Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Heart Failure With Normal Ejection Fraction: early-phase trial registry
4 of 11 indexed Heart Failure With Normal Ejection Fraction trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,577 of 28,707 conditions by registered trial count.
11 US clinical trials · 4 currently recruiting · #1,577 of 28,707 conditions by registered trial count
Heart Failure With Normal Ejection Fraction: 11 US clinical trials tracked, 4 recruiting.
Heart Failure With Normal Ejection Fraction is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 3 of these trials.
Enrollment posture brief
Registry condition heart-failure-with-normal-ejection-fraction
OPEN 4 | RECR 36% | LATE 0 | EARLY 3 | RANK #1577 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive (36% recruiting · 11 trials)
Heart Failure With Normal Ejection Fraction lists 4 open slots (36% of 11 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure With Normal Ejection Fraction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Heart Failure With Normal Ejection Fraction is recruiting below its size-band peers.
4 of 11 indexed trials (36.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
One sponsor concentrates Heart Failure With Normal Ejection Fraction research.
Massachusetts General Hospital accounts for 3 of 11 trials (27.3%). 9 distinct sponsors appear on at least one study for this condition label.
-
Typical Heart Failure With Normal Ejection Fraction enrolment sits around 96 participants.
Median target enrolment is 96 among the 11 trials that report a genuine target (sentinel values excluded). 6 of those (54.5%) plan for fewer than 100 participants.
-
Heart Failure With Normal Ejection Fraction splits between interventional and observational designs.
7 interventional and 4 observational studies make up this index (63.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
11 total, page 1 of 1
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Massachusetts General Hospital
NCT03480633
New Orleans Pulmonary Hypertension Biobank
Louisiana State University Health Sciences Center in New Orleans
NCT03269630
Exercise Intolerance in Heart Failure
Johns Hopkins University
NCT03775577
Imaging Histone Deacetylase in the Heart
Massachusetts General Hospital
NCT03549559
Circulating RNAs in Acute Congestive Heart Failure
Massachusetts General Hospital
NCT03345446
Ablation Versus Medical Management of Atrial Fibrillation in HFpEF
Inova Health Care Services
NCT04282850
Hemodynamic-GUIDEd Management of Heart Failure
Abbott Medical Devices
NCT03387813
Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction
University of Oklahoma
NCT03327649
Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients
Tenax Therapeutics
NCT03624010
Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity
Corporal Michael J. Crescenz VA Medical Center
NCT01919177
Treatment of HFpEF With Nitrate Supplement
MaineHealth
NCT03289481
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure With Normal Ejection Fraction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure With Normal Ejection Fraction trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure With Normal Ejection Fraction page
11 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Heart Failure With Normal Ejection Fraction trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Heart Failure With Normal Ejection Fraction trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure With Normal Ejection Fraction condition card totals 11 registered trials; most-linked intervention Levosimendan 2.5 mg/ml Injectable Solution; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.