Ironwood Pharmaceuticals

23 total trials 20 completed

Ironwood Pharmaceuticals sponsors 23 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 20 completed. 8 of these trials are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Chronic Constipation, with 1 trials.

Trial Pipeline

23 total, page 1 of 1

TERMINATED Phase 2

A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome

NCT05740007

COMPLETED Phase 1

A Study of Multiple-ascending Doses of IW-3300 in Healthy Subjects

NCT05362695

COMPLETED Phase 1

A Study of Single Ascending Doses of IW-3300 in Healthy Volunteers

NCT05188261

COMPLETED Phase 2

A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome

NCT03931785

COMPLETED Phase 1

Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

NCT03856970

COMPLETED Phase 3

Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

NCT03561883

COMPLETED Phase 3

A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

NCT03573908

TERMINATED Phase 3

A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

NCT03561090

TERMINATED Phase 4

A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment

NCT03226899

COMPLETED Phase 2

A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)

NCT02637557

COMPLETED Phase 2

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

NCT02559206

COMPLETED Phase 2

Trial of IW-9179 in Patients With Diabetic Gastroparesis (DGP)

NCT02289846

COMPLETED Phase 3

Trial of Linaclotide in Patients With Chronic Idiopathic Constipation

NCT02291679

COMPLETED Phase 2

Ph2a Study to Evaluate IW-3718 in Patients With Gastroesophageal Reflux Not Completely Responsive to Proton Pump Inhibitors

NCT02030925

COMPLETED Phase 2

Study to Evaluate Efficacy and Safety of IW-6118 in Patients Undergoing Third Molar Extraction

NCT01107236

COMPLETED Phase 3

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

NCT00938717

COMPLETED Phase 3

An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation

NCT00730171

COMPLETED Phase 3

Trial of Linaclotide in Patients With Chronic Constipation

NCT00730015

COMPLETED Phase 2

Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

NCT00460811

COMPLETED Phase 2

Study of Oral MD-0727 Administered to Patients With Primary Hypercholesterolemia

NCT00404001

COMPLETED Phase 2

Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation

NCT00402337

COMPLETED Phase 2

Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation

NCT00306748

COMPLETED Phase 2

Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS

NCT00258193

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 7
Phase 4 1

What the Pipeline for Ironwood Pharmaceuticals Shows

According to the ClinicalTrials.gov registry, Ironwood Pharmaceuticals is linked to 23 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 20 are already marked complete, representing roughly 87% of the total.

The phase mix for Ironwood Pharmaceuticals reports 8 late-stage studies (Phase 3 and Phase 4 combined) and 15 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Ironwood Pharmaceuticals is Chronic Constipation with 1 linked trial, and 4 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.