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Neonatal Abstinence Syndrome clinical trials
2 of 18 indexed Neonatal Abstinence Syndrome trials are currently recruiting.
18 US clinical trials · 2 currently recruiting
Neonatal Abstinence Syndrome is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is T. John Winhusen, PhD, running 3 of these trials.
The research picture
Neonatal Abstinence Syndrome has 18 registered US clinical trials, 2 of them open to new participants right now, about 11% of the total.
- 2
- recruiting participants now
- 11%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 3
- top sponsor: T. John Winhusen, PhD
Active & Recent Trials
18 total, page 1 of 1
An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)
University of Pennsylvania
NCT06576323
MicroRNA Biomarkers for Neonatal Opioid Withdrawal Syndrome
Milton S. Hershey Medical Center
NCT05937594
Treatment of Neonatal Abstinence Syndrome With Clonidine Versus Morphine as Primary Therapy
The Cooper Health System
NCT03092011
Neurostimulation to Improve NOWS Outcomes
Spark Biomedical
NCT05129020
A Trial to Determine Weight Gain Benefits of Caloric Supplementation for NAS Infants
Yale University
NCT04419857
Effective Caregiving for Neonatal Abstinence Syndrome: Testing an Instructional Mobile Technology Platform for High-Risk Pregnant Women
Washington State University
NCT04783558
Medication Treatment for Opioid Use Disorder in Expectant Mothers
T. John Winhusen, PhD
NCT03918850
Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain
Henrietta Bada
NCT03396588
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study
T. John Winhusen, PhD
NCT03911466
RCT of High- vs. Standard-Calorie Formula for Methadone-Exposed Infants
University of Pittsburgh
NCT02178189
Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome
National Institute on Drug Abuse (NIDA)
NCT00510016
Role of Low Lactose Infant Formula In The Management of Neonatal Abstinence Syndrome
MetroHealth Medical Center
NCT03549936
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
T. John Winhusen, PhD
NCT03911739
Buprenorphine for the Treatment of Neonatal Abstinence Syndrome
Thomas Jefferson University
NCT00521248
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
Boston Medical Center
NCT03718104
Treatment of Neonatal Abstinence Syndrome
Eastern Maine Medical Center
NCT01723722
Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome
Indiana University
NCT04298853
Buprenorphine for Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines
Thomas Jefferson University
NCT01671410
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Neonatal Abstinence Syndrome Trial Landscape
18 indexed Neonatal Abstinence Syndrome studies · 2 recruiting (11%).
Phase mix: 5 late (III/IV) vs 4 early (I/II).
Top sponsor: T. John Winhusen, PhD (3 trials), 9 others listed. 18 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Neonatal Abstinence Syndrome?
PlainTrial tracks 18 US clinical trials for Neonatal Abstinence Syndrome, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Neonatal Abstinence Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.