Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Loneliness clinical trials
11 of 36 indexed Loneliness trials are currently recruiting.
Corpus placement: #419 of 28,707 conditions by registered trial count.
36 US clinical trials · 11 currently recruiting · #419 of 28,707 conditions by registered trial count
Loneliness: 36 US clinical trials tracked, 11 recruiting.
Loneliness is the subject of 36 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. The most active sponsor is University of Rochester, running 5 of these trials.
Enrollment posture brief
Registry condition loneliness
OPEN 11 | RECR 31% | LATE 0 | EARLY 0 | RANK #419 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Arthritis (31% recruiting · 49 trials)
Loneliness lists 11 open slots (31% of 36 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Loneliness on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Loneliness is recruiting below its size-band peers.
11 of 36 indexed trials (30.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Loneliness trials is spread across many organizations.
University of Rochester accounts for 5 of 36 trials (13.9%). 28 distinct sponsors appear on at least one study for this condition label.
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Typical Loneliness enrolment sits around 96 participants.
Median target enrolment is 96 among the 36 trials that report a genuine target (sentinel values excluded). 19 of those (52.8%) plan for fewer than 100 participants.
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Loneliness research is mostly interventional.
33 interventional and 3 observational studies make up this index (91.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
36 total, page 1 of 1
Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study
Aura
NCT06664944
Intervening on Opioid Use and Loneliness
University of Rochester
NCT06458335
How is Social Connection Represented in the Brain?
Columbia University
NCT04577911
Need to be Needed (N2BN) Intervention
Temple University
NCT06510439
Reduce Loneliness in Care Partners of Persons With AD/ADRD
Northwell Health
NCT05460494
Improving Social Connectedness Through Digital Health to Enhance Recovery from OUD Among the Justice Involved Population
Rhode Island Hospital
NCT06896656
LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation
Cedars-Sinai Medical Center
NCT05831475
Fostering Agricultural Relationships and Meaning - Thriving on Kinship
Ohio State University
NCT07218965
Testing Adapted Self-Help Plus (SH+) for Stress and Well-Being in International Students at a U.S. University
The New School
NCT07188467
A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults
Montefiore Medical Center
NCT06919094
The VESPA Pilot Study
Wake Forest University
NCT04756245
Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial
VA Office of Research and Development
NCT05484297
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults
University of California, San Francisco
NCT05645835
SSIs for Mental Health and Loneliness
University of California, Irvine
NCT05687162
A Smartphone Intervention for Relational and Mental Well Being
University of Washington
NCT04629755
Social Activity, Loneliness and Stigma During COVID-19 Outbreak
Columbia University
NCT04734171
Testing the Effectiveness of an Online Behavioral Intervention in Reducing Loneliness
Happify
NCT04112225
The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)
University of Florida
NCT07204444
Rural Dementia Caregiver Project
University of California, San Francisco
NCT04428112
Telephone Calls for Health for Homebound Older Adults
University of Texas at Austin
NCT04595708
Stress Management Training for Healthy Aging
Carnegie Mellon University
NCT02888600
Technology and Family Thriving Study
University of California, Santa Barbara
NCT05150990
Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians
University of Colorado, Denver
NCT05635448
The Association Between Loneliness and Substance Use
University of Rochester
NCT04938492
Mindfulness-Based College: Stage 1
Brown University
NCT03124446
"Recovery 4 US" - A Photovoice-based Social Media Program
Boston University Charles River Campus
NCT03266614
The Loneliness Epidemic Tailoring Interventions to Reduce Loneliness and Pain
University of Nebraska
NCT05387447
Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation
Baycrest
NCT03972787
Culture and Well-Being for Latinos
University of Rochester
NCT05244733
Stay Connected: Testing an Intervention to Combat Coronavirus-related Social Isolation Among Older Adults
University of Washington
NCT04966910
Daily Study of Caregiving Relationships and Health
The University of Texas Health Science Center at San Antonio
NCT04682535
Study 1: Social Engage Coaching R61 Phase
University of Rochester
NCT05745493
VOICES Socials for Older Veterans With Depression
VA Office of Research and Development
NCT06145334
Effects of a Volunteer-based Lunch Program on Feelings of Loneliness in Elders
University of South Florida
NCT03552328
Connect for Caregivers
University of Rochester
NCT04919070
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on Loneliness records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Loneliness trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Loneliness page
36 registered trials, 11 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 11 Loneliness trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Rochester sponsors the most Loneliness trials on record, review their full trial history before evaluating a specific study. See University of Rochester's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Loneliness condition card totals 36 registered trials; most-linked intervention Health Education; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.