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2026 data Public-data reference. official source

Metastatic Pancreatic Cancer

Open-data reference.

33 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 614 participants

A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

Astellas Pharma Global Development

NCT07409272

RECRUITING Phase 3 480 participants

The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer

Quercis Pharma

NCT06861088

RECRUITING Phase 2 332 participants

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

National Cancer Institute (NCI)

NCT01174121

RECRUITING Phase 1 116 participants

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT04222413

RECRUITING Phase 1 104 participants

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

UNC Lineberger Comprehensive Cancer Center

NCT06483555

RECRUITING Phase 2 89 participants

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Rahul Aggarwal

NCT03682289

RECRUITING Phase 1 71 participants

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

ImmunoGenesis

NCT06782555

RECRUITING Phase 1 40 participants

Nab-Paclitaxel + Cisplatin + Gemcitabine + TTF in pt. w/ Metastatic PAC

Mayo Clinic

NCT04605913

RECRUITING Phase 2 38 participants

Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04753879

RECRUITING NA 30 participants

Alpha Radiation Emitters Device for the Treatment of Pancreatic Cancer With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer

Alpha Tau Medical

NCT06698458

RECRUITING Phase 1 30 participants

Study of Effect of Azeliragon in Patients Refractory to Prior Treatment of Metastatic Pancreatic Cancer

Cantex Pharmaceuticals

NCT05766748

RECRUITING Early Phase 1 30 participants

First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer

University of California, Davis

NCT04665947

RECRUITING Phase 1 24 participants

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

General Oncology

NCT04150042

RECRUITING Phase 2 20 participants

The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation

Benjamin Spieler

NCT06843551

ACTIVE NOT RECRUITING Phase 2 393 participants

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

Astellas Pharma Global Development

NCT03816163

ACTIVE NOT RECRUITING Phase 2 37 participants

Redefining FOLFIORINOX in Older Pancreatic Cancer Patients

Fox Chase Cancer Center

NCT05360732

ACTIVE NOT RECRUITING Phase 2 30 participants

Proglumide and Chemotherapy for Metastatic Pancreatic Cancer

Georgetown University

NCT05827055

ACTIVE NOT RECRUITING Phase 2 30 participants

Nivolumab + Ipilimumab + Radiation in MSS Pancreatic Cancer

Massachusetts General Hospital

NCT04361162

ACTIVE NOT RECRUITING Phase 2 30 participants

Modified FOLFIRINOX Alternated With Biweekly Gemcitabine Plus Nab-Paclitaxel Untreated Pancreatic Cancer

Lyudmyla Berim

NCT04672005

ACTIVE NOT RECRUITING Phase 2 30 participants

Atezolizumab + Cabozantinib in Patients w/ Metastatic, Refractory Pancreatic Cancer

University of Arizona

NCT04820179

ACTIVE NOT RECRUITING Phase 2 29 participants

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Memorial Sloan Kettering Cancer Center

NCT06168812

ACTIVE NOT RECRUITING Phase 2 28 participants

Study of Combined SGT-53 Plus Gemcitabine/Nab-Paclitaxel for Metastatic Pancreatic Cancer

SynerGene Therapeutics

NCT02340117

ACTIVE NOT RECRUITING 24 participants

Early Treatment ctDNA Dynamics to Predict Response to Chemotherapy

Northwell Health

NCT07122466

ACTIVE NOT RECRUITING Phase 1 17 participants

Pancrelipase in People With Pancreatic Ductal Adenocarcinoma (PDAC)

Memorial Sloan Kettering Cancer Center

NCT05642962

COMPLETED Phase 2 279 participants

PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic Cancer

Halozyme Therapeutics

NCT01839487

COMPLETED NA 216 participants

Improving Informed Consent for Palliative Chemotherapy

Dana-Farber Cancer Institute

NCT02282722

COMPLETED Phase 2 75 participants

Study of Modified FOLFIRINOX in Advanced Pancreatic Cancer

Yale University

NCT01523457

COMPLETED Phase 2 58 participants

A Phase II, Trial of Ixabepilone Plus Cetuximab as First Line Therapy for Metastatic Pancreatic Cancer

R-Pharm

NCT00383149

COMPLETED Phase 2 50 participants

BrUOG 292: FOLFOX-A For Metastatic Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial

Brown University

NCT02080221

COMPLETED Phase 1 27 participants

Study of Low-Dose Fractionated Radiotherapy in Patients With Locally Advanced Metastatic Pancreatic Cancer

Fox Chase Cancer Center

NCT00761345

COMPLETED Phase 1 27 participants

A Trial of GW572016, Gemcitabine and Oxaliplatin for Metastatic Pancreaticobiliary Cancer Schema

Brown University

NCT00439179

COMPLETED Phase 2 18 participants

Niraparib + Dostarlimab + RT in Pancreatic Cancer

Massachusetts General Hospital

NCT04409002

COMPLETED NA 10 participants

EL CENTRO: Engaging Latinos in the Center of Cancer Treatment Options

Dana-Farber Cancer Institute

NCT03602885

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 17
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Pancreatic Cancer Trial Landscape

ClinicalTrials.gov lists 33 US studies indexed under Metastatic Pancreatic Cancer, and 14 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Pancreatic Cancer shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Pancreatic Cancer is led by Fox Chase Cancer Center with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 33 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Pancreatic Cancer?

PlainTrial tracks 33 US clinical trials for Metastatic Pancreatic Cancer, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Pancreatic Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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