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ClinicalTrials.gov 4 recruiting now later-stage tilt small index

Caffeine: later-stage trial registry

4 of 7 indexed Caffeine trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #2,497 of 28,707 conditions by registered trial count.

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7 US clinical trials · 4 currently recruiting · #2,497 of 28,707 conditions by registered trial count

Caffeine: 7 US clinical trials tracked, 4 recruiting.

Caffeine is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Guayaki Sustainable Rainforest Products, running 2 of these trials.

Enrollment posture brief

Registry condition caffeine

OPEN 4 | RECR 57% | LATE 2 | EARLY 1 | RANK #2497 | SPON 2

Volume-matched condition peers

Nearest open-share peer: Adverse Childhood Experiences (57% recruiting · 14 trials)

ACL Tear71.4%ACL57.1%Caffeine (this)57%Acute Myelogenous Leukemia42.9%Acne Scars28.6%
Open-enrollment share among volume-matched conditions near Caffeine

Caffeine lists 4 open slots (57% of 7 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Caffeine on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Caffeine is recruiting above its size-band peers.

    4 of 7 indexed trials (57.1%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Caffeine research.

    Guayaki Sustainable Rainforest Products accounts for 2 of 7 trials (28.6%). 6 distinct sponsors appear on at least one study for this condition label.

  3. Most Caffeine trials plan to enrol fewer than 100 people.

    Median target enrolment is 21 among the 7 trials that report a genuine target (sentinel values excluded). 5 of those (71.4%) plan for fewer than 100 participants.

  4. Caffeine research is mostly interventional.

    7 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 42

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 4 2

Top Sponsors

Guayaki Sustainable Rainforest Products 2 trials
Hsiao-Ying Wey 1 trials
Sharp HealthCare 1 trials
University of Arizona 1 trials
University of Oklahoma 1 trials
Wake Forest University Health Sciences 1 trials

Named interventions

Most-linked intervention names on Caffeine records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Caffeine Drug
2 trials
Placebo Drug
2 trials
No theobromine Dietary supplement
1 trials
low theobromine Dietary supplement
1 trials
High theobromine Dietary supplement
1 trials
Low caffeine Dietary supplement
1 trials
High Caffeine Dietary supplement
1 trials
Test caffeinated beverage Other
1 trials

US sites by state

Facility locations filed on Caffeine trials. A trial with sites in several states counts in each.

California 3 trials
Oklahoma 1 trials
North Carolina 1 trials
Massachusetts 1 trials
Arizona 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Related

Read our methodology - how this data is sourced, computed, and verified.

What to do with this Caffeine page

7 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Caffeine condition card totals 7 registered trials; most-linked intervention Caffeine; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.