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ClinicalTrials.gov 39 recruiting now official registry

Posttraumatic Stress Disorder clinical trials

39 of 119 indexed Posttraumatic Stress Disorder trials are currently recruiting.

119 US clinical trials · 39 currently recruiting

Posttraumatic Stress Disorder is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 26 of these trials.

The research picture

Posttraumatic Stress Disorder has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.

39
recruiting participants now
33%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
26
top sponsor: VA Office of Research and Development
Phase 17Phase 29Phase 33Phase 46

Active & Recent Trials

119 total, page 1 of 3

RECRUITING NA 350 participants

Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury

Medical University of South Carolina

NCT05497115

RECRUITING NA 306 participants

Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

Baylor College of Medicine

NCT05843695

RECRUITING NA 302 participants

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

The University of Texas Health Science Center at San Antonio

NCT07176273

RECRUITING NA 300 participants

Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes

Michigan State University

NCT05564663

RECRUITING NA 300 participants

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

Baylor Research Institute

NCT06210711

RECRUITING NA 300 participants

Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors

Medical University of South Carolina

NCT05086757

RECRUITING NA 216 participants

Investigating Cardiac Health of Adults With Trauma

Nova Southeastern University

NCT05700201

RECRUITING NA 200 participants

Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder

VA Office of Research and Development

NCT05780177

RECRUITING NA 200 participants

Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

VA Office of Research and Development

NCT05267665

RECRUITING Phase 2 200 participants

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Texas A&M University

NCT05959434

RECRUITING NA 180 participants

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

University of Texas at Austin

NCT05427708

RECRUITING Phase 2 175 participants

Ketamine, SGB and Combination Treatment for TBI

Northwestern University

NCT06608277

RECRUITING NA 170 participants

Written Exposure Therapy for Veterans With SUD and PTSD

VA Office of Research and Development

NCT05327504

RECRUITING NA 167 participants

Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

University of California, Los Angeles

NCT05516277

RECRUITING Phase 2 162 participants

Enhancing Week-long Psychological Treatment for PTSD With Ketamine

Yale University

NCT05737693

RECRUITING NA 150 participants

Mobile Anger Reduction Intervention

VA Office of Research and Development

NCT06094933

RECRUITING NA 140 participants

Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

Medical University of South Carolina

NCT05786157

RECRUITING NA 135 participants

Positive Processes and Transition to Health (PATH)

Case Western Reserve University

NCT06093906

RECRUITING NA 135 participants

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

University of Vermont

NCT06288711

RECRUITING NA 124 participants

Evaluation of the PE Coach Mobile Application Among Veterans With PTSD

VA Office of Research and Development

NCT04959695

RECRUITING NA 120 participants

A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

University of Pennsylvania

NCT06234969

RECRUITING NA 120 participants

Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples

Penn State University

NCT06047691

RECRUITING NA 120 participants

Effects of Games on Memory Reconsolidation and Trauma Symptoms

University of Texas at Austin

NCT06129435

RECRUITING NA 108 participants

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

Boston University Charles River Campus

NCT05624931

RECRUITING Phase 1 68 participants

Mitigating PTSD-CUD After Sexual Assault

University of Nevada, Las Vegas

NCT05989841

RECRUITING NA 64 participants

Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

University of New Mexi

NCT06449326

RECRUITING NA 60 participants

Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

Clemson University

NCT06608979

RECRUITING NA 60 participants

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

University of Washington

NCT06219408

RECRUITING Phase 2 60 participants

Dose Optimization of MDMA-Assisted Therapy for PTSD

Bronx VA Medical Center

NCT06418178

RECRUITING NA 60 participants

Resilient Roots: Supporting Youth and Families

University of Rochester

NCT06535516

RECRUITING NA 60 participants

Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry

University of California, Los Angeles

NCT04529031

RECRUITING NA 50 participants

Mechanisms Underlying the Efficacy of Prolonged Exposure

VA Boston Healthcare System

NCT05663151

RECRUITING NA 50 participants

Biomarkers in the Retina for Prognosticating Mental Health Treatments

VA Puget Sound Health Care System

NCT06363968

RECRUITING NA 40 participants

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

VA Office of Research and Development

NCT04871100

RECRUITING Phase 1 40 participants

Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University

NCT06989957

RECRUITING NA 40 participants

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Walter Reed National Military Medical Center

NCT05414708

RECRUITING Phase 3 32 participants

Repurposing Low-Dose Clonidine for PTSD in Veterans

Wake Forest University Health Sciences

NCT04877093

RECRUITING NA 30 participants

Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

Massachusetts General Hospital

NCT06429293

RECRUITING Early Phase 1 20 participants

Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers

Weill Medical College of Cornell University

NCT04887116

ACTIVE NOT RECRUITING 663 participants

Stress, Adjustment And Growth In Children With Cancer And Their Parents

St. Jude Children's Research Hospital

NCT01044160

ACTIVE NOT RECRUITING NA 360 participants

Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD

Stanford University

NCT05037175

ACTIVE NOT RECRUITING NA 333 participants

CBT vs. Supportive Texts for PTSD & Hazardous Drinking (Project Better Study 2)

University of Washington

NCT06648395

ACTIVE NOT RECRUITING Phase 4 302 participants

A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD

University of Pennsylvania

NCT04961190

ACTIVE NOT RECRUITING NA 179 participants

A Case Formulation Approach to Cognitive Processing Therapy

VA Office of Research and Development

NCT04407767

ACTIVE NOT RECRUITING NA 144 participants

Multisite Feasibility of Compassion Meditation for Veterans With Posttraumatic Stress Disorder (PTSD)

Veterans Medical Research Foundation

NCT04793698

ACTIVE NOT RECRUITING Phase 3 87 participants

Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests

VA Office of Research and Development

NCT03539614

ACTIVE NOT RECRUITING NA 82 participants

Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault

University of Washington

NCT04124380

ACTIVE NOT RECRUITING NA 76 participants

Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations

NYU Langone Health

NCT06307340

ACTIVE NOT RECRUITING 33 participants

Using Data Science To Center Patient Perspectives in Mechanism Discovery

Cambridge Health Alliance

NCT06233968

ACTIVE NOT RECRUITING NA 20 participants

tAN for PTSD and OUD in Buprenorphine Therapy

University of Cincinnati

NCT06130501

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 9
Phase 3 3
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Posttraumatic Stress Disorder Trial Landscape

119 indexed Posttraumatic Stress Disorder studies · 39 recruiting (33%).

Phase mix: 9 late (III/IV) vs 16 early (I/II).

Top sponsor: VA Office of Research and Development (26 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Posttraumatic Stress Disorder?

PlainTrial tracks 119 US clinical trials for Posttraumatic Stress Disorder, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Posttraumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.