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ClinicalTrials.gov 9 recruiting now official registry

Extensive Stage Lung Small Cell Carcinoma clinical trials

9 of 17 indexed Extensive Stage Lung Small Cell Carcinoma trials are currently recruiting.

17 US clinical trials · 9 currently recruiting

Extensive Stage Lung Small Cell Carcinoma is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 7 of these trials.

The research picture

Extensive Stage Lung Small Cell Carcinoma has 17 registered US clinical trials, 9 of them open to new participants right now, about 53% of the total.

9
recruiting participants now
53%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
7
top sponsor: National Cancer Institute (NCI)
Phase 18Phase 28Phase 31

Active & Recent Trials

17 total, page 1 of 1

RECRUITING Phase 2 900 participants

Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

SWOG Cancer Research Network

NCT06769126

RECRUITING Phase 3 668 participants

S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

SWOG Cancer Research Network

NCT04155034

RECRUITING Phase 2 138 participants

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

National Cancer Institute (NCI)

NCT04402788

RECRUITING Phase 2 56 participants

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

Dwight Owen

NCT04919382

RECRUITING Phase 1 45 participants

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT06287775

RECRUITING Phase 2 39 participants

Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer

Asrar Alahmadi

NCT07423585

RECRUITING Phase 2 28 participants

Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer

Roswell Park Cancer Institute

NCT04696575

RECRUITING Phase 1 22 participants

Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer

Emory University

NCT05244239

RECRUITING Phase 1 18 participants

Phase I/II Trial in ES-SCLC to Enhance Response to Atezolizumab Plus Chemotherapy With Total Body Irradiation

Vanderbilt-Ingram Cancer Center

NCT06110572

ACTIVE NOT RECRUITING Phase 2 104 participants

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

National Cancer Institute (NCI)

NCT03896503

ACTIVE NOT RECRUITING Phase 2 103 participants

Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker

National Cancer Institute (NCI)

NCT04334941

ACTIVE NOT RECRUITING Phase 1 63 participants

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

M.D. Anderson Cancer Center

NCT04728230

ACTIVE NOT RECRUITING Phase 1 59 participants

Niraparib, Temozolomide and Atezolizumab in Treating Patients With Advanced Solid Tumors and Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy

Jonsson Comprehensive Cancer Center

NCT03830918

ACTIVE NOT RECRUITING Phase 1 18 participants

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT05353439

ACTIVE NOT RECRUITING Phase 1 3 participants

LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer

City of Hope Medical Center

NCT04560972

COMPLETED Phase 2 160 participants

Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03382561

COMPLETED Phase 1 3 participants

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

National Cancer Institute (NCI)

NCT04631029

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 8
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Extensive Stage Lung Small Cell Carcinoma Trial Landscape

17 indexed Extensive Stage Lung Small Cell Carcinoma studies · 9 recruiting (53%).

Phase mix: 1 late (III/IV) vs 16 early (I/II).

Top sponsor: National Cancer Institute (NCI) (7 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Extensive Stage Lung Small Cell Carcinoma?

PlainTrial tracks 17 US clinical trials for Extensive Stage Lung Small Cell Carcinoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Extensive Stage Lung Small Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.