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Posttraumatic Stress Disorder clinical trials
39 of 119 indexed Posttraumatic Stress Disorder trials are currently recruiting.
119 US clinical trials · 39 currently recruiting
Posttraumatic Stress Disorder is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 26 of these trials.
The research picture
Posttraumatic Stress Disorder has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.
- 39
- recruiting participants now
- 33%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 26
- top sponsor: VA Office of Research and Development
Active & Recent Trials
119 total, page 2 of 3
LED Treatment to Improve Cognition and Promote Recovery in TBI
VA Office of Research and Development
NCT02404402
Acute Intervention to Reduce Distress Following Sexual Assault
Medical University of South Carolina
NCT01622855
Comparing Group Therapies for Veterans With Depression and PTSD
VA Office of Research and Development
NCT03979040
Neural Markers and Rehabilitation of Executive Functioning in Veterans With Traumatic Brain Injury and Posttraumatic Stress Disorder
University of North Carolina, Chapel Hill
NCT01410721
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans
VA Eastern Colorado Health Care System
NCT01502436
Written Exposure Therapy for Posttraumatic Stress Disorder
Boston University
NCT01800773
A Comparison of CPT Versus ART Versus WL
University of Cincinnati
NCT03384706
Loving-Kindness Meditation for PTSD
VA Office of Research and Development
NCT01962714
In-Home Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD)
Veterans Medical Research Foundation
NCT03110302
Efficacy Trial of Stress Check-Up
University of Washington
NCT03423394
The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD
University of Pennsylvania
NCT02720497
Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
Wave Neuroscience
NCT02990793
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
VA Office of Research and Development
NCT01090180
An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)
University of California, Los Angeles
NCT01641146
Women Overcoming and Managing Adversity Now (WOMAN) Study
UConn Health
NCT01324765
Brain Function in Mentally Ill Adolescents
National Institute of Mental Health (NIMH)
NCT00025857
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
VA Office of Research and Development
NCT01947647
Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD
United States Naval Medical Center, San Diego
NCT02874131
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)
Lykos Therapeutics
NCT03537014
Optimal Dose of Early Intervention to Prevent PTSD
Emory University
NCT01959620
Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury
VA Office of Research and Development
NCT03906240
A Mobile Health Solution for Homework During CBT
University of South Florida
NCT04931199
Enhancement of PTSD Treatment With Computerized Executive Function Training
VA Office of Research and Development
NCT03260127
Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans
VA Office of Research and Development
NCT00805532
Cognitive Training for PTSD
VA Office of Research and Development
NCT03316196
Remote Study of NightWare for PTSD With Nightmares
NightWare
NCT03934658
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
Multidisciplinary Association for Psychedelic Studies
NCT02759185
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
VA Office of Research and Development
NCT02641496
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
VA Office of Research and Development
NCT02391402
Improving Sleep to Reduce Risk for Substance Use Disorder
Florida State University
NCT03226132
Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
VA Office of Research and Development
NCT00701064
Writing Wrongs: Expressive Writing for Microaggressions
Auburn University
NCT06276725
Online Coping Skills Counseling for Problem Gambling and Trauma
University of Windsor
NCT03145792
Stepped Care for Young Children After Trauma
University of South Florida
NCT01603563
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Rush University Medical Center
NCT05534126
Brief Restructuring Intervention Following Trauma Exposure
University of Washington
NCT02808468
Mindfulness-Based Stress Reduction and the Microbiome
Seattle Institute for Biomedical and Clinical Research
NCT01619384
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
VA Office of Research and Development
NCT02248675
Using mHealth to Improve Emotional Recovery After Pediatric Injury
Medical University of South Carolina
NCT04579198
EEG Biofeedback in the Treatment of Chronic Treatment-Resistant PTSD
Justice Resource Institute
NCT01259921
Written Exposure in Substance Treatment
Potomac Health Foundations
NCT06296940
An Efficient Treatment for Posttraumatic Injury for Firefighters
Palo Alto Veterans Institute for Research
NCT05950035
rTMS for PTSD Comorbid With Major Depressive Disorder
Butler Hospital
NCT02273063
NightWare and Cardiovascular Health in Adults With PTSD
University of Colorado, Denver
NCT05365607
Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-traumatic Stress Disorder
Cedars-Sinai Medical Center
NCT00815204
Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
Research Foundation for Mental Hygiene
NCT01178671
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
VA Office of Research and Development
NCT02576899
An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military
University of Pennsylvania
NCT03337750
IOK Treatment Study
VA Office of Research and Development
NCT01605799
A Pilot Exercise Study for PTSD in Women Veterans
North Texas Veterans Healthcare System
NCT01892033
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 9 |
| Phase 3 | 3 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Posttraumatic Stress Disorder Trial Landscape
119 indexed Posttraumatic Stress Disorder studies · 39 recruiting (33%).
Phase mix: 9 late (III/IV) vs 16 early (I/II).
Top sponsor: VA Office of Research and Development (26 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Posttraumatic Stress Disorder?
PlainTrial tracks 119 US clinical trials for Posttraumatic Stress Disorder, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Posttraumatic Stress Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.