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NCT05761756 · ClinicalTrials.gov registry record · NA
Oxygen Toxicity: Mechanisms in Humans
A NA study of Seizures and Hypercapnia, sponsored by Duke University.
- Recruiting
- Registry status
- NA
- Development phase
- 62
- Enrollment target
- 1
- Study location
NCT05761756: Recruiting NA study of Seizures and Hypercapnia, sponsored by Duke University.
NCT05761756 is a NA study of Seizures and Hypercapnia that is actively recruiting participants, run by Duke University. The registered enrollment target is 62 participants, below the 933-participant average among 39 other Seizures trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05761756, a NA study of Seizures and Hypercapnia, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- NA
- Development phase
- 62 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? * How does immersion in water affect the development of oxygen toxicity? Participants will be asked to do the following: * Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests * Train their respiratory muscles at regular intervals * Exercise on a cycle ergometer both in dry conditions and underwater/under pressure in the context of medication, sleep deprivation, or carbon dioxide exposure Researchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.
Conditions Studied
Interventions
- DRUG Methylphenidate
- BEHAVIORAL Sleep Deprivation
- DRUG Caffeine
- DRUG Carbon Dioxide
Study Locations (1)
North Carolina
- Duke University Health Sustem - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2023-11-28 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
What NCT05761756 shows while recruiting
NCT05761756 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 933-participant average among 39 other Seizures trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Seizures appearing as the primary indexed condition, and to 4 interventions - of which Methylphenidate is the first listed.
NCT05761756 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05761756 about?
NCT05761756 is a clinical study titled "Oxygen Toxicity: Mechanisms in Humans". The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly ...
What is the current status of trial NCT05761756?
This trial is currently recruiting. It is a NA study. The enrollment target is 62 participants. The study started on 2023-11-28. Estimated completion is 2026-08-31.
What conditions does trial NCT05761756 study?
This clinical trial studies the following conditions: Seizures, Hypercapnia, Oxygen Toxicity.
What interventions are being tested in trial NCT05761756?
The interventions under investigation include: Methylphenidate (DRUG), Sleep Deprivation (BEHAVIORAL), Caffeine (DRUG), Carbon Dioxide (DRUG).
Who is sponsoring clinical trial NCT05761756?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05761756 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05761756's enrollment target sits among peer trials
62 21st of 39 higher than 19 of 39 other Seizures trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Seizures trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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