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RECRUITING Phase 1

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

NCT06287775 · View on ClinicalTrials.gov ↗

Study Summary

This phase I/II trial tests the safety, side effects, and best dose of iadademstat when given together with atezolizumab or durvalumab, and studies the effect of the combination in treating patients with small cell lung cancer that has spread outside of the lung in which it began or to other parts of the body (extensive stage) who initially received standard of care chemotherapy and immunotherapy. Iadademstat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as atezolizumab or durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Adding iadademstat to either atezolizumab or durvalumab may be able to stabilize cancer for longer than atezolizumab or durvalumab alone in treating patients with extensive stage small cell lung cancer.

Interventions

  • PROCEDURE Biospecimen Collection
  • PROCEDURE Computed Tomography
  • BIOLOGICAL Atezolizumab
  • PROCEDURE Biopsy Procedure
  • BIOLOGICAL Durvalumab

Study Locations (20)

Connecticut

  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford
  • Yale University — New Haven
  • Yale-New Haven Hospital North Haven Medical Center — North Haven
  • Smilow Cancer Hospital Care Center at Long Ridge — Stamford
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • City of Hope at Irvine Lennar — Irvine
  • UC San Diego Moores Cancer Center — La Jolla
  • University of California Davis Comprehensive Cancer Center — Sacramento

Georgia

  • Emory University Hospital Midtown — Atlanta
  • Emory University Hospital/Winship Cancer Institute — Atlanta
  • Emory Saint Joseph's Hospital — Atlanta

Illinois

  • University of Chicago Comprehensive Cancer Center — Chicago
  • UC Comprehensive Cancer Center at Silver Cross — New Lenox
  • University of Chicago Medicine-Orland Park — Orland Park

Florida

  • UF Health Cancer Institute - Gainesville — Gainesville
  • Moffitt Cancer Center — Tampa

District of Columbia

  • MedStar Georgetown University Hospital — Washington D.C.

Indiana

  • UChicago Medicine Northwest Indiana — Crown Point

Kansas

  • University of Kansas Clinical Research Center — Fairway

Trial Details

FieldValue
Enrollment Target 45 participants
Start Date 2025-04-08
Est. Completion 2029-07-25
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06287775

The ClinicalTrials.gov registry entry for NCT06287775 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Stage IV Lung Cancer AJCC v8 appearing as the primary indexed condition, and to 5 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06287775 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Connecticut, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06287775 about?

NCT06287775 is a clinical study titled "Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer". This phase I/II trial tests the safety, side effects, and best dose of iadademstat when given together with atezolizumab or durvalumab, and studies the effect of the combination in treating patients with small cell lung cancer that has spread outside of the lung in which it began or to other parts o...

What is the current status of trial NCT06287775?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2025-04-08. Estimated completion is 2029-07-25.

What conditions does trial NCT06287775 study?

This clinical trial studies the following conditions: Stage IV Lung Cancer AJCC v8, Extensive Stage Lung Small Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06287775?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Computed Tomography (PROCEDURE), Atezolizumab (BIOLOGICAL), Biopsy Procedure (PROCEDURE), Durvalumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06287775?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06287775 being conducted?

This trial has 20 study locations across California, Connecticut, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial