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ClinicalTrials.gov 27 recruiting now official registry

Influenza clinical trials

27 of 157 indexed Influenza trials are currently recruiting.

157 US clinical trials · 27 currently recruiting

Influenza is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 42 are in Phase 3-4 (later-stage) and 73 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 36 of these trials.

The research picture

Influenza has 157 registered US clinical trials, 27 of them open to new participants right now, about 17% of the total.

27
recruiting participants now
17%
of trials open to enrollment
42
in Phase 3–4 (later-stage)
36
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 142Phase 231Phase 317Phase 425

Active & Recent Trials

157 total, page 3 of 4

COMPLETED Phase 2 183 participants

2010-2011 Trivalent Influenza Vaccine (TIV) in Pregnant Women

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01173211

COMPLETED Phase 2 179 participants

A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine

Vaxart

NCT02918006

COMPLETED Phase 3 173 participants

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms

Hoffmann-La Roche

NCT03629184

COMPLETED Phase 1 156 participants

Immunogenicity and Safety of FluBlok Trivalent Recombinant Hemagglutinin Influenza Vaccine in Healthy Pediatrics

Protein Sciences Corporation

NCT00336453

COMPLETED Phase 1 152 participants

A Study Evaluating the Safety and Tolerability of a Seasonal Influenza Vaccine Containing LIQ001

Liquidia Technologies

NCT01224262

COMPLETED Phase 1 150 participants

Safety and Immunogenicity of Quadrivalent Recombinant Influenza Vaccine Formulations Containing Different H3 Hemagglutinin Antigens in Healthy Adult Subjects 18 to 30 Years of Age

Sanofi Pasteur, a Sanofi Company

NCT04144179

COMPLETED Phase 4 150 participants

Proteomic Profiling for Influenza

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00133588

COMPLETED Phase 2 150 participants

Study of an Investigational Monoclonal Antibody, VIS410, in Subjects With Uncomplicated Influenza A

Visterra

NCT02989194

COMPLETED NA 140 participants

Influenza Vaccination in the Emergency Department

University of Arizona

NCT00822627

COMPLETED Phase 3 137 participants

Safety, PK and Effectiveness of IV Peramivir Versus Oseltamivir in Pediatric Subjects With Uncomplicated Influenza

BioCryst Pharmaceuticals

NCT02369159

COMPLETED Phase 1 131 participants

Seasonal Influenza DNA Vaccine Prime With Trivalent Inactivated Vaccine (TIV) Boost Compared to TIV Alone

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01498718

COMPLETED Phase 1 126 participants

Safety, Reactogenicity, and Immunogenicity of Inactivated Influenza A/H7/N7 Vaccine in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00546585

COMPLETED 122 participants

Influenza Vaccine in Lung Transplant Patients - Antibody

University of Wisconsin, Madison

NCT04533139

COMPLETED Phase 4 120 participants

A Study to Evaluate the Safety and Immune Responses to Fluzone® Vaccination

Sanofi Pasteur, a Sanofi Company

NCT00743275

COMPLETED NA 107 participants

Immunologic Response to Inactivated Vaccine for Novel H1N1 Virus

University of Rochester

NCT01023711

COMPLETED Phase 2 102 participants

Influenza Vaccine in Pregnant Women

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00905125

COMPLETED Phase 1 100 participants

Safety and Dose Study of Peramivir for Influenza Treatment

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00297050

COMPLETED Phase 1 96 participants

Inactivated Influenza A/H9N2 Vaccine With and Without MF59 Adjuvant in Ambulatory Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00133471

COMPLETED Phase 4 90 participants

Collection of Serum Samples From Children and Older Adults Receiving the 2019-2020 Formulations of Fluzone® Quadrivalent and Fluzone® High-Dose Influenza Vaccines, Respectively

Sanofi Pasteur, a Sanofi Company

NCT04109222

COMPLETED 87 participants

Sanofi Pasteur Quadrivalent Intradermal Influenza Vaccine Pregnancy Registry

Sanofi Pasteur, a Sanofi Company

NCT02554409

COMPLETED Phase 1 87 participants

Oseltamivir Treatment for Children Less Than 24 Months of Age With Influenza

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00391768

COMPLETED Phase 4 86 participants

Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014)

Stanford University

NCT02141581

COMPLETED Phase 2 82 participants

Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03845231

COMPLETED Phase 1 80 participants

The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection

Stanford University

NCT03453801

COMPLETED Phase 4 72 participants

T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009

Stanford University

NCT01987349

COMPLETED Phase 1 68 participants

Safety, Tolerability, and PK of Escalating Doses of Flufirvitide-3 Dry Powder for Inhalation in Healthy Subjects

Autoimmune Technologies

NCT01990846

COMPLETED Phase 4 60 participants

Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent Influenza Virus Vaccine

Sanofi Pasteur, a Sanofi Company

NCT01946425

COMPLETED Phase 4 60 participants

Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent, Influenza Vaccine

Sanofi Pasteur, a Sanofi Company

NCT02222870

COMPLETED Phase 2 60 participants

Single-ascending-dose Study of the Safety and Immunogenicity of NasoVAX

Altimmune

NCT03232567

COMPLETED 60 participants

Elderly Influenza Vaccine Immunogenicity Substudy

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00170482

COMPLETED NA 58 participants

Evaluation of Free Air Portable Air Powered Respirator

Wake Forest University Health Sciences

NCT02487147

COMPLETED Phase 1 56 participants

Phase 1 Safety and Immunogenicity Study in Healthy Adults of VAX125, a Recombinant HA-flagellin Influenza Vaccine

VaxInnate Corporation

NCT00730457

COMPLETED Phase 2 52 participants

Study to Evaluate the Immune Responses of Trivalent Cold-Adapted Influenza Vaccine (CAIV-T) Compared With (TIV)

MedImmune

NCT00111579

COMPLETED Phase 1 51 participants

Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing In Gammopathy Patients

Yale University

NCT02267733

COMPLETED Phase 4 51 participants

B-cell Immunity to Influenza (SLVP017)- Year 1, 2009

Stanford University

NCT02133781

COMPLETED Phase 3 50 participants

Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure

GlaxoSmithKline

NCT01788228

COMPLETED Phase 1 49 participants

Influenza A 2009 H1N1 Challenge Study in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01646138

COMPLETED Phase 1 43 participants

Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01578317

COMPLETED Phase 1 41 participants

A Study of VIS410 to Assess Safety and Pharmacokinetics

Visterra

NCT02045472

COMPLETED Phase 4 34 participants

Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children

University of Rochester

NCT01246999

COMPLETED Phase 4 34 participants

Phase IV Trial to Collect Safety Data and Sera for Immunogenicity Testing in Healthy Children Given Fluzone® Vaccine

Sanofi Pasteur, a Sanofi Company

NCT00561002

COMPLETED Phase 2 31 participants

Phase II Study to Investigate the Kinetics of the Immune Response Generated by Influenza Virus Vaccine.

MedImmune

NCT00192309

COMPLETED Phase 1 31 participants

Anti-Influenza Hyperimmune Intravenous Immunoglobulin Pilot Study (INSIGHT 005: Flu-IVIG Pilot)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT02008578

COMPLETED Phase 1 30 participants

Safety of and Immune Response to a Bird Flu Virus Vaccine (H9N2) in Healthy Adults (Study A)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00110279

COMPLETED Phase 1 30 participants

Safety of Lactobacillus Rhamnosus GG Versus Placebo in Elderly Subjects Receiving Live Attenuated Influenza Vaccine

Patricia L. Hibberd

NCT01545349

COMPLETED Phase 2 27 participants

H7N9 Boost in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT02586792

COMPLETED Phase 1 27 participants

Safety, Tolerability, and Pharmacokinetics of SAB-176 in Healthy Participants

SAb Biotherapeutics

NCT04471038

COMPLETED Phase 1 22 participants

Safety and Immune Response to Recombinant Live-Attenuated Influenza H2N2 Virus Vaccine

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00722774

COMPLETED Phase 1 22 participants

Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly

Mayo Clinic

NCT01304771

COMPLETED Phase 1 22 participants

Safety of and Immune Response to Recombinant Live-Attenuated Influenza H6N1 Virus Vaccine Vaccine

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00734175

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 31
Phase 3 17
Phase 4 25

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Influenza Trial Landscape

157 indexed Influenza studies · 27 recruiting (17%).

Phase mix: 42 late (III/IV) vs 73 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (36 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Influenza?

PlainTrial tracks 157 US clinical trials for Influenza, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Influenza?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.