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ClinicalTrials.gov 4 recruiting now later-stage tilt small index

Periodontitis: later-stage trial registry

4 of 12 indexed Periodontitis trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #1,429 of 28,707 conditions by registered trial count.

12 US clinical trials · 4 currently recruiting · #1,429 of 28,707 conditions by registered trial count

Periodontitis: 12 US clinical trials tracked, 4 recruiting.

Periodontitis is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Texas A&M University, running 2 of these trials.

Enrollment posture brief

Registry condition periodontitis

OPEN 4 | RECR 33% | LATE 2 | EARLY 1 | RANK #1429 | SPON 2

Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)

Acute Myeloid Leukemia in Re41.7%Adenocarcinoma of the Rectum41.7%Periodontitis (this)33%Adherence, Patient16.7%Accelerated Phase Chronic My0%
Open-enrollment share among volume-matched conditions near Periodontitis

Periodontitis lists 4 open slots (33% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Periodontitis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Periodontitis is recruiting below its size-band peers.

    4 of 12 indexed trials (33.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Periodontitis research.

    Texas A&M University accounts for 2 of 12 trials (16.7%). 11 distinct sponsors appear on at least one study for this condition label.

  3. Typical Periodontitis enrolment sits around 128 participants.

    Median target enrolment is 128 among the 12 trials that report a genuine target (sentinel values excluded). 5 of those (41.7%) plan for fewer than 100 participants.

  4. Periodontitis research is mostly interventional.

    11 interventional and 1 observational studies make up this index (91.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 21Phase 32

Open and recent trials

12 total, page 1 of 1

RECRUITING Phase 3 150 participants

Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice

Rutgers, The State University of New Jersey

NCT06131021

RECRUITING NA 150 participants

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

Missouri Department of Health and Senior Services

NCT06890676

RECRUITING NA 70 participants

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Erchonia Corporation

NCT06656325

RECRUITING NA 32 participants

The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP

Texas A&M University

NCT05964699

ACTIVE NOT RECRUITING 110 participants

Effectiveness of Scaling and Root Planing in Deeper Pockets

Texas A&M University

NCT06890689

ACTIVE NOT RECRUITING NA 50 participants

Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

West Virginia University

NCT05422742

COMPLETED NA 180 participants

Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain

University of Michigan

NCT01530126

COMPLETED NA 175 participants

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

University of North Carolina, Chapel Hill

NCT02187185

COMPLETED Phase 2 154 participants

Microbial Associations in Periodontal Health and Disease

The Forsyth Institute

NCT00066001

COMPLETED Phase 3 128 participants

Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

OraPharma

NCT00371332

COMPLETED NA 44 participants

Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans

The University of Texas Health Science Center at San Antonio

NCT02154906

COMPLETED NA 21 participants

The Impact of a Modified Probe Tip Design on Patient Perception of Discomfort on Probing and Clinical Parameters Using the Florida Probe® System

University of Florida

NCT03690479

Phase Distribution

PhaseTrial count
Phase 2 1
Phase 3 2

Named interventions

Most-linked intervention names on Periodontitis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Minocycline HCL Microspheres Drug
1 trials
metronidazole Drug
1 trials
Manual Toothbrush Other
1 trials
Sonicare/Elite-Flexcare Toothbrush Other
1 trials
Ball Tip Probe Device
1 trials
Florida Probe Straight Tip Probe Device
1 trials
autologous platelet rich fibrin Device
1 trials
DFDBA Device
1 trials

US sites by state

Facility locations filed on Periodontitis trials. A trial with sites in several states counts in each.

Texas 3 trials
Massachusetts 3 trials
California 2 trials
West Virginia 1 trials
Tennessee 1 trials
New York 1 trials
North Carolina 1 trials
Missouri 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Periodontitis page

12 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Periodontitis condition card totals 12 registered trials; most-linked intervention Minocycline HCL Microspheres; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.