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COMPLETED NA

Effects of a Cocoa Shot on the Human Brain

NCT01924481 · View on ClinicalTrials.gov ↗

Study Summary

The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function. The main substances in the drinks that are known to influence the brain are caffeine (and related chemicals such as theobromine) and flavonoids. Flavonoids are chemical found in plants and are most commonly associated with antioxidant activity. Caffeine, chemicals related to caffeine, and flavonoids are all naturally occurring and all potentially alter brain physiology. This study will evaluate changes in brain blood flow and cognition following the consumption of drinks with various combinations of the Primary Ingredients. Caffeine is likely to have peak effects within 1-hour of ingesting the chocolate while the flavonoids are likely to have peak effects 3-4 hours after ingestion. The study proposed here will evaluate ingredients in a 4-arm cross-over double-blind design in an attempt to understand the differential effects of these compounds in chocolate drinks.

Conditions Studied

Interventions

  • DIETARY_SUPPLEMENT High Caffeine
  • DIETARY_SUPPLEMENT Low caffeine
  • DIETARY_SUPPLEMENT High theobromine
  • DIETARY_SUPPLEMENT low theobromine
  • DIETARY_SUPPLEMENT No theobromine

Study Locations (1)

North Carolina

  • Wake Forest University Health Sciences — Winston-Salem

Trial Details

FieldValue
Enrollment Target 6 participants
Start Date 2013-09
Est. Completion 2013-10
Phase NA

Sponsor

Wake Forest University Health Sciences

1,061 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01924481

The ClinicalTrials.gov registry entry for NCT01924481 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 6 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Wake Forest University Health Sciences, which has 1,061 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Caffeine appearing as the primary indexed condition, and to 5 interventions — of which High Caffeine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01924481 reports 1 study location spanning 1 distinct geographic area — top geographies include North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01924481 about?

NCT01924481 is a clinical study titled "Effects of a Cocoa Shot on the Human Brain". The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function. The main substances in the drinks that are known to influence the brain are caffeine (and related chemicals such as theobromine) and flavonoids. Flavonoids are ch...

What is the current status of trial NCT01924481?

This trial is currently completed. It is a NA study. The enrollment target is 6 participants. The study started on 2013-09. Estimated completion is 2013-10.

What conditions does trial NCT01924481 study?

This clinical trial studies the following conditions: Caffeine, Flavonoids. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01924481?

The interventions under investigation include: High Caffeine (DIETARY_SUPPLEMENT), Low caffeine (DIETARY_SUPPLEMENT), High theobromine (DIETARY_SUPPLEMENT), low theobromine (DIETARY_SUPPLEMENT), No theobromine (DIETARY_SUPPLEMENT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01924481?

This trial is sponsored by Wake Forest University Health Sciences, which has 1,061 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01924481 being conducted?

This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial