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Opiate Dependence
Open-data reference.
16 US clinical trials · 2 currently recruiting
Active & Recent Trials
Substance Abuse Pre-Treatment Screening Study
The University of Texas Health Science Center, Houston
NCT00439049
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
The University of Texas Medical Branch, Galveston
NCT07294118
Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence
Orexo AB
NCT01848054
Reengineering Methadone Treatment Study of Patient-centered Methadone Treatment
Friends Research Institute
NCT01442493
Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment
Albert Einstein College of Medicine
NCT01376570
Linking Hospitalized Injection Drug Users to Buprenorphine
Butler Hospital
NCT00987961
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
Yale University
NCT00580827
Comparison of HIV Clinic-based Treatment With Buprenorphine Versus Referred Care in Heroin-dependent Participants
Johns Hopkins University
NCT00130819
Cocaine Withdrawal and Pharmacotherapy Response
Yale University
NCT00566969
Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone
New York State Psychiatric Institute
NCT00577408
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
Yale University
NCT03527485
Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Wake Forest University Health Sciences
NCT04156802
Employment-Based Depot Naltrexone Clinical Trial II
Johns Hopkins University
NCT00684775
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03662529
Remote Observed Dosing of Suboxone to Improve Clinical Practice
University of Pennsylvania
NCT03769025
Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence
Rhode Island Hospital
NCT02602795
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Opiate Dependence Trial Landscape
ClinicalTrials.gov lists 16 US studies indexed under Opiate Dependence, and 2 of those are currently open to recruitment — roughly 13% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Opiate Dependence shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Opiate Dependence is led by Yale University with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Opiate Dependence?
PlainTrial tracks 16 US clinical trials for Opiate Dependence, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Opiate Dependence?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.