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ClinicalTrials.gov 46 recruiting now official registry

Myelodysplastic Syndrome clinical trials

46 of 135 indexed Myelodysplastic Syndrome trials are currently recruiting.

135 US clinical trials · 46 currently recruiting

Myelodysplastic Syndrome is the subject of 135 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 121 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 33 of these trials.

The research picture

Myelodysplastic Syndrome has 135 registered US clinical trials, 46 of them open to new participants right now, about 34% of the total.

46
recruiting participants now
34%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
33
top sponsor: M.D. Anderson Cancer Center
Phase 157Phase 264Phase 37

Active & Recent Trials

135 total, page 3 of 3

COMPLETED Phase 2 72 participants

Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT00469014

COMPLETED Phase 2 71 participants

Decitabine and Gemtuzumab Ozogamicin in Acute Myelogenous Leukemia and High-risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00968071

COMPLETED Phase 2 67 participants

A Study of Decitabine Given Subcutaneously to Adults With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)

Eisai

NCT00619099

COMPLETED Phase 1 66 participants

A Phase I/II Study of MGCD0103 With Azacitidine in Patients With High-Risk Myelodysplastic Syndrome (MDS) or Acute Myelogenous Leukemia

Mirati Therapeutics

NCT00324220

COMPLETED Phase 2 65 participants

Oral Clofarabine Study in Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00299156

COMPLETED Phase 1 54 participants

Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

M.D. Anderson Cancer Center

NCT01904136

COMPLETED Phase 1 51 participants

Idarubicin + Cytarabine and Lenalidomide in Patients With Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML)

H. Lee Moffitt Cancer Center and Research Institute

NCT00831766

COMPLETED Phase 2 51 participants

INCB018424 in Patients With Advanced Hematologic Malignancies

M.D. Anderson Cancer Center

NCT00674479

COMPLETED Phase 2 50 participants

Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01812252

COMPLETED Phase 1 47 participants

A Novel Sequential Treatment of Salvage and Reduced Intensity Conditioning (RIC) Chemotherapy for Allogeneic Stem-Cell Transplantation (SCT) for Primary Refractory and Relapsed Acute Myelogenous Leukemia (AML)

Weill Medical College of Cornell University

NCT00875693

COMPLETED Phase 2 46 participants

T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts

Baylor College of Medicine

NCT00368355

COMPLETED Phase 1 38 participants

Blinded Cross-Over Bioequivalence (BE) Trial of Luitpold Azacitidine vs Vidaza

American Regent

NCT01290302

COMPLETED Phase 1 36 participants

Study of 72-Hour Infusion of ON 01910.Na in Patients With MDS or AML

Traws Pharma

NCT00854945

COMPLETED Phase 1 36 participants

Phase I/II Study of 5-Azacytidine With Ara-C in Patients With Relapsed/Refractory Acute Myelogenous Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT00569010

COMPLETED Phase 1 36 participants

Safety and Pharmacokinetic Study of Oral ON 01910.Na in Patients With Myelodysplastic Syndrome

Traws Pharma

NCT01048619

COMPLETED Phase 2 34 participants

Phase II 5-Azacytidine Plus VPA Plus ATRA

M.D. Anderson Cancer Center

NCT00326170

COMPLETED Early Phase 1 30 participants

Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies

National Cancer Institute (NCI)

NCT00013533

COMPLETED Phase 2 26 participants

SCT Plus Immune Therapy in Average Risk AML/MDS

New York Medical College

NCT02117297

COMPLETED Phase 2 25 participants

Phase II Study of Azacitidine and Sargramostim as Maintenance Treatment for Poor-Risk AML or MDS

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01700673

COMPLETED Phase 2 25 participants

Immunochemotherapy and AlloSCT in Patients With High Risk CD33+ AML/MDS

New York Medical College

NCT02221310

COMPLETED Phase 2 25 participants

Reduced Intensity Conditioning Transplant Using Haploidentical Donors

Northside Hospital

NCT02581007

COMPLETED Phase 2 25 participants

NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid Diseases

Masonic Cancer Center, University of Minnesota

NCT01370213

COMPLETED Phase 2 24 participants

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

M.D. Anderson Cancer Center

NCT05115630

COMPLETED Phase 1 22 participants

Dose Escalation Trial of WT1-Sensitized T Cells for Residual or Relapsed Leukemia After Allogeneic Hematopoietic Progenitor Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT00620633

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

COMPLETED Phase 2 18 participants

Study to Determine the Safety and Preliminary Efficacy of CC-1088 in the Treatment of Myelodysplastic Syndromes

Celgene

NCT00045786

COMPLETED Phase 1 15 participants

Alloreactive NK Cells for Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT00402558

COMPLETED Phase 2 14 participants

Leucovorin for the Treatment of 5 q Minus Syndrome

National Institutes of Health Clinical Center (CC)

NCT00004997

COMPLETED Phase 2 14 participants

Efficacy and Safety of ON 01910.Na in Myelodysplastic Syndrome (MDS) Patients With Trisomy 8 or Classified as Intermediate-1, -2 or High Risk

Traws Pharma

NCT00906334

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

COMPLETED Phase 2 12 participants

Study of Clinical Efficacy and Safety of Tosedostat in MDS

Weill Medical College of Cornell University

NCT02452346

COMPLETED NA 12 participants

Decitabine and Cytarabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia, High Risk Myelodysplastic Syndrome, or Myeloproliferative Neoplasm

University of Washington

NCT02121418

COMPLETED Phase 1 10 participants

Infusion of Specially Treated Umbilical Cord Stem Cells After Chemoradiation Treatment for Blood Cancers

ViaCell

NCT00089596

COMPLETED Phase 1 10 participants

Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization

Jennifer Woyach

NCT04439006

COMPLETED Phase 2 4 participants

Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy

National Heart, Lung, and Blood Institute (NHLBI)

NCT00433745

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Phase Distribution

PhaseTrial count
Phase 1 57
Phase 2 64
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelodysplastic Syndrome Trial Landscape

135 indexed Myelodysplastic Syndrome studies · 46 recruiting (34%).

Phase mix: 7 late (III/IV) vs 121 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (33 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelodysplastic Syndrome?

PlainTrial tracks 135 US clinical trials for Myelodysplastic Syndrome, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelodysplastic Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.