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ACTIVE NOT RECRUITING Phase 2

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

NCT03517969 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies how well berzosertib (M6620) and carboplatin with or without docetaxel works in treating patients with castration-resistant prostate cancer that has spread to other places in the body (metastatic). M6620 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving M6620, carboplatin and docetaxel may work better in treating patients with metastatic castration-resistant prostate cancer compared to carboplatin and docetaxel alone.

Interventions

  • DRUG Carboplatin
  • DRUG Docetaxel
  • OTHER Laboratory Biomarker Analysis
  • DRUG Berzosertib

Study Locations (20)

Connecticut

  • Smilow Cancer Hospital-Derby Care Center — Derby
  • Smilow Cancer Hospital Care Center-Fairfield — Fairfield
  • Smilow Cancer Hospital Care Center - Guilford — Guilford
  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford
  • Smilow Cancer Center/Yale-New Haven Hospital — New Haven
  • Yale University — New Haven
  • Yale-New Haven Hospital North Haven Medical Center — North Haven
  • Smilow Cancer Hospital-Orange Care Center — Orange
  • Smilow Cancer Hospital-Torrington Care Center — Torrington
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull
  • Smilow Cancer Hospital-Waterbury Care Center — Waterbury
  • Smilow Cancer Hospital Care Center - Waterford — Waterford

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • UC San Diego Moores Cancer Center — La Jolla
  • University of California Davis Comprehensive Cancer Center — Sacramento

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston
  • Dana-Farber Cancer Institute — Boston

Colorado

  • UCHealth University of Colorado Hospital — Aurora

Michigan

  • Wayne State University/Karmanos Cancer Institute — Detroit

New Jersey

  • Rutgers Cancer Institute of New Jersey — New Brunswick

Trial Details

FieldValue
Enrollment Target 73 participants
Start Date 2019-05-29
Est. Completion 2026-04-03
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03517969

The ClinicalTrials.gov registry entry for NCT03517969 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 73 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Castration-Resistant Prostate Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03517969 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Connecticut, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03517969 about?

NCT03517969 is a clinical study titled "M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer". This phase II trial studies how well berzosertib (M6620) and carboplatin with or without docetaxel works in treating patients with castration-resistant prostate cancer that has spread to other places in the body (metastatic). M6620 may stop the growth of tumor cells by blocking some of the enzymes n...

What is the current status of trial NCT03517969?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 73 participants. The study started on 2019-05-29. Estimated completion is 2026-04-03.

What conditions does trial NCT03517969 study?

This clinical trial studies the following conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer AJCC v8. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03517969?

The interventions under investigation include: Carboplatin (DRUG), Docetaxel (DRUG), Laboratory Biomarker Analysis (OTHER), Berzosertib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03517969?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03517969 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial