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Lupus Erythematosus, Systemic
Open-data reference.
30 US clinical trials · 11 currently recruiting
Active & Recent Trials
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Janssen Research & Development
NCT07438496
A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus
Viatris Innovation
NCT05648500
A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment
Viatris Innovation
NCT07201129
Dose Response of Exercise for Arthritis Management
University of South Carolina
NCT06880653
Relationship Between Data Obtained With the LuGENE® Multiparameter Transcriptomics Blood Test and Clinical and Standard Laboratory Features of Patients With SLE (ReLATE)
Ampel BioSolutions
NCT05845593
A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)
Novartis Pharmaceuticals
NCT06581198
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
AstraZeneca
NCT06897930
Brief Pain Exposure Therapy (BPET) For Nociplastic Pain
University of Michigan
NCT06208514
A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
NCT07015983
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
NCT06925542
Trial of Belimumab in Early Lupus
Northwell Health
NCT03543839
A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
Biogen
NCT04961567
A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus
Biogen
NCT04895241
A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus
Viatris Innovation
NCT05672576
Lupus Intervention for Fatigue Trial
Northwestern University
NCT02653287
Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus
Vanderbilt University Medical Center
NCT03527472
A Study to Evaluate the Safety of Rituximab Retreatment in Subjects With Systemic Lupus Erythematosus
Genentech
NCT00137969
Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE)
Laura Schanberg
NCT00065806
An Open-label Study to Evaluate the Long-term Safety of MEDI-546, for the Treatment of SLE, in Adults
MedImmune
NCT01753193
Study of VIB7734 for the Treatment of Moderate to Severely Active SLE
Amgen
NCT04925934
Acthar Gel for Active Systemic Lupus Erythematosus (SLE)
Mallinckrodt
NCT02953821
Establishing Clinical Utility of a New Diagnostic Test for Rheumatology Patients
Qure Healthcare
NCT04266860
A Complex Contraception Registry
University of California, San Diego
NCT02219269
A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers
Janssen Research & Development
NCT02034344
Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions
Rigel Pharmaceuticals
NCT01597050
Study Evaluating The SBI-087 In Subjects With Systemic Lupus Erythematosus
Pfizer
NCT00714116
Anti-CD20 in Systemic Lupus Erythematosus
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00036491
Phase Ib Study of SC Milatuzumab in SLE
Gilead Sciences
NCT01845740
Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus
National Cancer Institute (NCI)
NCT00076752
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Joseph B. Ciolino, MD
NCT01582880
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Lupus Erythematosus, Systemic Trial Landscape
ClinicalTrials.gov lists 30 US studies indexed under Lupus Erythematosus, Systemic, and 11 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Lupus Erythematosus, Systemic shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Lupus Erythematosus, Systemic is led by Viatris Innovation with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Lupus Erythematosus, Systemic?
PlainTrial tracks 30 US clinical trials for Lupus Erythematosus, Systemic, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Lupus Erythematosus, Systemic?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.