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ClinicalTrials.gov 2 recruiting now official registry

B-cell Chronic Lymphocytic Leukemia clinical trials

2 of 8 indexed B-cell Chronic Lymphocytic Leukemia trials are currently recruiting.

8 US clinical trials · 2 currently recruiting

B-cell Chronic Lymphocytic Leukemia is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

B-cell Chronic Lymphocytic Leukemia has 8 registered US clinical trials, 2 of them open to new participants right now, about 25% of the total.

2
recruiting participants now
25%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 15Phase 22Phase 31

Active & Recent Trials

8 total, page 1 of 1

RECRUITING Phase 3 386 participants

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

Grifols Therapeutics

NCT05645107

RECRUITING Phase 1 132 participants

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

National Cancer Institute (NCI)

NCT06364423

ACTIVE NOT RECRUITING Phase 1 58 participants

Trial of Anti-CD19 and Anti-CD20 Bicistronic Chimeric Antigen Receptor T Cells for Treating B-Cell Malignancies

National Cancer Institute (NCI)

NCT05797233

COMPLETED Phase 2 63 participants

Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma

Fred Hutchinson Cancer Center

NCT00867529

COMPLETED Phase 2 60 participants

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

National Cancer Institute (NCI)

NCT01258998

COMPLETED Phase 1 52 participants

ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies

AbbVie (prior sponsor, Abbott)

NCT01110473

COMPLETED Phase 1 22 participants

Imprime PGG, Alemtuzumab, and Rituximab in Treating Patients With High Risk Chronic Lymphocytic Leukemia

Mayo Clinic

NCT01269385

COMPLETED Phase 1 21 participants

Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL)

Ohio State University Comprehensive Cancer Center

NCT01212380

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the B-cell Chronic Lymphocytic Leukemia Trial Landscape

8 indexed B-cell Chronic Lymphocytic Leukemia studies · 2 recruiting (25%).

Phase mix: 1 late (III/IV) vs 7 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 5 others listed. 8 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for B-cell Chronic Lymphocytic Leukemia?

PlainTrial tracks 8 US clinical trials for B-cell Chronic Lymphocytic Leukemia, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for B-cell Chronic Lymphocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.