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ClinicalTrials.gov 3 recruiting now full pipeline small index

Lennox Gastaut Syndrome: full-pipeline trial registry

3 of 11 indexed Lennox Gastaut Syndrome trials are currently recruiting.

Corpus placement: #1,577 of 28,707 conditions by registered trial count.

11 US clinical trials · 3 currently recruiting · #1,577 of 28,707 conditions by registered trial count

Lennox Gastaut Syndrome: 11 US clinical trials tracked, 3 recruiting.

Lennox Gastaut Syndrome is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Longboard Pharmaceuticals, running 2 of these trials.

Enrollment posture brief

Registry condition lennox-gastaut-syndrome

OPEN 3 | RECR 27% | LATE 5 | EARLY 5 | RANK #1577 | SPON 2

Nearest open-share peer: Atherosclerotic Cardiovascular Disease (27% recruiting · 22 trials)

Acute Pancreatitis81.8%Acute Stroke45.5%Acquired Brain Injury36.4%Lennox Gastaut Syndrome (thi…27%Acute Lung Injury9.1%
Open-enrollment share among volume-matched conditions near Lennox Gastaut Syndrome

Lennox Gastaut Syndrome lists 3 open slots (27% of 11 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Lennox Gastaut Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Lennox Gastaut Syndrome is recruiting below its size-band peers.

    3 of 11 indexed trials (27.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Lennox Gastaut Syndrome research.

    Longboard Pharmaceuticals accounts for 2 of 11 trials (18.2%). 8 distinct sponsors appear on at least one study for this condition label.

  3. Typical Lennox Gastaut Syndrome enrolment sits around 154 participants.

    Median target enrolment is 154 among the 11 trials that report a genuine target (sentinel values excluded). 5 of those (45.5%) plan for fewer than 100 participants.

  4. Lennox Gastaut Syndrome research is mostly interventional.

    10 interventional and 1 observational studies make up this index (90.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 13Phase 22Phase 34Phase 41

Open and recent trials

11 total, page 1 of 1

RECRUITING 4,680 participants

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

Ann & Robert H Lurie Children's Hospital of Chicago

NCT05374824

RECRUITING Phase 3 260 participants

An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

Epygenix

NCT05066217

RECRUITING Phase 3 252 participants

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

SK Life Science

NCT05219617

ACTIVE NOT RECRUITING Phase 4 154 participants

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Jazz Pharmaceuticals

NCT05044819

ACTIVE NOT RECRUITING Phase 2 24 participants

RNS System LGS Feasibility Study

NeuroPace

NCT05339126

COMPLETED Phase 3 412 participants

A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

Zogenix

NCT03936777

COMPLETED Phase 3 171 participants

A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults

Jazz Pharmaceuticals

NCT02224690

COMPLETED Phase 1 52 participants

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies

Longboard Pharmaceuticals

NCT05364021

COMPLETED Phase 2 41 participants

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Longboard Pharmaceuticals

NCT05626634

COMPLETED Phase 1 15 participants

Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome

SK Life Science

NCT04062981

COMPLETED Phase 1 9 participants

A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking Cannabidiol

Zogenix International Limited, Inc., a subsidiary of Zogenix

NCT03467113

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 3 4
Phase 4 1

Named interventions

Most-linked intervention names on Lennox Gastaut Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
3 trials
Carisbamate Drug
2 trials
Cannabidiol Drug
2 trials
LP352, bexicaserin Drug
1 trials
ZX008 0.2 to 0.8 mg/kg/day Drug
1 trials
GWP42003-P 20 mg/kg/day Dose Drug
1 trials
RNS System Device
1 trials
ZX008 (Fenfluramine Hydrochloride) Drug
1 trials

US sites by state

Facility locations filed on Lennox Gastaut Syndrome trials. A trial with sites in several states counts in each.

New York 7 trials
Florida 7 trials
Minnesota 6 trials
Maryland 6 trials
California 6 trials
Missouri 5 trials
Illinois 5 trials
Georgia 5 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Lennox Gastaut Syndrome page

11 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Lennox Gastaut Syndrome condition card totals 11 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.