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ClinicalTrials.gov 8 recruiting now official registry

GastroEsophageal Cancer clinical trials

8 of 24 indexed GastroEsophageal Cancer trials are currently recruiting.

24 US clinical trials · 8 currently recruiting

GastroEsophageal Cancer is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 3 of these trials.

The research picture

GastroEsophageal Cancer has 24 registered US clinical trials, 8 of them open to new participants right now, about 33% of the total.

8
recruiting participants now
33%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Phase 19Phase 27Phase 31

Active & Recent Trials

24 total, page 1 of 1

RECRUITING 9,600 participants

Sample Collection for Ongoing Research and Product Evaluation Study

Natera

NCT07318051

RECRUITING Phase 2 200 participants

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Jazz Pharmaceuticals

NCT06695845

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING NA 80 participants

Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06497569

RECRUITING Phase 2 58 participants

Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma

Harry H Yoon

NCT04069273

RECRUITING Phase 2 50 participants

PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer

Medical College of Wisconsin

NCT06906887

RECRUITING Phase 2 36 participants

Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06109467

RECRUITING 20 participants

Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers

M.D. Anderson Cancer Center

NCT05205343

ACTIVE NOT RECRUITING Phase 3 450 participants

A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)

Merck Sharp & Dohme

NCT06356311

ACTIVE NOT RECRUITING NA 300 participants

Supportive Oncology Care At Home RCT

Massachusetts General Hospital

NCT04544046

ACTIVE NOT RECRUITING Phase 2 34 participants

Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma

University of California, Irvine

NCT04164979

ACTIVE NOT RECRUITING Phase 1 32 participants

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03044613

ACTIVE NOT RECRUITING 28 participants

Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radiation Therapy

Ohio State University Comprehensive Cancer Center

NCT05717998

ACTIVE NOT RECRUITING NA 23 participants

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Gastroesophageal Cancer (GEC) Patients

H. Lee Moffitt Cancer Center and Research Institute

NCT05438940

ACTIVE NOT RECRUITING Phase 1 21 participants

REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03610711

ACTIVE NOT RECRUITING Phase 2 9 participants

Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers

University of Colorado, Denver

NCT05379972

ACTIVE NOT RECRUITING 4 participants

A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers

Memorial Sloan Kettering Cancer Center

NCT06243757

COMPLETED Phase 1 151 participants

A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab

Leap Therapeutics

NCT02013154

COMPLETED Phase 1 49 participants

Phase I/II Trial of Tivantinib With FOLFOX for the Treatment of Advanced Solid Tumors and Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction or Stomach

SCRI Development Innovations

NCT01611857

COMPLETED Phase 1 48 participants

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Arcus Biosciences

NCT03629756

COMPLETED Phase 2 39 participants

FOLFOX With Bevacizumab in Metastatic or Unresectable Gastroesophageal and Gastric Cancer

Yale University

NCT00673673

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED Phase 1 25 participants

A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers

Massachusetts General Hospital

NCT03279237

COMPLETED Phase 1 22 participants

Avelumab With Chemoradiation for Stage II/III Resectable Esophageal and Gastroesophageal Cancer

University of Wisconsin, Madison

NCT03490292

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the GastroEsophageal Cancer Trial Landscape

24 indexed GastroEsophageal Cancer studies · 8 recruiting (33%).

Phase mix: 1 late (III/IV) vs 16 early (I/II).

Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (3 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for GastroEsophageal Cancer?

PlainTrial tracks 24 US clinical trials for GastroEsophageal Cancer, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for GastroEsophageal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.