye Institute (NEI)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Clinical and Genetic Analysis of ROP
Oregon Health and Science University
NCT04420156
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Duke University
NCT04995341
Imaging Retinal Vasculature in Infant Eyes
Duke University
NCT05558059
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
Regeneron Pharmaceuticals
NCT04515524
Bevacizumab Treatment For Type 1 ROP
Jaeb Center for Health Research
NCT04634578
Validation of i-ROP DL to Detect More Than Mild ROP
Siloam Vision
NCT06109285
Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants
University of Virginia
NCT00845624
Skin and Serum Carotenoids in Preterm Infants Fed on a Formula Supplemented With Carotenoids
University of Utah
NCT00872664
The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)
National Eye Institute (NEI)
NCT00000156
Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity
National Eye Institute (NEI)
NCT00000133
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Retinopathy of Prematurity Trial Landscape
ClinicalTrials.gov lists 10 US studies indexed under Retinopathy of Prematurity, and 3 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Retinopathy of Prematurity shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Retinopathy of Prematurity is led by National Eye Institute (NEI) with 2 indexed trials, alongside 7 other organizations in the top contributor list. The list on this page surfaces up to 10 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Retinopathy of Prematurity?
PlainTrial tracks 10 US clinical trials for Retinopathy of Prematurity, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Retinopathy of Prematurity?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.