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2026 data Public-data reference. official source

Lupus Erythematosus, Systemic

Open-data reference.

30 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 600 participants

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

Janssen Research & Development

NCT07438496

RECRUITING Phase 3 420 participants

A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus

Viatris Innovation

NCT05648500

RECRUITING Phase 3 300 participants

A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment

Viatris Innovation

NCT07201129

RECRUITING NA 285 participants

Dose Response of Exercise for Arthritis Management

University of South Carolina

NCT06880653

RECRUITING 200 participants

Relationship Between Data Obtained With the LuGENE® Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients With SLE (ReLATE)

Ampel BioSolutions

NCT05845593

RECRUITING Phase 2 179 participants

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

Novartis Pharmaceuticals

NCT06581198

RECRUITING Phase 1 150 participants

A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

AstraZeneca

NCT06897930

RECRUITING NA 125 participants

Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

University of Michigan

NCT06208514

RECRUITING Phase 2 89 participants

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT07015983

RECRUITING Phase 1 80 participants

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

CRISPR Therapeutics

NCT06925542

RECRUITING Phase 4 30 participants

Trial of Belimumab in Early Lupus

Northwell Health

NCT03543839

ACTIVE NOT RECRUITING Phase 3 562 participants

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

Biogen

NCT04961567

ACTIVE NOT RECRUITING Phase 3 548 participants

A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

Biogen

NCT04895241

ACTIVE NOT RECRUITING Phase 3 451 participants

A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus

Viatris Innovation

NCT05672576

ACTIVE NOT RECRUITING NA 200 participants

Lupus Intervention for Fatigue Trial

Northwestern University

NCT02653287

ACTIVE NOT RECRUITING Phase 2 111 participants

Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus

Vanderbilt University Medical Center

NCT03527472

COMPLETED Phase 2 262 participants

A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus

Genentech

NCT00137969

COMPLETED Phase 3 221 participants

Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)

Laura Schanberg

NCT00065806

COMPLETED Phase 2 218 participants

An Open-label Study to Evaluate the Long-term Safety of MEDI-546, for the Treatment of SLE, in Adults

MedImmune

NCT01753193

COMPLETED Phase 2 214 participants

Study of VIB7734 for the Treatment of Moderate to Severely Active SLE

Amgen

NCT04925934

COMPLETED Phase 4 172 participants

Acthar Gel for Active Systemic Lupus Erythematosus (SLE)

Mallinckrodt

NCT02953821

COMPLETED NA 166 participants

Establishing Clinical Utility of a New Diagnostic Test for Rheumatology Patients

Qure Healthcare

NCT04266860

COMPLETED 97 participants

A Complex Contraception Registry

University of California, San Diego

NCT02219269

COMPLETED 77 participants

A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers

Janssen Research & Development

NCT02034344

COMPLETED Phase 2 54 participants

Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions

Rigel Pharmaceuticals

NCT01597050

COMPLETED Phase 1 30 participants

Study Evaluating The SBI-087 In Subjects With Systemic Lupus Erythematosus

Pfizer

NCT00714116

COMPLETED Phase 1 24 participants

Anti-CD20 in Systemic Lupus Erythematosus

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00036491

COMPLETED Phase 1 22 participants

Phase Ib Study of SC Milatuzumab in SLE

Gilead Sciences

NCT01845740

COMPLETED Phase 2 9 participants

Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus

National Cancer Institute (NCI)

NCT00076752

COMPLETED Phase 1 1 participants

Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis

Joseph B. Ciolino, MD

NCT01582880

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 8
Phase 3 7
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lupus Erythematosus, Systemic Trial Landscape

ClinicalTrials.gov lists 30 US studies indexed under Lupus Erythematosus, Systemic, and 11 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Lupus Erythematosus, Systemic shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Lupus Erythematosus, Systemic is led by Viatris Innovation with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lupus Erythematosus, Systemic?

PlainTrial tracks 30 US clinical trials for Lupus Erythematosus, Systemic, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lupus Erythematosus, Systemic?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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