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ClinicalTrials.gov 3 recruiting now official registry

Lennox Gastaut Syndrome clinical trials

3 of 11 indexed Lennox Gastaut Syndrome trials are currently recruiting.

11 US clinical trials · 3 currently recruiting

Lennox Gastaut Syndrome is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Longboard Pharmaceuticals, running 2 of these trials.

The research picture

Lennox Gastaut Syndrome has 11 registered US clinical trials, 3 of them open to new participants right now, about 27% of the total.

3
recruiting participants now
27%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
2
top sponsor: Longboard Pharmaceuticals
Phase 13Phase 22Phase 34Phase 41

Active & Recent Trials

11 total, page 1 of 1

RECRUITING 4,680 participants

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05374824

RECRUITING Phase 3 260 participants

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

Epygenix

NCT05066217

RECRUITING Phase 3 252 participants

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

SK Life Science

NCT05219617

ACTIVE NOT RECRUITING Phase 4 154 participants

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Jazz Pharmaceuticals

NCT05044819

ACTIVE NOT RECRUITING Phase 2 24 participants

RNS System LGS Feasibility Study

NeuroPace

NCT05339126

COMPLETED Phase 3 412 participants

A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

Zogenix

NCT03936777

COMPLETED Phase 3 171 participants

A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults

Jazz Pharmaceuticals

NCT02224690

COMPLETED Phase 1 52 participants

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies

Longboard Pharmaceuticals

NCT05364021

COMPLETED Phase 2 41 participants

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Longboard Pharmaceuticals

NCT05626634

COMPLETED Phase 1 15 participants

Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome

SK Life Science

NCT04062981

COMPLETED Phase 1 9 participants

A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking Cannabidiol

Zogenix International Limited, Inc., a subsidiary of Zogenix

NCT03467113

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 3 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lennox Gastaut Syndrome Trial Landscape

11 indexed Lennox Gastaut Syndrome studies · 3 recruiting (27%).

Phase mix: 5 late (III/IV) vs 5 early (I/II).

Top sponsor: Longboard Pharmaceuticals (2 trials), 7 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lennox Gastaut Syndrome?

PlainTrial tracks 11 US clinical trials for Lennox Gastaut Syndrome, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lennox Gastaut Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.