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Gastroesophageal Reflux Disease clinical trials
3 of 25 indexed Gastroesophageal Reflux Disease trials are currently recruiting.
25 US clinical trials · 3 currently recruiting
Gastroesophageal Reflux Disease is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 3 of these trials.
The research picture
Gastroesophageal Reflux Disease has 25 registered US clinical trials, 3 of them open to new participants right now, about 12% of the total.
- 3
- recruiting participants now
- 12%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Takeda
Active & Recent Trials
25 total, page 1 of 1
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
Midwest Biomedical Research Foundation
NCT00574327
Domperidone in Treating Patients With Gastrointestinal Disorders
M.D. Anderson Cancer Center
NCT01696734
Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)
University of California, Irvine
NCT06783751
Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
University of Pittsburgh
NCT00260572
Transoral Fundoplication Prior to Sleeve Gastrectomy Versus RNY Gastric Bypass on GERD Symptoms in Bariatric Patients
Lexington Health Incorporated
NCT05365087
Morphological Markers of Gastroesophageal Reflux Disease (GERD)
Baylor College of Medicine
NCT01921686
GCC Agonist Signal in the Small Intestine
University of Wisconsin, Madison
NCT05107219
Economic Impact of Guidelines for Gastroesophageal Reflux Disease
US Department of Veterans Affairs
NCT00057174
Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD)
Shire
NCT01472939
A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)
Ironwood Pharmaceuticals
NCT02637557
Maintenance Intermittent Therapy for Symptomatic GERD Patients
Eisai
NCT00165841
Randomized EsophyX Versus Sham / Placebo Controlled TIF Trial: The RESPECT Study
EndoGastric Solutions
NCT01136980
Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures
Swedish Medical Center
NCT01260935
Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole
Eisai
NCT00132496
Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents
Takeda
NCT01642602
Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.
Associated Scientists to Help Minimize Allergies
NCT00214552
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
University of Nebraska
NCT01776827
Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents
Takeda
NCT01642615
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Mayo Clinic
NCT00728481
Esophageal Cytology With FISH in Detecting Esophageal Cancer
OHSU Knight Cancer Institute
NCT02100189
Pharmacodynamic and Pharmacokinetic Study of E3710 Following Oral Administration to Healthy, Male, Japanese Subjects
Eisai Co.
NCT01390714
Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?
University of North Carolina, Chapel Hill
NCT02226484
Gastric Bypass After Previous Anti-reflux Surgery
University of California, San Francisco
NCT01041105
Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease
OHSU Knight Cancer Institute
NCT02890979
Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets
Takeda
NCT02096458
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 7 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Gastroesophageal Reflux Disease Trial Landscape
25 indexed Gastroesophageal Reflux Disease studies · 3 recruiting (12%).
Phase mix: 2 late (III/IV) vs 11 early (I/II).
Top sponsor: Takeda (3 trials), 9 others listed. 25 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Gastroesophageal Reflux Disease?
PlainTrial tracks 25 US clinical trials for Gastroesophageal Reflux Disease, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Gastroesophageal Reflux Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.