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Influenza clinical trials
27 of 157 indexed Influenza trials are currently recruiting.
157 US clinical trials · 27 currently recruiting
Influenza is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 73 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 36 of these trials.
The research picture
Influenza has 157 registered US clinical trials, 27 of them open to new participants right now, about 17% of the total.
- 27
- recruiting participants now
- 17%
- of trials open to enrollment
- 42
- in Phase 3–4 (later-stage)
- 36
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
157 total, page 3 of 4
2010-2011 Trivalent Influenza Vaccine (TIV) in Pregnant Women
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01173211
A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine
Vaxart
NCT02918006
Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms
Hoffmann-La Roche
NCT03629184
Immunogenicity and Safety of FluBlok Trivalent Recombinant Hemagglutinin Influenza Vaccine in Healthy Pediatrics
Protein Sciences Corporation
NCT00336453
A Study Evaluating the Safety and Tolerability of a Seasonal Influenza Vaccine Containing LIQ001
Liquidia Technologies
NCT01224262
Safety and Immunogenicity of Quadrivalent Recombinant Influenza Vaccine Formulations Containing Different H3 Hemagglutinin Antigens in Healthy Adult Subjects 18 to 30 Years of Age
Sanofi Pasteur, a Sanofi Company
NCT04144179
Proteomic Profiling for Influenza
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00133588
Study of an Investigational Monoclonal Antibody, VIS410, in Subjects With Uncomplicated Influenza A
Visterra
NCT02989194
Influenza Vaccination in the Emergency Department
University of Arizona
NCT00822627
Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza
BioCryst Pharmaceuticals
NCT02369159
Seasonal Influenza DNA Vaccine Prime With Trivalent Inactivated Vaccine (TIV) Boost Compared to TIV Alone
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01498718
Safety, Reactogenicity, and Immunogenicity of Inactivated Influenza A/H7/N7 Vaccine in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00546585
Influenza Vaccine in Lung Transplant Patients - Antibody
University of Wisconsin, Madison
NCT04533139
A Study to Evaluate the Safety and Immune Responses to Fluzone® Vaccination
Sanofi Pasteur, a Sanofi Company
NCT00743275
Immunologic Response to Inactivated Vaccine for Novel H1N1 Virus
University of Rochester
NCT01023711
Influenza Vaccine in Pregnant Women
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00905125
Safety and Dose Study of Peramivir for Influenza Treatment
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00297050
Inactivated Influenza A/H9N2 Vaccine With and Without MF59 Adjuvant in Ambulatory Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00133471
Collection of Serum Samples From Children and Older Adults Receiving the 2019-2020 Formulations of Fluzone® Quadrivalent and Fluzone® High-Dose Influenza Vaccines, Respectively
Sanofi Pasteur, a Sanofi Company
NCT04109222
Sanofi Pasteur Quadrivalent Intradermal Influenza Vaccine Pregnancy Registry
Sanofi Pasteur, a Sanofi Company
NCT02554409
Oseltamivir Treatment for Children Less Than 24 Months of Age With Influenza
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00391768
Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014)
Stanford University
NCT02141581
Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03845231
The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection
Stanford University
NCT03453801
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009
Stanford University
NCT01987349
Safety, Tolerability, and PK of Escalating Doses of Flufirvitide-3 Dry Powder for Inhalation in Healthy Subjects
Autoimmune Technologies
NCT01990846
Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent Influenza Virus Vaccine
Sanofi Pasteur, a Sanofi Company
NCT01946425
Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent, Influenza Vaccine
Sanofi Pasteur, a Sanofi Company
NCT02222870
Single-ascending-dose Study of the Safety and Immunogenicity of NasoVAX
Altimmune
NCT03232567
Elderly Influenza Vaccine Immunogenicity Substudy
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00170482
Evaluation of Free Air Portable Air Powered Respirator
Wake Forest University Health Sciences
NCT02487147
Phase 1 Safety and Immunogenicity Study in Healthy Adults of VAX125, a Recombinant HA-flagellin Influenza Vaccine
VaxInnate Corporation
NCT00730457
Study to Evaluate the Immune Responses of Trivalent Cold-Adapted Influenza Vaccine (CAIV-T) Compared With (TIV)
MedImmune
NCT00111579
Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing In Gammopathy Patients
Yale University
NCT02267733
B-cell Immunity to Influenza (SLVP017)- Year 1, 2009
Stanford University
NCT02133781
Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure
GlaxoSmithKline
NCT01788228
Influenza A 2009 H1N1 Challenge Study in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01646138
Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01578317
A Study of VIS410 to Assess Safety and Pharmacokinetics
Visterra
NCT02045472
Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children
University of Rochester
NCT01246999
Phase IV Trial to Collect Safety Data and Sera for Immunogenicity Testing in Healthy Children Given Fluzone® Vaccine
Sanofi Pasteur, a Sanofi Company
NCT00561002
Phase II Study to Investigate the Kinetics of the Immune Response Generated by Influenza Virus Vaccine.
MedImmune
NCT00192309
Anti-Influenza Hyperimmune Intravenous Immunoglobulin Pilot Study (INSIGHT 005: Flu-IVIG Pilot)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02008578
Safety of and Immune Response to a Bird Flu Virus Vaccine (H9N2) in Healthy Adults (Study A)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00110279
Safety of Lactobacillus Rhamnosus GG Versus Placebo in Elderly Subjects Receiving Live Attenuated Influenza Vaccine
Patricia L. Hibberd
NCT01545349
H7N9 Boost in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02586792
Safety, Tolerability, and Pharmacokinetics of SAB-176 in Healthy Participants
SAb Biotherapeutics
NCT04471038
Safety and Immune Response to Recombinant Live-Attenuated Influenza H2N2 Virus Vaccine
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00722774
Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly
Mayo Clinic
NCT01304771
Safety of and Immune Response to Recombinant Live-Attenuated Influenza H6N1 Virus Vaccine Vaccine
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00734175
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 31 |
| Phase 3 | 17 |
| Phase 4 | 25 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Influenza Trial Landscape
157 indexed Influenza studies · 27 recruiting (17%).
Phase mix: 42 late (III/IV) vs 73 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (36 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Influenza?
PlainTrial tracks 157 US clinical trials for Influenza, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Influenza?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.