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ClinicalTrials.gov 8 recruiting now official registry

Adverse Childhood Experiences clinical trials

8 of 14 indexed Adverse Childhood Experiences trials are currently recruiting.

14 US clinical trials · 8 currently recruiting

Adverse Childhood Experiences is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Nathaniel Jenkins, running 2 of these trials.

The research picture

Adverse Childhood Experiences has 14 registered US clinical trials, 8 of them open to new participants right now, about 57% of the total.

8
recruiting participants now
57%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Nathaniel Jenkins
Phase 11

Active & Recent Trials

14 total, page 1 of 1

RECRUITING 2,500 participants

School Violence Exposure as an Adverse Childhood Experience

Teachers College, Columbia University

NCT06153316

RECRUITING NA 360 participants

Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program

RTI International

NCT06236100

RECRUITING NA 340 participants

Building Resilient Families

Loma Linda University

NCT05388864

RECRUITING NA 210 participants

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

University of California, Irvine

NCT06821035

RECRUITING Early Phase 1 150 participants

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

Duke University

NCT05665465

RECRUITING NA 70 participants

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

Nathaniel Jenkins

NCT06454344

RECRUITING NA 30 participants

ACEs, SIRT1, and Premature Vascular Aging in Humans

Nathaniel Jenkins

NCT07073352

RECRUITING NA 20 participants

Early Life Exposures Among Children With Sickle Cell Disease

University of Alabama at Birmingham

NCT05377372

ACTIVE NOT RECRUITING NA 75 participants

Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition

Nova Southeastern University

NCT06269614

ACTIVE NOT RECRUITING NA 12 participants

Playing Playfully to Overcome Adversity

Sacred Heart University

NCT06985017

COMPLETED NA 318 participants

The Impact of an Adapted Version of the Strengthening Families Program on IPV Among Caregivers and ACEs Among Children

University of Nebraska Lincoln

NCT05129501

COMPLETED 120 participants

ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life

The Cooper Health System

NCT05731557

COMPLETED NA 50 participants

Brief Intervention for Chronic Pain and History of Stressful Experiences

Brigham and Women's Hospital

NCT06983327

COMPLETED 42 participants

Journey of Hope in Appalachia: Supporting Resilience in the Region's Youth

Gia Mudd

NCT04096937

Phase Distribution

PhaseTrial count
Phase 1 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Adverse Childhood Experiences Trial Landscape

14 indexed Adverse Childhood Experiences studies · 8 recruiting (57%).

Phase mix: 0 late (III/IV) vs 1 early (I/II).

Top sponsor: Nathaniel Jenkins (2 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Adverse Childhood Experiences?

PlainTrial tracks 14 US clinical trials for Adverse Childhood Experiences, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Adverse Childhood Experiences?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.