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ClinicalTrials.gov 2 recruiting now early-phase tilt small index

B-cell Chronic Lymphocytic Leukemia: early-phase trial registry

2 of 8 indexed B-cell Chronic Lymphocytic Leukemia trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #2,176 of 28,707 conditions by registered trial count.

8 US clinical trials · 2 currently recruiting · #2,176 of 28,707 conditions by registered trial count

B-cell Chronic Lymphocytic Leukemia: 8 US clinical trials tracked, 2 recruiting.

B-cell Chronic Lymphocytic Leukemia is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

Enrollment posture brief

Registry condition b-cell-chronic-lymphocytic-leukemia

OPEN 2 | RECR 25% | LATE 1 | EARLY 7 | RANK #2176 | SPON 3

Nearest open-share peer: Abdominal Pain (25% recruiting · 20 trials)

Activity, Motor75%Achalasia50%Abdominal Cancer25%Acne Scars - Mixed Atrophic 25%B-cell Chronic Lymphocyt (th…25%
Open-enrollment share among volume-matched conditions near B-cell Chronic Lymphocytic Leukemia

B-cell Chronic Lymphocytic Leukemia lists 2 open slots (25% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for B-cell Chronic Lymphocytic Leukemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. B-cell Chronic Lymphocytic Leukemia is recruiting below its size-band peers.

    2 of 8 indexed trials (25%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates B-cell Chronic Lymphocytic Leukemia research.

    National Cancer Institute (NCI) accounts for 3 of 8 trials (37.5%). 6 distinct sponsors appear on at least one study for this condition label.

  3. Most B-cell Chronic Lymphocytic Leukemia trials plan to enrol fewer than 100 people.

    Median target enrolment is 60 among the 8 trials that report a genuine target (sentinel values excluded). 6 of those (75%) plan for fewer than 100 participants.

  4. B-cell Chronic Lymphocytic Leukemia research is mostly interventional.

    8 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 22Phase 31

Open and recent trials

8 total, page 1 of 1

RECRUITING Phase 3 386 participants

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

Grifols Therapeutics

NCT05645107

RECRUITING Phase 1 132 participants

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

National Cancer Institute (NCI)

NCT06364423

ACTIVE NOT RECRUITING Phase 1 58 participants

Trial of Anti-CD19 and Anti-CD20 Bicistronic Chimeric Antigen Receptor T Cells for Treating B-Cell Malignancies

National Cancer Institute (NCI)

NCT05797233

COMPLETED Phase 2 63 participants

Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma

Fred Hutchinson Cancer Center

NCT00867529

COMPLETED Phase 2 60 participants

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

National Cancer Institute (NCI)

NCT01258998

COMPLETED Phase 1 52 participants

ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies

AbbVie (prior sponsor, Abbott)

NCT01110473

COMPLETED Phase 1 22 participants

Imprime PGG, Alemtuzumab, and Rituximab in Treating Patients With High Risk Chronic Lymphocytic Leukemia

Mayo Clinic

NCT01269385

COMPLETED Phase 1 21 participants

Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL)

Ohio State University Comprehensive Cancer Center

NCT01212380

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 2
Phase 3 1

Named interventions

Most-linked intervention names on B-cell Chronic Lymphocytic Leukemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

laboratory biomarker analysis Other
3 trials
rituximab Biological
2 trials
Fludarabine Drug
2 trials
Cyclophosphamide Drug
2 trials
ABT-348 and azacitidine Drug
1 trials
ABT-348 Drug
1 trials
PGG beta-glucan Drug
1 trials
Pharmacogenomic Studies Other
1 trials

US sites by state

Facility locations filed on B-cell Chronic Lymphocytic Leukemia trials. A trial with sites in several states counts in each.

Maryland 3 trials
Texas 2 trials
Ohio 2 trials
Washington 1 trials
South Carolina 1 trials
North Carolina 1 trials
Minnesota 1 trials
Georgia 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this B-cell Chronic Lymphocytic Leukemia page

8 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This B-cell Chronic Lymphocytic Leukemia condition card totals 8 registered trials; most-linked intervention laboratory biomarker analysis; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.