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ClinicalTrials.gov 10 recruiting now official registry

Colorectal Adenocarcinoma clinical trials

10 of 20 indexed Colorectal Adenocarcinoma trials are currently recruiting.

20 US clinical trials · 10 currently recruiting

Colorectal Adenocarcinoma is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 4 of these trials.

The research picture

Colorectal Adenocarcinoma has 20 registered US clinical trials, 10 of them open to new participants right now, about 50% of the total.

10
recruiting participants now
50%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: City of Hope Medical Center
Phase 18Phase 24Phase 31

Active & Recent Trials

20 total, page 1 of 1

RECRUITING 2,000 participants

Early Detection of Advanced Adenomas and Colorectal Cancer

City of Hope Medical Center

NCT06342440

RECRUITING 1,000 participants

Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study

M.D. Anderson Cancer Center

NCT04739072

RECRUITING Phase 1 474 participants

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06051695

RECRUITING 400 participants

Early Onset Colorectal Cancer Detection

City of Hope Medical Center

NCT06342401

RECRUITING 400 participants

Stage II/III Colorectal Cancer Recurrence

City of Hope Medical Center

NCT06314958

RECRUITING Phase 1 150 participants

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

Aktis Oncology

NCT07020117

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 1 53 participants

A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer

University of Chicago

NCT05200442

RECRUITING NA 20 participants

A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

Yale University

NCT07291180

RECRUITING Phase 1 10 participants

Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer

Jonsson Comprehensive Cancer Center

NCT06225011

ACTIVE NOT RECRUITING Phase 3 455 participants

Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

Alliance for Clinical Trials in Oncology

NCT04094688

ACTIVE NOT RECRUITING Phase 1 111 participants

A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors

Suzhou Transcenta Therapeutics Co.

NCT05731271

ACTIVE NOT RECRUITING Phase 1 64 participants

TAS102 in Combination With NAL-IRI in Advanced GI Cancers

Emory University

NCT03368963

ACTIVE NOT RECRUITING Phase 2 48 participants

A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

Thomas Jefferson University

NCT04111172

ACTIVE NOT RECRUITING Phase 2 48 participants

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

University of Colorado, Denver

NCT04963283

ACTIVE NOT RECRUITING Phase 2 40 participants

Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

M.D. Anderson Cancer Center

NCT03599752

ACTIVE NOT RECRUITING Phase 2 18 participants

Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer

Memorial Sloan Kettering Cancer Center

NCT04457284

COMPLETED 488 participants

Colvera for Detection of Disease Recurrence

Clinical Genomics Pathology

NCT03706235

COMPLETED 138 participants

Predicting Local and Distant Recurrence in T1 Colorectal Cancer

City of Hope Medical Center

NCT06314971

COMPLETED Phase 1 52 participants

A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer

TyrNovo

NCT04474470

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Colorectal Adenocarcinoma Trial Landscape

20 indexed Colorectal Adenocarcinoma studies · 10 recruiting (50%).

Phase mix: 1 late (III/IV) vs 12 early (I/II).

Top sponsor: City of Hope Medical Center (4 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Colorectal Adenocarcinoma?

PlainTrial tracks 20 US clinical trials for Colorectal Adenocarcinoma, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Colorectal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.