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NCT04155034 · ClinicalTrials.gov registry record · Phase 3
S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
A Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma, sponsored by SWOG Cancer Research Network.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 668
- Enrollment target
- 20
- Study locations
NCT04155034: Recruiting Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma, sponsored by SWOG Cancer Research Network.
NCT04155034 is a Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma that is actively recruiting participants, run by SWOG Cancer Research Network. The registered enrollment target is 668 participants, above the 110-participant average among 16 other Extensive Stage Lung Small Cell Carcinoma trials with a reported enrollment target (507% higher). The trial reports 20 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04155034, a Phase 3 study of Extensive Stage Lung Small Cell Carcinoma and Limited Stage Lung Small Cell Carcinoma, is actively recruiting participants, sponsored by SWOG Cancer Research Network.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 668 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.
Primary Outcome
Will evaluate OS with magnetic resonance imaging (MRI) surveillance alone and MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).
Conditions Studied
Interventions
- PROCEDURE Magnetic Resonance Imaging
- RADIATION Prophylactic Cranial Irradiation
Study Locations (20)
California
- City of Hope Corona - Corona
- City of Hope Comprehensive Cancer Center - Duarte
- Veterans Affairs Loma Linda Healthcare System - Loma Linda
- Tibor Rubin VA Medical Center - Long Beach
- Los Angeles General Medical Center - Los Angeles
- USC / Norris Comprehensive Cancer Center - Los Angeles
- University of California Davis Comprehensive Cancer Center - Sacramento
- Veterans Affairs Medical Center - San Francisco - San Francisco
- City of Hope South Pasadena - South Pasadena
Colorado
- Rocky Mountain Regional VA Medical Center - Aurora
- UCHealth University of Colorado Hospital - Aurora
- UCHealth Memorial Hospital Central - Colorado Springs
- Memorial Hospital North - Colorado Springs
- Poudre Valley Hospital - Fort Collins
- Cancer Care and Hematology-Fort Collins - Fort Collins
Alaska
- Katmai Oncology Group - Anchorage
- Fairbanks Memorial Hospital - Fairbanks
Arizona
- University of Arizona Cancer Center-Orange Grove Campus - Tucson
- University of Arizona Cancer Center-North Campus - Tucson
Alabama
- University of Alabama at Birmingham Cancer Center - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 668 participants |
| Start Date | 2020-05-04 |
| Est. Completion | 2029-11-15 |
| Phase | Phase 3 |
What NCT04155034 shows while recruiting
NCT04155034 is an interventional study that assigns participants to a tested intervention. The registered 668 participants enrollment target is mid-sized for trials with a published cap, above the 110-participant average among 16 other Extensive Stage Lung Small Cell Carcinoma trials with a reported enrollment target (507% higher).
The record links to 3 conditions, with Extensive Stage Lung Small Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT04155034 names 20 study sites across 5 states, led by California, Colorado, Alaska.
Frequently Asked Questions
What is clinical trial NCT04155034 about?
NCT04155034 is a clinical study titled "S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer". This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an...
What is the current status of trial NCT04155034?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 668 participants. The study started on 2020-05-04. Estimated completion is 2029-11-15.
What conditions does trial NCT04155034 study?
This clinical trial studies the following conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma.
What interventions are being tested in trial NCT04155034?
The interventions under investigation include: Magnetic Resonance Imaging (PROCEDURE), Prophylactic Cranial Irradiation (RADIATION).
Who is sponsoring clinical trial NCT04155034?
This trial is sponsored by SWOG Cancer Research Network, which has 270 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04155034 being conducted?
This trial has 20 study locations across Alabama, Alaska, Arizona, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Extensive Stage Lung Small Cell Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04155034's enrollment target sits among peer trials
668 2nd of 16 the highest of 16 other Extensive Stage Lung Small Cell Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Extensive Stage Lung Small Cell Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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