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NCT07463599 · ClinicalTrials.gov registry record · Phase 1
Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma
A Phase 1 study of Colorectal Cancer (CRC) and Metastatic Colorectal Carcinoma (mCRC), sponsored by HonorHealth Research Institute.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 126
- Enrollment target
- 1
- Study location
NCT07463599: Recruiting Phase 1 study of Colorectal Cancer (CRC) and Metastatic Colorectal Carcinoma (mCRC), sponsored by HonorHealth Research Institute.
NCT07463599 is a Phase 1 study of Colorectal Cancer (CRC) and Metastatic Colorectal Carcinoma (mCRC) that is actively recruiting participants, run by HonorHealth Research Institute. The registered enrollment target is 126 participants, below the 395-participant average among 19 other Colorectal Cancer (CRC) trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07463599, a Phase 1 study of Colorectal Cancer (CRC) and Metastatic Colorectal Carcinoma (mCRC), is actively recruiting participants, sponsored by HonorHealth Research Institute.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 126 participants
- Enrollment target
- 1
- Study location
Study Summary
This trial will evaluate the safety, tolerability, and preliminary efficacy of tegavivint as monotherapy (single) and in combination with standard therapies in patients with metastatic colorectal carcinoma (mCRC).
Primary Outcome
To establish the safety of tegavivint monotherapy treatment related toxicities as per National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 (NCI-CTC AE V5.0)
Conditions Studied
Interventions
- DRUG Tegavivint
Study Locations (1)
Arizona
- Clinical Trials Nurse Navigator - Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2026-02-17 |
| Est. Completion | 2029-07 |
| Phase | Phase 1 |
What NCT07463599 shows while recruiting
NCT07463599 is an interventional study that assigns participants to a tested intervention. The registered 126 participants enrollment target is mid-sized for trials with a published cap, below the 395-participant average among 19 other Colorectal Cancer (CRC) trials with a reported enrollment target (68% lower).
The record links to 4 conditions, with Colorectal Cancer (CRC) appearing as the primary indexed condition, and to 1 intervention - of which Tegavivint is the first listed.
NCT07463599 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT07463599 about?
NCT07463599 is a clinical study titled "Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma". This trial will evaluate the safety, tolerability, and preliminary efficacy of tegavivint as monotherapy (single) and in combination with standard therapies in patients with metastatic colorectal carcinoma (mCRC).
What is the current status of trial NCT07463599?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 126 participants. The study started on 2026-02-17. Estimated completion is 2029-07.
What conditions does trial NCT07463599 study?
This clinical trial studies the following conditions: Colorectal Cancer (CRC), Metastatic Colorectal Carcinoma (mCRC), Adenomatous Polyposis Coli (APC) Gene Mutation, Catenin Beta-1 (CTNNB1) Gene Mutation.
What interventions are being tested in trial NCT07463599?
The interventions under investigation include: Tegavivint (DRUG).
Who is sponsoring clinical trial NCT07463599?
This trial is sponsored by HonorHealth Research Institute, which has 20 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07463599 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Cancer (CRC)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07463599's enrollment target sits among peer trials
126 16th of 19 higher than 4 of 19 other Colorectal Cancer (CRC) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Cancer (CRC) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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