Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Loneliness clinical trials
Every US clinical trial registered for Loneliness — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
36 US clinical trials · 11 currently recruiting
The research picture
Loneliness has 36 registered US clinical trials, 11 of them open to new participants right now — about 31% of the total.
- 11
- recruiting participants now
- 31%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 5
- top sponsor: University of Rochester
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study
Aura
NCT06664944
Intervening on Opioid Use and Loneliness
University of Rochester
NCT06458335
How is Social Connection Represented in the Brain?
Columbia University
NCT04577911
Need to be Needed (N2BN) Intervention
Temple University
NCT06510439
Reduce Loneliness in Care Partners of Persons With AD/ADRD
Northwell Health
NCT05460494
Improving Social Connectedness Through Digital Health to Enhance Recovery from OUD Among the Justice Involved Population
Rhode Island Hospital
NCT06896656
LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation
Cedars-Sinai Medical Center
NCT05831475
Fostering Agricultural Relationships and Meaning - Thriving on Kinship
Ohio State University
NCT07218965
Testing Adapted Self-Help Plus (SH+) for Stress and Well-Being in International Students at a U.S. University
The New School
NCT07188467
A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults
Montefiore Medical Center
NCT06919094
The VESPA Pilot Study
Wake Forest University
NCT04756245
Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial
VA Office of Research and Development
NCT05484297
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults
University of California, San Francis
NCT05645835
SSIs for Mental Health and Loneliness
University of California, Irvine
NCT05687162
A Smartphone Intervention for Relational and Mental Well Being
University of Washington
NCT04629755
Social Activity, Loneliness and Stigma During COVID-19 Outbreak
Columbia University
NCT04734171
Testing the Effectiveness of an Online Behavioral Intervention in Reducing Loneliness
Happify
NCT04112225
The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)
University of Florida
NCT07204444
Rural Dementia Caregiver Project
University of California, San Francis
NCT04428112
Telephone Calls for Health for Homebound Older Adults
University of Texas at Austin
NCT04595708
Stress Management Training for Healthy Aging
Carnegie Mellon University
NCT02888600
Technology and Family Thriving Study
University of California, Santa Barbara
NCT05150990
Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians
University of Colorado, Denver
NCT05635448
The Association Between Loneliness and Substance Use
University of Rochester
NCT04938492
Mindfulness-Based College: Stage 1
Brown University
NCT03124446
"Recovery 4 US" - A Photovoice-based Social Media Program
Boston University Charles River Campus
NCT03266614
The Loneliness Epidemic Tailoring Interventions to Reduce Loneliness and Pain
University of Nebraska
NCT05387447
Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation
Baycrest
NCT03972787
Culture and Well-Being for Latinos
University of Rochester
NCT05244733
Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults
University of Washington
NCT04966910
Daily Study of Caregiving Relationships and Health
The University of Texas Health Science Center at San Antonio
NCT04682535
Study 1: Social Engage Coaching R61 Phase
University of Rochester
NCT05745493
VOICES Socials for Older Veterans With Depression
VA Office of Research and Development
NCT06145334
Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders
University of South Florida
NCT03552328
Connect for Caregivers
University of Rochester
NCT04919070
Phase Distribution
Phase data not available
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Loneliness Trial Landscape
ClinicalTrials.gov lists 36 US studies indexed under Loneliness, and 11 of those are currently open to recruitment — roughly 31% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Loneliness shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Loneliness is led by University of Rochester with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Loneliness?
PlainTrial tracks 36 US clinical trials for Loneliness, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Loneliness?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.