Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Metastatic Prostate Carcinoma

Open-data reference.

38 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 804 participants

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

ECOG-ACRIN Cancer Research Group

NCT04423211

RECRUITING NA 800 participants

Access to Genetic Testing in Underserved Patients With Cancer

University of Southern California

NCT06422455

RECRUITING Early Phase 1 220 participants

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Mayo Clinic

NCT05045066

RECRUITING Phase 2 210 participants

Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

City of Hope Medical Center

NCT05869682

RECRUITING Phase 2 125 participants

FDG-PET-Guided Metastasis Directed Radiation Therapy for the Treatment of Metastatic Hormone Sensitive Prostate Cancer, The PRTY Trial

Northwestern University

NCT06244004

RECRUITING NA 120 participants

Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

Thomas Jefferson University

NCT05487846

RECRUITING NA 80 participants

Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial

Dana-Farber Cancer Institute

NCT06040125

RECRUITING 48 participants

Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

University of Washington

NCT04489719

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 2 38 participants

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

Mayo Clinic

NCT07073794

RECRUITING Phase 1 30 participants

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Jonsson Comprehensive Cancer Center

NCT05398302

RECRUITING 30 participants

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Thomas Jefferson University

NCT05627219

RECRUITING Phase 1 21 participants

PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

City of Hope Medical Center

NCT05805371

RECRUITING Phase 1 14 participants

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

Roswell Park Cancer Institute

NCT06305598

ACTIVE NOT RECRUITING Phase 2 196 participants

Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT02703623

ACTIVE NOT RECRUITING Phase 1 173 participants

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT03217747

ACTIVE NOT RECRUITING Phase 2 120 participants

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

M.D. Anderson Cancer Center

NCT04592237

ACTIVE NOT RECRUITING Phase 4 100 participants

Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer

Northwestern University

NCT03016741

ACTIVE NOT RECRUITING 92 participants

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy

Mayo Clinic

NCT01953640

ACTIVE NOT RECRUITING Phase 2 90 participants

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

National Cancer Institute (NCI)

NCT02893917

ACTIVE NOT RECRUITING Phase 2 79 participants

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Alliance for Clinical Trials in Oncology

NCT05241860

ACTIVE NOT RECRUITING Phase 2 73 participants

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

National Cancer Institute (NCI)

NCT03517969

ACTIVE NOT RECRUITING Phase 2 70 participants

Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

Northwestern University

NCT03012321

ACTIVE NOT RECRUITING Phase 1 65 participants

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

M.D. Anderson Cancer Center

NCT04388852

ACTIVE NOT RECRUITING Phase 2 60 participants

Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer

M.D. Anderson Cancer Center

NCT03821792

ACTIVE NOT RECRUITING Phase 1 37 participants

Enzalutamide and Cabazitaxel in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer

OHSU Knight Cancer Institute

NCT02522715

ACTIVE NOT RECRUITING Phase 2 37 participants

Abiraterone Acetate, Niclosamide, and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer

Mamta Parikh

NCT02807805

ACTIVE NOT RECRUITING Phase 2 15 participants

68Ga-PSMA-11 PET for the Diagnosis of Metastatic Castration Resistant Prostate Cancer

Thomas Hope

NCT04716725

ACTIVE NOT RECRUITING Phase 2 14 participants

Trametinib in Treating Patients With Progressive Metastatic Hormone-Resistant Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT02881242

ACTIVE NOT RECRUITING Phase 1 14 participants

PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer

City of Hope Medical Center

NCT03873805

ACTIVE NOT RECRUITING Phase 2 7 participants

Advanced ChemoHormonal Therapy for Treatment Naive Metastatic Prostate Cancer

OHSU Knight Cancer Institute

NCT04267887

COMPLETED Phase 2 937 participants

68GA-PSMA-11 PET/CT Scan in Impacting Treatment Strategies for Patients With Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT04050215

COMPLETED Phase 2 54 participants

CYT107 After Vaccine Treatment (Provenge®) in Patients With Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT01881867

COMPLETED Phase 2 32 participants

Abiraterone Acetate in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

University of Washington

NCT01503229

COMPLETED Phase 1 26 participants

Cytoreductive Prostatectomy in Treating Patients With Newly Diagnosed, Metastatic Prostate Cancer

Rutgers, The State University of New Jersey

NCT02458716

COMPLETED Phase 2 17 participants

Gallium Ga 68-DOTATATE PET/CT in Diagnosing Patients With Metastatic Castration Resistant Prostate Cancer

Emory University

NCT03448458

COMPLETED Phase 2 14 participants

Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway

University of Washington

NCT02598895

COMPLETED Phase 2 2 participants

Sipuleucel-T With or Without Tasquinimod in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer

Roswell Park Cancer Institute

NCT02159950

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 20
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Prostate Carcinoma Trial Landscape

ClinicalTrials.gov lists 38 US studies indexed under Metastatic Prostate Carcinoma, and 14 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Prostate Carcinoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 29 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Prostate Carcinoma is led by M.D. Anderson Cancer Center with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 38 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Prostate Carcinoma?

PlainTrial tracks 38 US clinical trials for Metastatic Prostate Carcinoma, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Prostate Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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