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ClinicalTrials.gov 10 recruiting now official registry

Clonal Cytopenia of Undetermined Significance clinical trials

Every US clinical trial registered for Clonal Cytopenia of Undetermined Significance — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

12 US clinical trials · 10 currently recruiting

The research picture

Clonal Cytopenia of Undetermined Significance has 12 registered US clinical trials, 10 of them open to new participants right now — about 83% of the total.

10
recruiting participants now
83%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Washington University School of Medicine

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 2,000 participants

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Mayo Clinic

NCT02958462

RECRUITING 2,000 participants

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

University of Washington

NCT06295965

RECRUITING 306 participants

CHIP/CCUS Natural History Protocol

National Heart, Lung, and Blood Institute (NHLBI)

NCT04102423

RECRUITING Phase 2 110 participants

Canakinumab for the Prevention of Progression to Cancer in Patients With Clonal Cytopenias of Unknown Significance, IMPACT Study

Uma Borate

NCT05641831

RECRUITING Early Phase 1 108 participants

Early Intervention in High Risk CCUS

Lachelle D. Weeks, MD, PhD

NCT06802146

RECRUITING Phase 2 80 participants

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

Mayo Clinic

NCT03418038

RECRUITING Phase 2 30 participants

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

University of Southern California

NCT06063486

RECRUITING Phase 2 16 participants

Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)

Washington University School of Medicine

NCT05483010

RECRUITING Phase 2 15 participants

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

M.D. Anderson Cancer Center

NCT06566742

RECRUITING Phase 2 15 participants

Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial

Washington University School of Medicine

NCT06240754

ACTIVE NOT RECRUITING 100 participants

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Massachusetts General Hospital

NCT04902833

ACTIVE NOT RECRUITING Phase 2 20 participants

Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1

Washington University School of Medicine

NCT05030441

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Clonal Cytopenia of Undetermined Significance Trial Landscape

ClinicalTrials.gov lists 12 US studies indexed under Clonal Cytopenia of Undetermined Significance, and 10 of those are currently open to recruitment — roughly 83% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Clonal Cytopenia of Undetermined Significance shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Clonal Cytopenia of Undetermined Significance is led by Washington University School of Medicine with 3 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Clonal Cytopenia of Undetermined Significance?

PlainTrial tracks 12 US clinical trials for Clonal Cytopenia of Undetermined Significance, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Clonal Cytopenia of Undetermined Significance?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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