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Adverse Childhood Experiences
Open-data reference.
14 US clinical trials · 8 currently recruiting
Active & Recent Trials
School Violence Exposure as an Adverse Childhood Experience
Teachers College, Columbia University
NCT06153316
Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
RTI International
NCT06236100
Building Resilient Families
Loma Linda University
NCT05388864
The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments
University of California, Irvine
NCT06821035
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Duke University
NCT05665465
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Nathaniel Jenkins
NCT06454344
ACEs, SIRT1, and Premature Vascular Aging in Humans
Nathaniel Jenkins
NCT07073352
Early Life Exposures Among Children With Sickle Cell Disease
University of Alabama at Birmingham
NCT05377372
Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition
Nova Southeastern University
NCT06269614
Playing Playfully to Overcome Adversity
Sacred Heart University
NCT06985017
The Impact of an Adapted Version of the Strengthening Families Program on IPV Among Caregivers and ACEs Among Children
University of Nebraska Lincoln
NCT05129501
ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life
The Cooper Health System
NCT05731557
Brief Intervention for Chronic Pain and History of Stressful Experiences
Brigham and Women's Hospital
NCT06983327
Journey of Hope in Appalachia: Supporting Resilience in the Region's Youth
Gia Mudd
NCT04096937
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Adverse Childhood Experiences Trial Landscape
ClinicalTrials.gov lists 14 US studies indexed under Adverse Childhood Experiences, and 8 of those are currently open to recruitment — roughly 57% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Adverse Childhood Experiences shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Adverse Childhood Experiences is led by Nathaniel Jenkins with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 14 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Adverse Childhood Experiences?
PlainTrial tracks 14 US clinical trials for Adverse Childhood Experiences, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Adverse Childhood Experiences?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.