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ClinicalTrials.gov 7 recruiting now official registry

Refractory Neuroblastoma clinical trials

7 of 10 indexed Refractory Neuroblastoma trials are currently recruiting.

10 US clinical trials · 7 currently recruiting

Refractory Neuroblastoma is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Stephan Grupp MD PhD, running 2 of these trials.

The research picture

Refractory Neuroblastoma has 10 registered US clinical trials, 7 of them open to new participants right now, about 70% of the total.

7
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Stephan Grupp MD PhD
Phase 19Phase 21

Active & Recent Trials

10 total, page 1 of 1

RECRUITING Phase 1 59 participants

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

Theodore Laetsch

NCT06721689

RECRUITING Phase 1 45 participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Stephan Grupp MD PhD

NCT05650749

RECRUITING Phase 1 42 participants

Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma

Roberto Chiarle

NCT06803875

RECRUITING Phase 1 38 participants

PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

Stephan Grupp MD PhD

NCT07007117

RECRUITING Phase 1 31 participants

NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab

Nationwide Children's Hospital

NCT04211675

RECRUITING Phase 1 24 participants

Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma

Emory University

NCT05400603

RECRUITING Phase 1 18 participants

Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

Steven DuBois, MD

NCT07027748

ACTIVE NOT RECRUITING Phase 2 94 participants

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Children's Oncology Group

NCT03794349

ACTIVE NOT RECRUITING Phase 1 94 participants

C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N)

Baylor College of Medicine

NCT03635632

ACTIVE NOT RECRUITING Phase 1 27 participants

Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma

National Cancer Institute (NCI)

NCT01711554

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Neuroblastoma Trial Landscape

10 indexed Refractory Neuroblastoma studies · 7 recruiting (70%).

Phase mix: 0 late (III/IV) vs 10 early (I/II).

Top sponsor: Stephan Grupp MD PhD (2 trials), 8 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Neuroblastoma?

PlainTrial tracks 10 US clinical trials for Refractory Neuroblastoma, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Neuroblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.