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NCT01966627 · ClinicalTrials.gov registry record

Genetics of Fatty Liver Disease in Children

A clinical trial of Non-alcoholic Fatty Liver Disease, sponsored by Yale University.

Completed
Registry status
381
Enrollment target
1
Study location

NCT01966627 is a study of Non-alcoholic Fatty Liver Disease that has completed, run by Yale University. The registered enrollment target is 381 participants, above the 182-participant average among 50 other Non-alcoholic Fatty Liver Disease trials with a reported enrollment target (109% higher). The trial reports 1 study location across 1 state.

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The verdict

NCT01966627, a study of Non-alcoholic Fatty Liver Disease, has completed, sponsored by Yale University.

COMPLETED
Registry status
381 participants
Enrollment target
1
Study location

Study Summary

This is a study to investigate genetic predisposition to hepatic steatosis and the expression of gluconeogenic and lipogenic genes in livers of obese children and adolescents. Hypothesis 1: Common variants recently associated with variation in plasma TG levels identified in Genome Wide Association Studies (GWAS) (such as GCKR, PNPLA3) can affect accumulation of fat and subsequent development of Non Alcoholic Fatty Liver Disease (NAFLD). Gene variants act in additive or synergistic manner with progressive liver fat accumulation per additional risk allele. Hypothesis 2: With increase in hepatic fat content NASH and fibrosis will increase. Furthermore, expression of lipogenic markers (SREBP1c) will increase.

Conditions Studied

Non-alcoholic Fatty Liver Disease

Interventions

  • OTHER stool sample
  • OTHER ogtt
  • OTHER genotyping
  • OTHER abdominal and liver magnetic resonance imaging
  • OTHER liver biopsy

Study Locations (1)

Connecticut

  • Yale University - New Haven

Trial Details

FieldValue
Enrollment Target 381 participants
Start Date 2011-07
Est. Completion 2017-07

Sponsor

Yale University

1,492 total trials

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What the Registry Record Tells You About NCT01966627

The ClinicalTrials.gov registry entry for NCT01966627 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 381 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 182-participant average among 50 other Non-alcoholic Fatty Liver Disease trials with a reported enrollment target (109% higher). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Non-alcoholic Fatty Liver Disease appearing as the primary indexed condition, and to 5 interventions - of which stool sample is the first listed.

NCT01966627 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.

Frequently Asked Questions

What is clinical trial NCT01966627 about?

NCT01966627 is a clinical study titled "Genetics of Fatty Liver Disease in Children". This is a study to investigate genetic predisposition to hepatic steatosis and the expression of gluconeogenic and lipogenic genes in livers of obese children and adolescents. Hypothesis 1: Common variants recently associated with variation in plasma TG levels identified in Genome Wide Association ...

What is the current status of trial NCT01966627?

This trial is currently completed. The enrollment target is 381 participants. The study started on 2011-07. Estimated completion is 2017-07.

What conditions does trial NCT01966627 study?

This clinical trial studies the following conditions: Non-alcoholic Fatty Liver Disease.

What interventions are being tested in trial NCT01966627?

The interventions under investigation include: stool sample (OTHER), ogtt (OTHER), genotyping (OTHER), abdominal and liver magnetic resonance imaging (OTHER), liver biopsy (OTHER).

Who is sponsoring clinical trial NCT01966627?

This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01966627 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.