Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 11 recruiting now official registry

Metastatic Castration-Resistant Prostate Cancer (mCRPC) clinical trials

11 of 16 indexed Metastatic Castration-Resistant Prostate Cancer (mCRPC) trials are currently recruiting.

16 US clinical trials · 11 currently recruiting

Metastatic Castration-Resistant Prostate Cancer (mCRPC) is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis Pharmaceuticals, running 2 of these trials.

The research picture

Metastatic Castration-Resistant Prostate Cancer (mCRPC) has 16 registered US clinical trials, 11 of them open to new participants right now, about 69% of the total.

11
recruiting participants now
69%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: Novartis Pharmaceuticals
Phase 19Phase 24Phase 32Phase 41

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 1 1,314 participants

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Exelixis

NCT05176483

RECRUITING Phase 3 1,314 participants

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Merck Sharp & Dohme

NCT06136650

RECRUITING Phase 1 453 participants

A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma

Pfizer

NCT03460977

RECRUITING Phase 2 400 participants

Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T

Dendreon

NCT06134232

RECRUITING Phase 1 345 participants

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

Regeneron Pharmaceuticals

NCT03972657

RECRUITING Phase 1 345 participants

A Study of NX-1607 in Adults With Advanced Malignancies

Nurix Therapeutics

NCT05107674

RECRUITING Phase 1 190 participants

AB-3028, a Programmable Circuit T Cell Therapy in Patients With Castration Resistant Prostate Cancer (CRPC)

Arsenal Biosciences

NCT07285694

RECRUITING Phase 1 144 participants

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

K36 Therapeutics

NCT07103018

RECRUITING Phase 1 99 participants

Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients

Charles Drew University of Medicine and Science

NCT06615752

RECRUITING Phase 2 20 participants

Study of Lutetium (177Lu) Vipivotide Tetraxetan in mCRPC Participants With Moderately and Severely Impaired and With Normal Renal Function

Novartis Pharmaceuticals

NCT06004661

RECRUITING Phase 1 13 participants

Sipuleucel-T Based Autologous Cellular Immunotherapy for Advanced Prostate Cancer

University of Oklahoma

NCT05806814

ACTIVE NOT RECRUITING Phase 3 496 participants

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer

Jiangsu HengRui Medicine Co.

NCT04691804

ACTIVE NOT RECRUITING Phase 1 466 participants

Safety and Efficacy Study of NUV-1511 in Adult Patients With Advanced Solid Tumors

Nuvation Bio

NCT06334432

ACTIVE NOT RECRUITING Phase 2 170 participants

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

Xencor

NCT05032040

ACTIVE NOT RECRUITING Phase 2 7 participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI Versus AAA617 in PSMA Positive First-line mCRPC

Novartis Pharmaceuticals

NCT06894511

COMPLETED Phase 4 424 participants

A Study to Evaluate the Potential Increased Risk of Seizures Among Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients Treated With Enzalutamide

Astellas Pharma Global Development

NCT01977651

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 4
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Castration-Resistant Prostate Cancer (mCRPC) Trial Landscape

16 indexed Metastatic Castration-Resistant Prostate Cancer (mCRPC) studies · 11 recruiting (69%).

Phase mix: 3 late (III/IV) vs 13 early (I/II).

Top sponsor: Novartis Pharmaceuticals (2 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Castration-Resistant Prostate Cancer (mCRPC)?

PlainTrial tracks 16 US clinical trials for Metastatic Castration-Resistant Prostate Cancer (mCRPC), of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Castration-Resistant Prostate Cancer (mCRPC)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.