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Aortic Valve Insufficiency: early-phase trial registry
4 of 12 indexed Aortic Valve Insufficiency trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,429 of 28,707 conditions by registered trial count.
12 US clinical trials · 4 currently recruiting · #1,429 of 28,707 conditions by registered trial count
Aortic Valve Insufficiency: 12 US clinical trials tracked, 4 recruiting.
Aortic Valve Insufficiency is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is JenaValve Technology, running 3 of these trials.
Enrollment posture brief
Registry condition aortic-valve-insufficiency
OPEN 4 | RECR 33% | LATE 0 | EARLY 1 | RANK #1429 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)
Aortic Valve Insufficiency lists 4 open slots (33% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Aortic Valve Insufficiency on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Aortic Valve Insufficiency is recruiting below its size-band peers.
4 of 12 indexed trials (33.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Aortic Valve Insufficiency research.
JenaValve Technology accounts for 3 of 12 trials (25%). 9 distinct sponsors appear on at least one study for this condition label.
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Typical Aortic Valve Insufficiency enrolment sits around 532 participants.
Median target enrolment is 532 among the 12 trials that report a genuine target (sentinel values excluded). 2 of those (16.7%) plan for fewer than 100 participants.
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Aortic Valve Insufficiency research is mostly interventional.
9 interventional and 3 observational studies make up this index (75% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
12 total, page 1 of 1
Transpacific TAVR Registry
Duk-Woo Park, MD
NCT03826264
ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™
JenaValve Technology
NCT06608823
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Edwards Lifesciences
NCT05172973
The JenaValve ALIGN-AR LVAD Registry
JenaValve Technology
NCT06594705
Identification of Genetic Causes of Calcific Aortic Valve Disease
Beth Israel Deaconess Medical Center
NCT04149600
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Emblok
NCT05295628
The JenaValve ALIGN-AR Pivotal Trial
JenaValve Technology
NCT04415047
J-Valve TF Early Feasibility Study
JC Medical, Inc., an affiliate of Edwards Lifesciences
NCT06034028
Aortic Valve Replacement With Trifecta(TM)
Abbott Medical Devices
NCT00475709
Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery
Avant Immunotherapeutics
NCT00082121
Investigation of Heart Function in Patients With Heart Valve Defects
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001314
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Aortic Valve Insufficiency records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Aortic Valve Insufficiency trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Aortic Valve Insufficiency page
12 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Aortic Valve Insufficiency trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- JenaValve Technology sponsors the most Aortic Valve Insufficiency trials on record, review their full trial history before evaluating a specific study. See JenaValve Technology's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Aortic Valve Insufficiency condition card totals 12 registered trials; most-linked intervention JenaValve Trilogy Heart Valve System; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.