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ClinicalTrials.gov 6 recruiting now official registry

GastroEsophageal Cancer clinical trials

Every US clinical trial registered for GastroEsophageal Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

17 US clinical trials · 6 currently recruiting

The research picture

GastroEsophageal Cancer has 17 registered US clinical trials, 6 of them open to new participants right now — about 35% of the total.

6
recruiting participants now
35%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: H. Lee Moffitt Cancer Center and Research Institute

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING NA 80 participants

Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06497569

RECRUITING Phase 2 58 participants

Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma

Harry H Yoon

NCT04069273

RECRUITING Phase 2 50 participants

PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer

Medical College of Wisconsin

NCT06906887

RECRUITING Phase 2 36 participants

Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06109467

RECRUITING 20 participants

Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers

M.D. Anderson Cancer Center

NCT05205343

ACTIVE NOT RECRUITING NA 300 participants

Supportive Oncology Care At Home RCT

Massachusetts General Hospital

NCT04544046

ACTIVE NOT RECRUITING Phase 2 34 participants

Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma

University of California, Irvine

NCT04164979

ACTIVE NOT RECRUITING Phase 1 32 participants

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03044613

ACTIVE NOT RECRUITING 28 participants

Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radiation Therapy

Ohio State University Comprehensive Cancer Center

NCT05717998

ACTIVE NOT RECRUITING NA 23 participants

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Gastroesophageal Cancer (GEC) Patients

H. Lee Moffitt Cancer Center and Research Institute

NCT05438940

ACTIVE NOT RECRUITING Phase 2 9 participants

Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers

University of Colorado, Denver

NCT05379972

ACTIVE NOT RECRUITING 4 participants

A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers

Memorial Sloan Kettering Cancer Center

NCT06243757

COMPLETED Phase 1 48 participants

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Arcus Biosciences

NCT03629756

COMPLETED Phase 1 38 participants

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Tempest Therapeutics

NCT03829436

COMPLETED Phase 1 25 participants

A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers

Massachusetts General Hospital

NCT03279237

COMPLETED Phase 1 22 participants

Avelumab With Chemoradiation for Stage II/III Resectable Esophageal and Gastroesophageal Cancer

University of Wisconsin, Madison

NCT03490292

Reading the GastroEsophageal Cancer Trial Landscape

ClinicalTrials.gov lists 17 US studies indexed under GastroEsophageal Cancer, and 6 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for GastroEsophageal Cancer shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 11 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for GastroEsophageal Cancer is led by H. Lee Moffitt Cancer Center and Research Institute with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for GastroEsophageal Cancer?

PlainTrial tracks 17 US clinical trials for GastroEsophageal Cancer, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for GastroEsophageal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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