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ClinicalTrials.gov 39 recruiting now official registry

Posttraumatic Stress Disorder clinical trials

39 of 119 indexed Posttraumatic Stress Disorder trials are currently recruiting.

119 US clinical trials · 39 currently recruiting

Posttraumatic Stress Disorder is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 26 of these trials.

The research picture

Posttraumatic Stress Disorder has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.

39
recruiting participants now
33%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
26
top sponsor: VA Office of Research and Development
Phase 17Phase 29Phase 33Phase 46

Active & Recent Trials

119 total, page 2 of 3

ACTIVE NOT RECRUITING NA 8 participants

LED Treatment to Improve Cognition and Promote Recovery in TBI

VA Office of Research and Development

NCT02404402

COMPLETED Phase 1 442 participants

Acute Intervention to Reduce Distress Following Sexual Assault

Medical University of South Carolina

NCT01622855

COMPLETED NA 294 participants

Comparing Group Therapies for Veterans With Depression and PTSD

VA Office of Research and Development

NCT03979040

COMPLETED NA 241 participants

Neural Markers and Rehabilitation of Executive Functioning in Veterans With Traumatic Brain Injury and Posttraumatic Stress Disorder

University of North Carolina, Chapel Hill

NCT01410721

COMPLETED 230 participants

An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans

VA Eastern Colorado Health Care System

NCT01502436

COMPLETED NA 192 participants

Written Exposure Therapy for Posttraumatic Stress Disorder

Boston University

NCT01800773

COMPLETED NA 187 participants

A Comparison of CPT Versus ART Versus WL

University of Cincinnati

NCT03384706

COMPLETED NA 184 participants

Loving-Kindness Meditation for PTSD

VA Office of Research and Development

NCT01962714

COMPLETED NA 175 participants

In-Home Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD)

Veterans Medical Research Foundation

NCT03110302

COMPLETED NA 163 participants

Efficacy Trial of Stress Check-Up

University of Washington

NCT03423394

COMPLETED NA 160 participants

The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD

University of Pennsylvania

NCT02720497

COMPLETED NA 158 participants

Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Wave Neuroscience

NCT02990793

COMPLETED NA 129 participants

Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD

VA Office of Research and Development

NCT01090180

COMPLETED Phase 2 118 participants

An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)

University of California, Los Angeles

NCT01641146

COMPLETED Phase 2 108 participants

Women Overcoming and Managing Adversity Now (WOMAN) Study

UConn Health

NCT01324765

COMPLETED 105 participants

Brain Function in Mentally Ill Adolescents

National Institute of Mental Health (NIMH)

NCT00025857

COMPLETED NA 105 participants

Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders

VA Office of Research and Development

NCT01947647

COMPLETED NA 100 participants

Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD

United States Naval Medical Center, San Diego

NCT02874131

COMPLETED Phase 3 100 participants

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)

Lykos Therapeutics

NCT03537014

COMPLETED NA 95 participants

Optimal Dose of Early Intervention to Prevent PTSD

Emory University

NCT01959620

COMPLETED NA 87 participants

Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury

VA Office of Research and Development

NCT03906240

COMPLETED NA 86 participants

A Mobile Health Solution for Homework During CBT

University of South Florida

NCT04931199

COMPLETED NA 82 participants

Enhancement of PTSD Treatment With Computerized Executive Function Training

VA Office of Research and Development

NCT03260127

COMPLETED NA 81 participants

Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans

VA Office of Research and Development

NCT00805532

COMPLETED NA 81 participants

Cognitive Training for PTSD

VA Office of Research and Development

NCT03316196

COMPLETED NA 81 participants

Remote Study of NightWare for PTSD With Nightmares

NightWare

NCT03934658

COMPLETED Phase 2 80 participants

Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD

Multidisciplinary Association for Psychedelic Studies

NCT02759185

COMPLETED NA 76 participants

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

VA Office of Research and Development

NCT02641496

COMPLETED NA 73 participants

Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD

VA Office of Research and Development

NCT02391402

COMPLETED NA 73 participants

Improving Sleep to Reduce Risk for Substance Use Disorder

Florida State University

NCT03226132

COMPLETED NA 71 participants

Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)

VA Office of Research and Development

NCT00701064

COMPLETED NA 70 participants

Writing Wrongs: Expressive Writing for Microaggressions

Auburn University

NCT06276725

COMPLETED NA 65 participants

Online Coping Skills Counseling for Problem Gambling and Trauma

University of Windsor

NCT03145792

COMPLETED Phase 1 63 participants

Stepped Care for Young Children After Trauma

University of South Florida

NCT01603563

COMPLETED NA 60 participants

Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial

Rush University Medical Center

NCT05534126

COMPLETED NA 57 participants

Brief Restructuring Intervention Following Trauma Exposure

University of Washington

NCT02808468

COMPLETED NA 55 participants

Mindfulness-Based Stress Reduction and the Microbiome

Seattle Institute for Biomedical and Clinical Research

NCT01619384

COMPLETED NA 54 participants

Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)

VA Office of Research and Development

NCT02248675

COMPLETED NA 54 participants

Using mHealth to Improve Emotional Recovery After Pediatric Injury

Medical University of South Carolina

NCT04579198

COMPLETED NA 52 participants

EEG Biofeedback in the Treatment of Chronic Treatment-Resistant PTSD

Justice Resource Institute

NCT01259921

COMPLETED NA 50 participants

Written Exposure in Substance Treatment

Potomac Health Foundations

NCT06296940

COMPLETED NA 49 participants

An Efficient Treatment for Posttraumatic Injury for Firefighters

Palo Alto Veterans Institute for Research

NCT05950035

COMPLETED NA 40 participants

rTMS for PTSD Comorbid With Major Depressive Disorder

Butler Hospital

NCT02273063

COMPLETED NA 40 participants

NightWare and Cardiovascular Health in Adults With PTSD

University of Colorado, Denver

NCT05365607

COMPLETED 39 participants

Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-traumatic Stress Disorder

Cedars-Sinai Medical Center

NCT00815204

COMPLETED Phase 4 38 participants

Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial

Research Foundation for Mental Hygiene

NCT01178671

COMPLETED Phase 1 36 participants

Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence

VA Office of Research and Development

NCT02576899

COMPLETED NA 34 participants

An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military

University of Pennsylvania

NCT03337750

COMPLETED Phase 2 33 participants

IOK Treatment Study

VA Office of Research and Development

NCT01605799

COMPLETED NA 31 participants

A Pilot Exercise Study for PTSD in Women Veterans

North Texas Veterans Healthcare System

NCT01892033

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 9
Phase 3 3
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Posttraumatic Stress Disorder Trial Landscape

119 indexed Posttraumatic Stress Disorder studies · 39 recruiting (33%).

Phase mix: 9 late (III/IV) vs 16 early (I/II).

Top sponsor: VA Office of Research and Development (26 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Posttraumatic Stress Disorder?

PlainTrial tracks 119 US clinical trials for Posttraumatic Stress Disorder, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Posttraumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.