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NCT04457284 · ClinicalTrials.gov registry record · Phase 2
Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer
A Phase 2 study of Colorectal Adenocarcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 18
- Enrollment target
- 7
- Study locations
NCT04457284: Active Phase 2 study of Colorectal Adenocarcinoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT04457284 is a Phase 2 study of Colorectal Adenocarcinoma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 18 participants, below the 318-participant average among 19 other Colorectal Adenocarcinoma trials with a reported enrollment target (94% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04457284, a Phase 2 study of Colorectal Adenocarcinoma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 18 participants
- Enrollment target
- 7
- Study locations
Study Summary
This study will test whether the combination of cisplatin, nivolumab, and temozolomide is an effective treatment for in people with advanced and/or metastatic colorectal cancer that is mismatch repair-proficient (MMR-proficient). The researchers will also look at how safe the study drug combination is in participants.
Primary Outcome
will be evaluated in this study using the new international criteria proposed in RECIST 1.1 \[Eur J Ca 45:228-247, 2009\]. Changes in the largest diameter (unidimensional measurement) of the tumor and the shortest diameter of malignant lymph nodes are used with the RECIST criteria.
Conditions Studied
Interventions
- DRUG Cisplatin
- DRUG Nivolumab
- DRUG Temozolomide (TMZ)
Study Locations (7)
New York
- Memorial Sloan Kettering Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (All Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Rockville Centre
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2020-11-18 |
| Est. Completion | 2026-07 |
| Phase | Phase 2 |
What the registry record for NCT04457284 still lists
NCT04457284 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 318-participant average among 19 other Colorectal Adenocarcinoma trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Colorectal Adenocarcinoma appearing as the primary indexed condition, and to 3 interventions - of which Cisplatin is the first listed.
NCT04457284 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT04457284 about?
NCT04457284 is a clinical study titled "Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer". This study will test whether the combination of cisplatin, nivolumab, and temozolomide is an effective treatment for in people with advanced and/or metastatic colorectal cancer that is mismatch repair-proficient (MMR-proficient). The researchers will also look at how safe the study drug combination ...
What is the current status of trial NCT04457284?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 18 participants. The study started on 2020-11-18. Estimated completion is 2026-07.
What conditions does trial NCT04457284 study?
This clinical trial studies the following conditions: Colorectal Adenocarcinoma.
What interventions are being tested in trial NCT04457284?
The interventions under investigation include: Cisplatin (DRUG), Nivolumab (DRUG), Temozolomide (TMZ) (DRUG).
Who is sponsoring clinical trial NCT04457284?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04457284 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Adenocarcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04457284's enrollment target sits among peer trials
18 19th of 19 higher than 1 of 19 other Colorectal Adenocarcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Adenocarcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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