Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Metastatic Breast Carcinoma

Open-data reference.

33 US clinical trials · 20 currently recruiting

Active & Recent Trials

RECRUITING 2,000 participants

Collection of Specimens and Clinical Data for Patients With Recurrent or Metastatic Breast Cancer or Male Breast Cancer

Mayo Clinic

NCT06217874

RECRUITING 700 participants

Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors

Roswell Park Cancer Institute

NCT04526587

RECRUITING Phase 2 332 participants

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

National Cancer Institute (NCI)

NCT01174121

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING Phase 3 115 participants

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

NRG Oncology

NCT06500481

RECRUITING Phase 2 75 participants

Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial

University of Michigan Rogel Cancer Center

NCT07158021

RECRUITING Phase 2 60 participants

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

M.D. Anderson Cancer Center

NCT04090567

RECRUITING 50 participants

Living Well With Advanced Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT07227038

RECRUITING Phase 1 45 participants

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

National Cancer Institute (NCI)

NCT05372640

RECRUITING Phase 2 43 participants

Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

City of Hope Medical Center

NCT04305834

RECRUITING Phase 2 40 participants

A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT05534438

RECRUITING Phase 1 36 participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

National Cancer Institute (NCI)

NCT07137416

RECRUITING Phase 2 35 participants

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

City of Hope Medical Center

NCT06910761

RECRUITING 30 participants

A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06557148

RECRUITING Phase 2 22 participants

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

University of Washington

NCT06518057

RECRUITING Phase 1 22 participants

[18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer

University of Washington

NCT06502691

RECRUITING Phase 2 18 participants

Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

City of Hope Medical Center

NCT06260033

RECRUITING Phase 2 11 participants

Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

City of Hope Medical Center

NCT06860815

RECRUITING Phase 4 10 participants

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

City of Hope Medical Center

NCT05376878

RECRUITING NA 5 participants

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Mayo Clinic

NCT05746325

ACTIVE NOT RECRUITING Phase 3 608 participants

Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

National Cancer Institute (NCI)

NCT02115282

ACTIVE NOT RECRUITING NA 243 participants

A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer

Ohio State University Comprehensive Cancer Center

NCT05215769

ACTIVE NOT RECRUITING Phase 2 138 participants

Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study

ECOG-ACRIN Cancer Research Group

NCT04316117

ACTIVE NOT RECRUITING Phase 2 81 participants

Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer

National Cancer Institute (NCI)

NCT02849496

ACTIVE NOT RECRUITING 68 participants

Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy

Mayo Clinic

NCT03281902

ACTIVE NOT RECRUITING Phase 2 47 participants

Pembrolizumab, Endocrine Therapy, and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer

City of Hope Medical Center

NCT02778685

ACTIVE NOT RECRUITING Phase 2 40 participants

Nab-Paclitaxel in Treating Older Patients With Locally Advanced or Metastatic Breast Cancer

City of Hope Medical Center

NCT01463072

ACTIVE NOT RECRUITING Phase 1 35 participants

Cyclophosphamide and Veliparib in Treating Patients With Locally Advanced or Metastatic Breast Cancer

National Cancer Institute (NCI)

NCT01351909

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

National Cancer Institute (NCI)

NCT03939897

ACTIVE NOT RECRUITING Phase 1 23 participants

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT03218826

ACTIVE NOT RECRUITING Phase 1 18 participants

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

University of Washington

NCT04673448

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

COMPLETED Phase 1 18 participants

Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer

M.D. Anderson Cancer Center

NCT03207529

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 13
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Breast Carcinoma Trial Landscape

ClinicalTrials.gov lists 33 US studies indexed under Metastatic Breast Carcinoma, and 20 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Breast Carcinoma shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Breast Carcinoma is led by National Cancer Institute (NCI) with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 33 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Breast Carcinoma?

PlainTrial tracks 33 US clinical trials for Metastatic Breast Carcinoma, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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