Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Hypercapnia: early-phase trial registry
2 of 6 indexed Hypercapnia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 2 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Hypercapnia: 6 US clinical trials tracked, 2 recruiting.
Hypercapnia is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Vapotherm, running 1 of these trials.
Enrollment posture brief
Registry condition hypercapnia
OPEN 2 | RECR 33% | LATE 0 | EARLY 1 | RANK #2866 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)
Hypercapnia lists 2 open slots (33% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hypercapnia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hypercapnia is recruiting below its size-band peers.
2 of 6 indexed trials (33.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Hypercapnia research.
Vapotherm accounts for 1 of 6 trials (16.7%). 6 distinct sponsors appear on at least one study for this condition label.
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Most Hypercapnia trials plan to enrol fewer than 100 people.
Median target enrolment is 55 among the 6 trials that report a genuine target (sentinel values excluded). 6 of those (100%) plan for fewer than 100 participants.
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Hypercapnia research is mostly interventional.
5 interventional and 1 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Oxygen Toxicity: Mechanisms in Humans
Duke University
NCT05761756
Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury
VA Office of Research and Development
NCT05536076
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
University of Wisconsin, Madison
NCT01317329
Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
Food and Drug Administration (FDA)
NCT04310579
Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
National Institutes of Health Clinical Center (CC)
NCT00001845
Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs
Vapotherm
NCT04512781
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Hypercapnia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hypercapnia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hypercapnia page
6 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Hypercapnia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vapotherm sponsors the most Hypercapnia trials on record, review their full trial history before evaluating a specific study. See Vapotherm's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hypercapnia condition card totals 6 registered trials; most-linked intervention Control Cannula - Unicorn Cannula - Prosoft Cannula; top US site state Wisconsin. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.