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Posttraumatic Stress Disorder clinical trials
39 of 119 indexed Posttraumatic Stress Disorder trials are currently recruiting.
119 US clinical trials · 39 currently recruiting
Posttraumatic Stress Disorder is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 26 of these trials.
The research picture
Posttraumatic Stress Disorder has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.
- 39
- recruiting participants now
- 33%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 26
- top sponsor: VA Office of Research and Development
Active & Recent Trials
119 total, page 1 of 3
Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
Medical University of South Carolina
NCT05497115
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
Baylor College of Medicine
NCT05843695
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
The University of Texas Health Science Center at San Antonio
NCT07176273
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
Michigan State University
NCT05564663
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
Baylor Research Institute
NCT06210711
Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
Medical University of South Carolina
NCT05086757
Investigating Cardiac Health of Adults With Trauma
Nova Southeastern University
NCT05700201
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT05780177
Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement
VA Office of Research and Development
NCT05267665
Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD
Texas A&M University
NCT05959434
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
University of Texas at Austin
NCT05427708
Ketamine, SGB and Combination Treatment for TBI
Northwestern University
NCT06608277
Written Exposure Therapy for Veterans With SUD and PTSD
VA Office of Research and Development
NCT05327504
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
University of California, Los Angeles
NCT05516277
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Yale University
NCT05737693
Mobile Anger Reduction Intervention
VA Office of Research and Development
NCT06094933
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Medical University of South Carolina
NCT05786157
Positive Processes and Transition to Health (PATH)
Case Western Reserve University
NCT06093906
Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD
University of Vermont
NCT06288711
Evaluation of the PE Coach Mobile Application Among Veterans With PTSD
VA Office of Research and Development
NCT04959695
A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
University of Pennsylvania
NCT06234969
Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples
Penn State University
NCT06047691
Effects of Games on Memory Reconsolidation and Trauma Symptoms
University of Texas at Austin
NCT06129435
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Boston University Charles River Campus
NCT05624931
Mitigating PTSD-CUD After Sexual Assault
University of Nevada, Las Vegas
NCT05989841
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
University of New Mexi
NCT06449326
Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders
Clemson University
NCT06608979
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
University of Washington
NCT06219408
Dose Optimization of MDMA-Assisted Therapy for PTSD
Bronx VA Medical Center
NCT06418178
Resilient Roots: Supporting Youth and Families
University of Rochester
NCT06535516
Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry
University of California, Los Angeles
NCT04529031
Mechanisms Underlying the Efficacy of Prolonged Exposure
VA Boston Healthcare System
NCT05663151
Biomarkers in the Retina for Prognosticating Mental Health Treatments
VA Puget Sound Health Care System
NCT06363968
Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use
VA Office of Research and Development
NCT04871100
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Johns Hopkins University
NCT06989957
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Walter Reed National Military Medical Center
NCT05414708
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences
NCT04877093
Impact of Cognitive Behavioral Therapy on PTSD-CVD Link
Massachusetts General Hospital
NCT06429293
Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers
Weill Medical College of Cornell University
NCT04887116
Stress, Adjustment And Growth In Children With Cancer And Their Parents
St. Jude Children's Research Hospital
NCT01044160
Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD
Stanford University
NCT05037175
CBT vs. Supportive Texts for PTSD & Hazardous Drinking (Project Better Study 2)
University of Washington
NCT06648395
A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD
University of Pennsylvania
NCT04961190
A Case Formulation Approach to Cognitive Processing Therapy
VA Office of Research and Development
NCT04407767
Multisite Feasibility of Compassion Meditation for Veterans With Posttraumatic Stress Disorder (PTSD)
Veterans Medical Research Foundation
NCT04793698
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
VA Office of Research and Development
NCT03539614
Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault
University of Washington
NCT04124380
Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations
NYU Langone Health
NCT06307340
Using Data Science To Center Patient Perspectives in Mechanism Discovery
Cambridge Health Alliance
NCT06233968
tAN for PTSD and OUD in Buprenorphine Therapy
University of Cincinnati
NCT06130501
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 9 |
| Phase 3 | 3 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Posttraumatic Stress Disorder Trial Landscape
119 indexed Posttraumatic Stress Disorder studies · 39 recruiting (33%).
Phase mix: 9 late (III/IV) vs 16 early (I/II).
Top sponsor: VA Office of Research and Development (26 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Posttraumatic Stress Disorder?
PlainTrial tracks 119 US clinical trials for Posttraumatic Stress Disorder, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Posttraumatic Stress Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.