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ACTIVE NOT RECRUITING Phase 2

Phase 2b Study of GSK4532990 in Adults With NASH

NCT05583344 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4). The study duration will be up to 76 weeks including the screening period. The treatment duration will be up to 52 weeks.

Interventions

  • DRUG Placebo
  • DRUG GSK4532990

Study Locations (20)

California

  • GSK Investigational Site — Huntington Park
  • GSK Investigational Site — La Jolla
  • GSK Investigational Site — Orange
  • GSK Investigational Site — Poway
  • GSK Investigational Site — Rialto
  • GSK Investigational Site — Sacramento
  • GSK Investigational Site — San Francisco
  • GSK Investigational Site — Santa Ana
  • GSK Investigational Site — Van Nuys

Florida

  • GSK Investigational Site — Bradenton
  • GSK Investigational Site — Coral Gables
  • GSK Investigational Site — Fort Myers
  • GSK Investigational Site — Hallandale

Arizona

  • GSK Investigational Site — Chandler
  • GSK Investigational Site — Chandler
  • GSK Investigational Site — Mesa

Arkansas

  • GSK Investigational Site — Jonesboro
  • GSK Investigational Site — North Little Rock

Alabama

  • GSK Investigational Site — Homewood

Colorado

  • GSK Investigational Site — Colorado Springs

Trial Details

FieldValue
Enrollment Target 284 participants
Start Date 2023-01-02
Est. Completion 2027-04-05
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05583344

The ClinicalTrials.gov registry entry for NCT05583344 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 284 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Non-alcoholic Fatty Liver Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05583344 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05583344 about?

NCT05583344 is a clinical study titled "Phase 2b Study of GSK4532990 in Adults With NASH". The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4). The study duration will be up to 76 weeks including the screening period. The treatment duration will be...

What is the current status of trial NCT05583344?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 284 participants. The study started on 2023-01-02. Estimated completion is 2027-04-05.

What conditions does trial NCT05583344 study?

This clinical trial studies the following conditions: Non-alcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05583344?

The interventions under investigation include: Placebo (DRUG), GSK4532990 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05583344?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05583344 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial