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ClinicalTrials.gov 7 recruiting now official registry

Metastatic Lung Cancer clinical trials

7 of 11 indexed Metastatic Lung Cancer trials are currently recruiting.

11 US clinical trials · 7 currently recruiting

Metastatic Lung Cancer is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics), running 2 of these trials.

The research picture

Metastatic Lung Cancer has 11 registered US clinical trials, 7 of them open to new participants right now, about 64% of the total.

7
recruiting participants now
64%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Phase 16Phase 22Phase 31

Active & Recent Trials

11 total, page 1 of 1

RECRUITING Phase 1 554 participants

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Institut de Recherches Internationales Servier

NCT05786924

RECRUITING Phase 1 392 participants

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06625775

RECRUITING Phase 1 250 participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06343402

RECRUITING NA 100 participants

Exercise as Maintenance Therapy in Advanced Lung Cancer

Indiana University

NCT06513663

RECRUITING Phase 2 90 participants

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

Mirati Therapeutics

NCT05609578

RECRUITING Phase 1 52 participants

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

Obsidian Therapeutics

NCT06060613

RECRUITING Phase 2 26 participants

Definitive Radiation for High-Risk Spine Metastases

Stony Brook University

NCT06165419

ACTIVE NOT RECRUITING Phase 1 200 participants

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Black Diamond Therapeutics

NCT05256290

COMPLETED Phase 1 62 participants

Irradiation of Large Lung Tumors or Two or More Lung Metastases Simultaneously

The Netherlands Cancer Institute

NCT01543672

COMPLETED 24 participants

Immune Response Under Immunotherapy in Metastatic NSCLC: Sputum, Blood Samples and Microbioata Study

University Hospital, Tours

NCT04804137

COMPLETED Phase 3 5 participants

Immunotherapy With or Without SBRT in Patients With Stage IV Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT03867175

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Lung Cancer Trial Landscape

11 indexed Metastatic Lung Cancer studies · 7 recruiting (64%).

Phase mix: 1 late (III/IV) vs 8 early (I/II).

Top sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) (2 trials), 9 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Lung Cancer?

PlainTrial tracks 11 US clinical trials for Metastatic Lung Cancer, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.