Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04155034 · ClinicalTrials.gov registry record · Phase 3
S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
A Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma, sponsored by SWOG Cancer Research Network.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 668
- Enrollment target
- 20
- Study locations
NCT04155034 is a Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma that is actively recruiting participants, run by SWOG Cancer Research Network. The registered enrollment target is 668 participants, above the 110-participant average among 16 other Extensive Stage Lung Small Cell Carcinoma trials with a reported enrollment target (507% higher). The trial reports 20 study locations across 5 states.
The verdict
NCT04155034, a Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma, is actively recruiting participants, sponsored by SWOG Cancer Research Network.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 668 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.
Conditions Studied
Interventions
- PROCEDURE Magnetic Resonance Imaging
- RADIATION Prophylactic Cranial Irradiation
Study Locations (20)
California
- City of Hope Corona - Corona
- City of Hope Comprehensive Cancer Center - Duarte
- Veterans Affairs Loma Linda Healthcare System - Loma Linda
- Tibor Rubin VA Medical Center - Long Beach
- Los Angeles General Medical Center - Los Angeles
- USC / Norris Comprehensive Cancer Center - Los Angeles
- University of California Davis Comprehensive Cancer Center - Sacramento
- Veterans Affairs Medical Center - San Francisco - San Francisco
- City of Hope South Pasadena - South Pasadena
Colorado
- Rocky Mountain Regional VA Medical Center - Aurora
- UCHealth University of Colorado Hospital - Aurora
- UCHealth Memorial Hospital Central - Colorado Springs
- Memorial Hospital North - Colorado Springs
- Poudre Valley Hospital - Fort Collins
- Cancer Care and Hematology-Fort Collins - Fort Collins
Alaska
- Katmai Oncology Group - Anchorage
- Fairbanks Memorial Hospital - Fairbanks
Arizona
- University of Arizona Cancer Center-Orange Grove Campus - Tucson
- University of Arizona Cancer Center-North Campus - Tucson
Alabama
- University of Alabama at Birmingham Cancer Center - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 668 participants |
| Start Date | 2020-05-04 |
| Est. Completion | 2029-11-15 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04155034
The ClinicalTrials.gov registry entry for NCT04155034 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 668 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 110-participant average among 16 other Extensive Stage Lung Small Cell Carcinoma trials with a reported enrollment target (507% higher). The listed sponsor is SWOG Cancer Research Network, which has 270 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Extensive Stage Lung Small Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT04155034 reports 20 study locations spanning 5 distinct geographic areas - top geographies include California, Colorado, Alaska.
Frequently Asked Questions
What is clinical trial NCT04155034 about?
NCT04155034 is a clinical study titled "S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer". This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an...
What is the current status of trial NCT04155034?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 668 participants. The study started on 2020-05-04. Estimated completion is 2029-11-15.
What conditions does trial NCT04155034 study?
This clinical trial studies the following conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma.
What interventions are being tested in trial NCT04155034?
The interventions under investigation include: Magnetic Resonance Imaging (PROCEDURE), Prophylactic Cranial Irradiation (RADIATION).
Who is sponsoring clinical trial NCT04155034?
This trial is sponsored by SWOG Cancer Research Network, which has 270 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04155034 being conducted?
This trial has 20 study locations across Alabama, Alaska, Arizona, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Extensive Stage Lung Small Cell Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
RECRUITING · Phase 1
-
Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer
RECRUITING · Phase 1
-
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
RECRUITING · Phase 2
-
Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study
RECRUITING · Phase 2
-
Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer
RECRUITING · Phase 2
-
Phase I/II Trial in ES-SCLC to Enhance Response to Atezolizumab Plus Chemotherapy With Total Body Irradiation
RECRUITING · Phase 1
Explore more on PlainTrial
Extensive Stage Lung Small Cell Carcinoma
All registered trials for this condition
Limited Stage Lung Small Cell Carcinoma
All registered trials for this condition
Alabama
All trials with a study site in Alabama
Recruiting now
Find trials open to new participants near you
Rankings
Top sponsors, conditions, and phases
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.