Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Aortic Valve Insufficiency clinical trials
Every US clinical trial registered for Aortic Valve Insufficiency — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
12 US clinical trials · 4 currently recruiting
The research picture
Aortic Valve Insufficiency has 12 registered US clinical trials, 4 of them open to new participants right now — about 33% of the total.
- 4
- recruiting participants now
- 33%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 3
- top sponsor: JenaValve Technology
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Transpacific TAVR Registry
Duk-Woo Park, MD
NCT03826264
ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™
JenaValve Technology
NCT06608823
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Edwards Lifesciences
NCT05172973
The JenaValve ALIGN-AR LVAD Registry
JenaValve Technology
NCT06594705
Identification of Genetic Causes of Calcific Aortic Valve Disease
Beth Israel Deaconess Medical Center
NCT04149600
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Emblok
NCT05295628
The JenaValve ALIGN-AR Pivotal Trial
JenaValve Technology
NCT04415047
J-Valve TF Early Feasibility Study
JC Medical, Inc., an affiliate of Edwards Lifesciences
NCT06034028
Aortic Valve Replacement With Trifecta(TM)
Abbott Medical Devices
NCT00475709
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
Avant Immunotherapeutics
NCT00082121
Investigation of Heart Function in Patients With Heart Valve Defects
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001314
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Aortic Valve Insufficiency Trial Landscape
ClinicalTrials.gov lists 12 US studies indexed under Aortic Valve Insufficiency, and 4 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Aortic Valve Insufficiency shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Aortic Valve Insufficiency is led by JenaValve Technology with 3 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Aortic Valve Insufficiency?
PlainTrial tracks 12 US clinical trials for Aortic Valve Insufficiency, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Aortic Valve Insufficiency?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.