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ClinicalTrials.gov 10 recruiting now early-phase tilt small index

Clonal Cytopenia of Undetermined Significance: early-phase trial registry

10 of 12 indexed Clonal Cytopenia of Undetermined Significance trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,429 of 28,707 conditions by registered trial count.

12 US clinical trials · 10 currently recruiting · #1,429 of 28,707 conditions by registered trial count

Clonal Cytopenia of Undetermined Significance: 12 US clinical trials tracked, 10 recruiting.

Clonal Cytopenia of Undetermined Significance is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 3 of these trials.

Enrollment posture brief

Registry condition clonal-cytopenia-of-undetermined-significance

OPEN 10 | RECR 83% | LATE 0 | EARLY 8 | RANK #1429 | SPON 3

Nearest open-share peer: Alcoholic Hepatitis (83% recruiting · 6 trials)

Clonal Cytopenia of Unde (th…83%Acute Myeloid Leukemia in Re41.7%Adenocarcinoma of the Rectum41.7%Adherence, Patient16.7%Accelerated Phase Chronic My0%
Open-enrollment share among volume-matched conditions near Clonal Cytopenia of Undetermined Significance

Clonal Cytopenia of Undetermined Significance lists 10 open slots (83% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Clonal Cytopenia of Undetermined Significance on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Clonal Cytopenia of Undetermined Significance is recruiting above its size-band peers.

    10 of 12 indexed trials (83.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Clonal Cytopenia of Undetermined Significance research.

    Washington University School of Medicine accounts for 3 of 12 trials (25%). 9 distinct sponsors appear on at least one study for this condition label.

  3. Typical Clonal Cytopenia of Undetermined Significance enrolment sits around 100 participants.

    Median target enrolment is 100 among the 12 trials that report a genuine target (sentinel values excluded). 6 of those (50%) plan for fewer than 100 participants.

  4. Clonal Cytopenia of Undetermined Significance research is mostly interventional.

    9 interventional and 3 observational studies make up this index (75% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 27

Open and recent trials

12 total, page 1 of 1

RECRUITING NA 2,000 participants

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Mayo Clinic

NCT02958462

RECRUITING 2,000 participants

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

University of Washington

NCT06295965

RECRUITING 306 participants

CHIP/CCUS Natural History Protocol

National Heart, Lung, and Blood Institute (NHLBI)

NCT04102423

RECRUITING Phase 2 110 participants

Canakinumab for the Prevention of Progression to Cancer in Patients With Clonal Cytopenias of Unknown Significance, IMPACT Study

Uma Borate

NCT05641831

RECRUITING Early Phase 1 108 participants

Early Intervention in High Risk CCUS

Lachelle D. Weeks, MD, PhD

NCT06802146

RECRUITING Phase 2 80 participants

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

Mayo Clinic

NCT03418038

RECRUITING Phase 2 30 participants

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

University of Southern California

NCT06063486

RECRUITING Phase 2 16 participants

Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)

Washington University School of Medicine

NCT05483010

RECRUITING Phase 2 15 participants

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

M.D. Anderson Cancer Center

NCT06566742

RECRUITING Phase 2 15 participants

Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial

Washington University School of Medicine

NCT06240754

ACTIVE NOT RECRUITING 100 participants

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Massachusetts General Hospital

NCT04902833

ACTIVE NOT RECRUITING Phase 2 20 participants

Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1

Washington University School of Medicine

NCT05030441

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 7

Named interventions

Most-linked intervention names on Clonal Cytopenia of Undetermined Significance records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Biospecimen Collection Procedure
3 trials
Bone Marrow Biopsy Procedure
2 trials
Piperine Extract (Standardized) Dietary supplement
1 trials
Curcumin/ Demethoxycurcumin/Bisdemethoxycurcumin-containing Supplement Dietary supplement
1 trials
Atorvastatin Drug
1 trials
Inqovi Drug
1 trials
Punch Biopsy Procedure
1 trials
Rosuvastatin Drug
1 trials

US sites by state

Facility locations filed on Clonal Cytopenia of Undetermined Significance trials. A trial with sites in several states counts in each.

Missouri 3 trials
Texas 2 trials
Ohio 2 trials
Minnesota 2 trials
Massachusetts 2 trials
Florida 2 trials
Wisconsin 1 trials
Washington 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Clonal Cytopenia of Undetermined Significance page

12 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Clonal Cytopenia of Undetermined Significance condition card totals 12 registered trials; most-linked intervention Biospecimen Collection; top US site state Missouri. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.