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ClinicalTrials.gov 1 recruiting now official registry

Essential Hypertension clinical trials

1 of 9 indexed Essential Hypertension trials are currently recruiting.

9 US clinical trials · 1 currently recruiting

Essential Hypertension is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis, running 3 of these trials.

The research picture

Essential Hypertension has 9 registered US clinical trials, 1 of them open to new participants right now, about 11% of the total.

1
recruiting participants now
11%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
3
top sponsor: Novartis
Phase 11Phase 21Phase 33Phase 41

Active & Recent Trials

9 total, page 1 of 1

RECRUITING 2,300 participants

Childhood-Onset Essential Hypertension Natural History Study

National Human Genome Research Institute (NHGRI)

NCT06778239

ACTIVE NOT RECRUITING 1,405 participants

Effectiveness of Entresto (Sacubitril/Valsartan) in Japanese Patients With Hypertension

Novartis

NCT06604897

COMPLETED Phase 3 1,085 participants

Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension

Takeda

NCT00846365

COMPLETED Phase 3 609 participants

Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension

Takeda

NCT00818883

COMPLETED Phase 3 564 participants

A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension

Novartis

NCT00667719

COMPLETED Phase 4 328 participants

Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension.

Novartis

NCT00654875

COMPLETED Phase 1 60 participants

Hypertension: Prediction of Biofeedback Success

National Center for Complementary and Integrative Health (NCCIH)

NCT00026065

COMPLETED NA 48 participants

Bioequivalency Study of Perindopril Erbumine 8 mg Tablet Under Fasted Conditions

Roxane Laboratories

NCT01012687

COMPLETED Phase 2 30 participants

Uric Acid in Essential Hypertension in Children

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00288184

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Essential Hypertension Trial Landscape

9 indexed Essential Hypertension studies · 1 recruiting (11%).

Phase mix: 4 late (III/IV) vs 2 early (I/II).

Top sponsor: Novartis (3 trials), 5 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Essential Hypertension?

PlainTrial tracks 9 US clinical trials for Essential Hypertension, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Essential Hypertension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.