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ClinicalTrials.gov 11 recruiting now official registry

Cutaneous Squamous Cell Carcinoma clinical trials

Every US clinical trial registered for Cutaneous Squamous Cell Carcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

19 US clinical trials · 11 currently recruiting

The research picture

Cutaneous Squamous Cell Carcinoma has 19 registered US clinical trials, 11 of them open to new participants right now — about 58% of the total.

11
recruiting participants now
58%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: H. Lee Moffitt Cancer Center and Research Institute

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING Phase 1 97 participants

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Ankyra Therapeutics

NCT06171750

RECRUITING NA 94 participants

Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck

Indiana University

NCT05108090

RECRUITING 60 participants

ctDNA in Cutaneous Squamous Cell Carcinoma

Massachusetts Eye and Ear Infirmary

NCT06875609

RECRUITING Phase 1 56 participants

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05859074

RECRUITING Phase 1 48 participants

Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC)

Falo, Louis, MD

NCT05377905

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 2 24 participants

Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma

M.D. Anderson Cancer Center

NCT06567314

RECRUITING NA 20 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

AdventHealth Translational Research Institute

NCT06008977

RECRUITING Phase 2 20 participants

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

The Center for Clinical and Cosmetic Research

NCT06577311

RECRUITING Phase 2 14 participants

TIL Therapy in cSCC and MCC

Karam Khaddour, MD, MS

NCT07288073

ACTIVE NOT RECRUITING Phase 3 415 participants

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

Regeneron Pharmaceuticals

NCT03969004

ACTIVE NOT RECRUITING Phase 2 231 participants

Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer

Replimune

NCT04050436

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING Phase 1 36 participants

Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT04975152

ACTIVE NOT RECRUITING Phase 2 34 participants

A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer

Memorial Sloan Kettering Cancer Center

NCT05574101

ACTIVE NOT RECRUITING Early Phase 1 22 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05358938

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

COMPLETED Phase 2 78 participants

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

University of California, San Diego

NCT03082534

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 6
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cutaneous Squamous Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 19 US studies indexed under Cutaneous Squamous Cell Carcinoma, and 11 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cutaneous Squamous Cell Carcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cutaneous Squamous Cell Carcinoma is led by H. Lee Moffitt Cancer Center and Research Institute with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cutaneous Squamous Cell Carcinoma?

PlainTrial tracks 19 US clinical trials for Cutaneous Squamous Cell Carcinoma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cutaneous Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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