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NCT06906887 · ClinicalTrials.gov registry record · Phase 2
PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer
A Phase 2 study of Esophageal Cancer and GastroEsophageal Cancer, sponsored by Medical College of Wisconsin.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06906887: Recruiting Phase 2 study of Esophageal Cancer and GastroEsophageal Cancer, sponsored by Medical College of Wisconsin.
NCT06906887 is a Phase 2 study of Esophageal Cancer and GastroEsophageal Cancer that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 50 participants, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06906887, a Phase 2 study of Esophageal Cancer and GastroEsophageal Cancer, is actively recruiting participants, sponsored by Medical College of Wisconsin.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective, randomized, open-label, two-arm phase 2 trial that will evaluate whether the use of Pulsed Low-Dose-Rate radiation technique, as compared to standard radiation, is associated with reduced rates of clinically significant esophagitis during and following chemoradiation.
Primary Outcome
The number of subjects requiring a new prescription for narcotics.
Conditions Studied
Interventions
- DRUG Chemotherapy
- PROCEDURE Surgery
- DRUG Induction Chemotherapy (modified FLOT or modified FOLFOX-6)
- RADIATION Conventional Radiation
- RADIATION Pulsed Low-Dose-Rate (PLDR) Radiation
Study Locations (1)
Wisconsin
- Froedtert & the Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-06-17 |
| Est. Completion | 2032-06-01 |
| Phase | Phase 2 |
What NCT06906887 shows while recruiting
NCT06906887 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Esophageal Cancer appearing as the primary indexed condition, and to 5 interventions - of which Chemotherapy is the first listed.
NCT06906887 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT06906887 about?
NCT06906887 is a clinical study titled "PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer". This is a prospective, randomized, open-label, two-arm phase 2 trial that will evaluate whether the use of Pulsed Low-Dose-Rate radiation technique, as compared to standard radiation, is associated with reduced rates of clinically significant esophagitis during and following chemoradiation.
What is the current status of trial NCT06906887?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2025-06-17. Estimated completion is 2032-06-01.
What conditions does trial NCT06906887 study?
This clinical trial studies the following conditions: Esophageal Cancer, GastroEsophageal Cancer, Oesophageal Cancer.
What interventions are being tested in trial NCT06906887?
The interventions under investigation include: Chemotherapy (DRUG), Surgery (PROCEDURE), Induction Chemotherapy (modified FLOT or modified FOLFOX-6) (DRUG), Conventional Radiation (RADIATION), Pulsed Low-Dose-Rate (PLDR) Radiation (RADIATION).
Who is sponsoring clinical trial NCT06906887?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06906887 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Esophageal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06906887's enrollment target sits among peer trials
50 75th of 123 higher than 47 of 123 other Esophageal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Esophageal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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