Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06872307 · ClinicalTrials.gov registry record · NA
Intervention to Enhance PrEP Persistence
A NA study of HIV Prevention and HIV Infection Primary, sponsored by Brown University.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 3
- Study locations
NCT06872307: Recruiting NA study of HIV Prevention and HIV Infection Primary, sponsored by Brown University.
NCT06872307 is a NA study of HIV Prevention and HIV Infection Primary that is actively recruiting participants, run by Brown University. The registered enrollment target is 300 participants, below the 372-participant average among 32 other HIV Prevention trials with a reported enrollment target (19% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06872307, a NA study of HIV Prevention and HIV Infection Primary, is actively recruiting participants, sponsored by Brown University.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 3
- Study locations
Study Summary
The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention for Black/African American (B/AA) men who have sex with men (MSM) on PrEP initiation, adherence and retention in care. B/AA men who have sex with men (MSM) are disproportionately impacted by the HIV/AIDS epidemic in the United States. Pre-exposure prophylaxis (PrEP), a once daily medication, can dramatically reduce HIV acquisition risk. However, social and structural barriers have contributed to suboptimal PrEP initiation, adherence, and retention in care among B/AA MSM. Our prior NIH-funded pilot study (R34MH109371; MPI: Nunn, Chan, Mena) developed and evaluated an Intervention to Retain and Adhere MSM in PrEP (RAMP-IT-UP), a brief strengths-based patient navigation program to enhance PrEP care outcomes among young B/AA MSM. The intervention was found to be highly acceptable among B/AA MSM and demonstrated preliminary effectiveness. Compared to control participants, RAMP-IT-UP participants were statistically more likely to initiate PrEP and adhere to PrEP based on pharmacy fill data and PrEP blood levels. Additionally, RAMP-IT-UP participants were more likely to be retained in PrEP care at the 3-month and 6-month clinical visits. Specific Aim #1 of this study will conduct a fully powered randomized controlled trial (RCT to estimate the effectiveness of RAMP-IT-UP in improving PrEP adherence and care outcomes among B/AA MSM in real-world community health center settings (CHCs). Specific Aim #2 will estimate the cost-effectiveness of RAMP-IT-UP among B/AA MSM attending CHCs compared to standard of care. The investigators will also determine the cost-effectiveness of differing levels of intensity of navigation services to prevent HIV based on data collected in Specific Aim #1. Our goal is to develop a cost-effective intervention that enhances PrEP care outcomes and reduces HIV incidence for B/AA MSM which will be relevant for CHCs ac
Primary Outcome
The primary outcome will be PrEP adherence, given adherence is the definitive marker associated with protection from HIV infection. Adherence will be measured using pharmacy fill data in order to determine whether participants have picked up their prescription on a monthly basis.
Conditions Studied
Interventions
- BEHAVIORAL RAMP-It-Up Initiation, Adherence, and Retention Intervention
Study Locations (3)
District of Columbia
- Whitman Walker Health - Washington D.C.
Mississippi
- University of Mississippi Medical Center - Jackson
Rhode Island
- The Rhode Island Public Health Institute - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2024-10-01 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
What NCT06872307 shows while recruiting
NCT06872307 is an interventional study that assigns participants to a tested intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 372-participant average among 32 other HIV Prevention trials with a reported enrollment target (19% lower).
The record links to 2 conditions, with HIV Prevention appearing as the primary indexed condition, and to 1 intervention - of which RAMP-It-Up Initiation, Adherence, and Retention Intervention is the first listed.
NCT06872307 reports a single indexed study location in District of Columbia, Mississippi, Rhode Island.
Frequently Asked Questions
What is clinical trial NCT06872307 about?
NCT06872307 is a clinical study titled "Intervention to Enhance PrEP Persistence". The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention for Black/African American (B/AA) men who have sex with men (MSM) on PrEP initiation, adherence and retention in care. B/AA men who have sex with men (MSM) are dis...
What is the current status of trial NCT06872307?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2024-10-01. Estimated completion is 2028-07-31.
What conditions does trial NCT06872307 study?
This clinical trial studies the following conditions: HIV Prevention, HIV Infection Primary.
What interventions are being tested in trial NCT06872307?
The interventions under investigation include: RAMP-It-Up Initiation, Adherence, and Retention Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT06872307?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06872307 being conducted?
This trial has 3 study locations across District of Columbia, Mississippi, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV Prevention
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06872307's enrollment target sits among peer trials
300 10th of 32 higher than 22 of 32 other HIV Prevention trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Prevention trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Using PrEP, Doing It for Ourselves
RECRUITING · NA
-
Client-Centered Care Coordination for Black Men Who Have Sex With Men
RECRUITING · NA
-
Behavioral Economic Intervention to Improve HIV Behaviors in Sexual Minority Individuals
RECRUITING · NA
-
WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women
RECRUITING · NA
-
Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
RECRUITING · NA
-
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00353483 · 300 participants
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells
- NCT00588185 · 300 participants · NA
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer
- NCT00682032 · 300 participants · NA
The Effect of Beta-glucan in Non-Small Cell Lung Cancer
- NCT00870064 · 300 participants · NA
The Treatment of Type I Open Fractures in Pediatrics
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI