Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06106308 · ClinicalTrials.gov registry record · Phase 2
Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation
A Phase 2 study of Metastatic Colorectal Cancer and CRC, sponsored by Cardiff Oncology.
- Active
- Registry status
- Phase 2
- Development phase
- 113
- Enrollment target
- 20
- Study locations
NCT06106308 is a Phase 2 study of Metastatic Colorectal Cancer and CRC that is active but no longer recruiting, run by Cardiff Oncology. The registered enrollment target is 113 participants, below the 184-participant average among 45 other Metastatic Colorectal Cancer trials with a reported enrollment target (39% lower). The trial reports 20 study locations across 7 states.
The verdict
NCT06106308, a Phase 2 study of Metastatic Colorectal Cancer and CRC, is active but no longer recruiting, sponsored by Cardiff Oncology.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 113 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to assess 2 different doses of onvansertib to select the lowest dose that is maximally effective, and to assess the safety, efficacy, pharmacokinetics, and pharmacodynamics of onvansertib in combination with FOLFIRI + bevacizumab or FOLFOX + bevacizumab in patients with KRAS or NRAS-mutated metastatic colorectal cancer (CRC) in the first-line setting.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG FOLFIRI
- DRUG FOLFOX
- DRUG Onvansertib
Study Locations (20)
California
- Pacific Cancer Medical Center - Anaheim
- Comprehensive Blood and Cancer Center - Bakersfield - Bakersfield
- Orange Coast Memorial Medical Center - Fountain Valley
- UC San Diego Moores Cancer Center - La Jolla
- Norris Comprehensive Cancer Center - Los Angeles
- UCLA Department of Medicine-Hematology/Oncology - Los Angeles
- Sharp Memorial Hospital - San Diego
- Torrance Memorial Physician Network - Cancer Care and Infusion Center - Torrance
- PIH Health - Whittier
Florida
- Memorial Cancer Institute - Hollywood
- Mayo Clinic - Florida - Jacksonville
- Cleveland Clinic Martin Health - Stuart
Arizona
- Mayo Clinic - Arizona - Phoenix
- The University of Arizona Cancer Center - Tucson
Arkansas
- St. Bernards Medical Center - Jonesboro
- Highlands Oncology Group - Springdale
Kansas
- The University of Kansas Cancer Center - Westwood - Westwood
- Cancer Center of Kansas - Wichita
Hawaii
- Kaiser Permanente - Honolulu
Indiana
- Fort Wayne Medical Oncology and Hematology - Fort Wayne
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2024-02-27 |
| Est. Completion | 2027-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06106308
The ClinicalTrials.gov registry entry for NCT06106308 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 113 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 184-participant average among 45 other Metastatic Colorectal Cancer trials with a reported enrollment target (39% lower). The listed sponsor is Cardiff Oncology, which has 6 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Metastatic Colorectal Cancer appearing as the primary indexed condition, and to 4 interventions - of which Bevacizumab is the first listed.
NCT06106308 reports 20 study locations spanning 7 distinct geographic areas - top geographies include California, Florida, Arizona.
Frequently Asked Questions
What is clinical trial NCT06106308 about?
NCT06106308 is a clinical study titled "Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation". The purpose of this study is to assess 2 different doses of onvansertib to select the lowest dose that is maximally effective, and to assess the safety, efficacy, pharmacokinetics, and pharmacodynamics of onvansertib in combination with FOLFIRI + bevacizumab or FOLFOX + bevacizumab in patients with ...
What is the current status of trial NCT06106308?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 113 participants. The study started on 2024-02-27. Estimated completion is 2027-01.
What conditions does trial NCT06106308 study?
This clinical trial studies the following conditions: Metastatic Colorectal Cancer, CRC, KRAS/NRAS Mutation.
What interventions are being tested in trial NCT06106308?
The interventions under investigation include: Bevacizumab (DRUG), FOLFIRI (DRUG), FOLFOX (DRUG), Onvansertib (DRUG).
Who is sponsoring clinical trial NCT06106308?
This trial is sponsored by Cardiff Oncology, which has 6 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06106308 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Florida, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Colorectal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
RECRUITING · Phase 2
-
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
RECRUITING · Phase 2
-
A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
RECRUITING · Phase 2
-
Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC
RECRUITING · Phase 2
-
Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
RECRUITING · Phase 2
-
Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer
RECRUITING · Phase 2
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.