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Presbyopia clinical trials
Every US clinical trial registered for Presbyopia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
39 US clinical trials · 9 currently recruiting
The research picture
Presbyopia has 39 registered US clinical trials, 9 of them open to new participants right now — about 23% of the total.
- 9
- recruiting participants now
- 23%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Alcon Research
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Clinical Applications of Advanced Ophthalmic Imaging
University of Miami
NCT03135327
IC-8 Apthera IOL New Enrollment Post Approval Study
Bausch & Lomb Incorporated
NCT06060041
North American Comfilcon A Clinical Study
CooperVision International Limited (CVIL)
NCT06902584
Post Market Clinical Evaluation of Clareon PanOptix Pro and Clareon PanOptix Pro Toric IOLs
Alcon Research
NCT07161635
Phase III Presbyopia Correction Using the VIS Opti-K™ System
VIS
NCT06487897
A Clinical Comparison of Proclear® 1 Day Multifocal and Clariti® 1 Day Multifocal 3 Add
CooperVision International Limited (CVIL)
NCT06869044
Comfort and Vision With TOTAL30 Multifocal Lenses
Scripps Poway Eyecare and Optometry
NCT07284966
Quality of Life in Presbyopic Patients Who Are Treated With Qlosi
Southern College of Optometry
NCT07113210
Presbyopic Wear Experience With Multifocal Lenses Compared to Single Vision Lenses and Reading Glasses
Ohio State University
NCT07218731
Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix
Alcon Research
NCT05796453
Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement
Alanna Nattis, DO
NCT04570579
Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia
Visus Therapeutics
NCT05135286
Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens
AcuFocus
NCT03633695
Phase 3 Safety Study for the Treatment of Presbyopia Subjects
LENZ Therapeutics
NCT05753189
Safety and Effectiveness Study of the AcuFocus Corneal Inlay ACI 7000PDT in Presbyopes
AcuFocus
NCT00819299
An Evaluation of the Efficacy and Safety of CSF-1 in the Temporary Correction of Presbyopia (NEAR-2)
Orasis Pharmaceuticals
NCT04599972
Handling Comparison Between Two Contact Lens Types
Johnson & Johnson Vision Care
NCT02310126
Assessing Fitting Guides in Alcon Multifocal Contact Lenses
Alcon Research
NCT03118934
Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults
Eyenovia
NCT05114486
A Study of Safety and Efficacy of UNR844 Chloride (UNR844-Cl) Eye Drops in Subjects With Presbyopia.
Novartis Pharmaceuticals
NCT03809611
Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses
Alcon Research
NCT05338333
Clinical Assessment of a Customized Free-form Progressive Addition Lens Spectacle
University of California, Berkeley
NCT01234207
Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults
Eyenovia
NCT04657172
Assessment of Three Basic Progressive Lens Designs
Western University of Health Sciences
NCT05252871
Monofocal IOL Visual Outcomes When Targeting Mini Monovision
Carolina Eyecare Physicians
NCT05069415
Pilot Dispensing Study of Two Marketed Daily Disposable Multifocal Contact Lenses
Johnson & Johnson Vision Care
NCT07076160
Clareon PanOptix Pro vs. Clareon PanOptix - Study B
Alcon Research
NCT06401551
Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia
LENZ Therapeutics
NCT05294328
Comparing the Performance of 1 Day Multifocal Contact Lenses
CooperVision
NCT04449263
Synergy Lens Outcomes Evaluation
Center For Sight
NCT05418153
Apioc Contact Lens Feasibility
Lentechs
NCT03688672
Clinical Evaluation of a Multifocal Contact Lens on Symptomatic Patients
Johnson & Johnson Vision Care
NCT01016652
Analysis of Defocus Curve of Pre-Presbyopic and Emerging Presbyopic Patients
Vance Thompson Vision
NCT04474782
Evaluation of Soft Multifocal Lenses in Presbyopic Previous Contact Lens Wearers
Jennifer Fogt
NCT06053463
Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia
LENZ Therapeutics
NCT02554396
Clinical Validation Study of Comfilcon A Multifocal Toric Contact Lenses
CooperVision
NCT03417557
Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses
Alcon Research
NCT05886907
A Dispensing Clinical Trial of Comfilcon A Extended Range Multifocal Lenses
CooperVision
NCT02719353
A Dispensing Clinical Trial of Comfilcon A Extended Range Multifocal Lenses
CooperVision
NCT02719366
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 3 |
| Phase 3 | 6 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Presbyopia Trial Landscape
ClinicalTrials.gov lists 39 US studies indexed under Presbyopia, and 9 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Presbyopia shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Presbyopia is led by Alcon Research with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 39 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Presbyopia?
PlainTrial tracks 39 US clinical trials for Presbyopia, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Presbyopia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.