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ClinicalTrials.gov 10 recruiting now official registry

Refractory Cancer clinical trials

10 of 16 indexed Refractory Cancer trials are currently recruiting.

16 US clinical trials · 10 currently recruiting

Refractory Cancer is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Immatics US, running 2 of these trials.

The research picture

Refractory Cancer has 16 registered US clinical trials, 10 of them open to new participants right now, about 63% of the total.

10
recruiting participants now
63%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Immatics US
Phase 110Phase 24

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 1 375 participants

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

Immatics US

NCT03686124

RECRUITING Phase 1 365 participants

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

GV20 Therapeutics

NCT05669430

RECRUITING Phase 1 130 participants

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Sairopa B.V.

NCT05856981

RECRUITING Phase 1 80 participants

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

BeOne Medicines

NCT06634589

RECRUITING Phase 2 50 participants

Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

Wake Forest University Health Sciences

NCT04337580

RECRUITING Phase 1 37 participants

Pembrolizumab, Ibrutinib and Rituximab in PCNSL

Dana-Farber Cancer Institute

NCT04421560

RECRUITING Phase 1 33 participants

Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

UNC Lineberger Comprehensive Cancer Center

NCT06096038

RECRUITING Phase 2 32 participants

Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

Dipenkumar Modi

NCT05852717

RECRUITING Phase 1 23 participants

A Study of Avutometinib for People With Solid Tumor Cancers

Memorial Sloan Kettering Cancer Center

NCT06104488

RECRUITING Phase 2 15 participants

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

Baptist Health South Florida

NCT05681195

ACTIVE NOT RECRUITING Phase 2 350 participants

9-ING-41 in Patients with Advanced Cancers

Actuate Therapeutics

NCT03678883

ACTIVE NOT RECRUITING Phase 1 77 participants

A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody

HotSpot Therapeutics

NCT05662397

ACTIVE NOT RECRUITING NA 36 participants

Individualized Treatments in Adults With Relapsed/Refractory Cancers

Case Comprehensive Cancer Center

NCT06024603

COMPLETED 242 participants

Human Leukocyte Antigen Typing and Tumor Antigen Expression Profiling

Immatics US

NCT03760952

COMPLETED Early Phase 1 86 participants

Molecular Profiling Protocol (SCRI-CA-001)

Scottsdale Healthcare

NCT00530192

COMPLETED Phase 1 23 participants

A Study of the Safety and PK of PCS6422 (Eniluracil) with Capecitabine in Patients with Advanced, Refractory GI Tract Tumors

Processa Pharmaceuticals

NCT04861987

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Cancer Trial Landscape

16 indexed Refractory Cancer studies · 10 recruiting (63%).

Phase mix: 0 late (III/IV) vs 14 early (I/II).

Top sponsor: Immatics US (2 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Cancer?

PlainTrial tracks 16 US clinical trials for Refractory Cancer, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.